Book contents
- Cognitive Changes and the Aging Brain
- Cognitive Changes and the Aging Brain
- Copyright page
- Dedication
- Contents
- Contributors
- Chapter 1 Introduction
- Chapter 2 Anatomic and Histological Changes of the Aging Brain
- Chapter 3 Cellular and Molecular Mechanisms for Age-Related Cognitive Decline
- Chapter 4 Neuroimaging of the Aging Brain
- Chapter 5 Changes in Visuospatial, Visuoperceptual, and Navigational Ability in Aging
- Chapter 6 Chemosensory Function during Neurologically Healthy Aging
- Chapter 7 Memory Changes in the Aging Brain
- Chapter 8 Aging-Related Alterations in Language
- Chapter 9 Changes in Emotions and Mood with Aging
- Chapter 10 Aging and Attention
- Chapter 11 Changes in Motor Programming with Aging
- Chapter 12 Alterations in Executive Functions with Aging
- Chapter 13 Brain Aging and Creativity
- Chapter 14 Attractor Network Dynamics, Transmitters, and Memory and Cognitive Changes in Aging
- Chapter 15 Mechanisms of Aging-Related Cognitive Decline
- Chapter 16 The Influence of Physical Exercise on Cognitive Aging
- Chapter 17 Pharmacological Cosmetic Neurology
- Chapter 18 Cognitive Rehabilitation in Healthy Aging
- Chapter 19 Preventing Cognitive Decline and Dementia
- Index
- References
Chapter 2 - Anatomic and Histological Changes of the Aging Brain
Published online by Cambridge University Press: 30 November 2019
- Cognitive Changes and the Aging Brain
- Cognitive Changes and the Aging Brain
- Copyright page
- Dedication
- Contents
- Contributors
- Chapter 1 Introduction
- Chapter 2 Anatomic and Histological Changes of the Aging Brain
- Chapter 3 Cellular and Molecular Mechanisms for Age-Related Cognitive Decline
- Chapter 4 Neuroimaging of the Aging Brain
- Chapter 5 Changes in Visuospatial, Visuoperceptual, and Navigational Ability in Aging
- Chapter 6 Chemosensory Function during Neurologically Healthy Aging
- Chapter 7 Memory Changes in the Aging Brain
- Chapter 8 Aging-Related Alterations in Language
- Chapter 9 Changes in Emotions and Mood with Aging
- Chapter 10 Aging and Attention
- Chapter 11 Changes in Motor Programming with Aging
- Chapter 12 Alterations in Executive Functions with Aging
- Chapter 13 Brain Aging and Creativity
- Chapter 14 Attractor Network Dynamics, Transmitters, and Memory and Cognitive Changes in Aging
- Chapter 15 Mechanisms of Aging-Related Cognitive Decline
- Chapter 16 The Influence of Physical Exercise on Cognitive Aging
- Chapter 17 Pharmacological Cosmetic Neurology
- Chapter 18 Cognitive Rehabilitation in Healthy Aging
- Chapter 19 Preventing Cognitive Decline and Dementia
- Index
- References
Summary
This chapter discusses the age-related microscopic changes affecting neurons and glia emphasizing the alterations seen in cognitively intact individuals, although some changes also occur in neurodegenerative diseases. Also reviewed are common histopathological correlates of white matter changes and small vessel cerebrovascular changes. One age-associated vascular lesion, brain arteriolosclerosis, was recently shown to be related to “hippocampal sclerosis of aging.” The two disease entities are now collectively called “cerebral age-related TDP43 and sclerosis.” Finally, amyloid accumulation without tau or other neuropathologies, termed “pathological aging,” is discussed with a review of current described conditions occurring during aging, e.g., “primary age-related tauopathy” and “aging-related tau astrogliopathy.”
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- Cognitive Changes and the Aging Brain , pp. 5 - 15Publisher: Cambridge University PressPrint publication year: 2019