This chapter explores the archaeology of late antique Syria, emphasising its historical significance and research challenges. Syria has one of the highest concentrations of late antique sites, particularly in the Limestone Massif, yet modern national borders obscure historical connections with Lebanon, Jordan and Turkey. Drawing on historical texts, travel accounts and archaeological surveys, the chapter traces the development of research from early European explorers to twentieth-century French-led excavations. It examines the influence of colonial mandates and political changes, including the impact of the Syrian civil war on archaeological preservation. A central argument is that late antique Syria has been overlooked in favour of earlier Roman and later Islamic studies. Limited excavations, instability and destruction have further hindered research. However, the chapter stresses the importance of studying Syria’s role in connecting the Roman, Persian and early Islamic worlds. Instead of focusing solely on elite monuments, the chapter calls for research on everyday settlements to provide a fuller picture of Syrian society during Late Antiquity.