Skip to main content Accessibility help
Hostname: page-component-8448b6f56d-mp689 Total loading time: 0 Render date: 2024-04-19T21:26:31.368Z Has data issue: false hasContentIssue false

16 - Measuring the mind: detecting cognitive deficits and measuring cognitive change in patients with depression

from Part III - Evaluating cognitive dysfunction in major depressive disorder

Published online by Cambridge University Press:  05 March 2016

Roger S. McIntyre
University of Toronto
Danielle S. Cha
University of Toronto
Get access
Cognitive Impairment in Major Depressive Disorder
Clinical Relevance, Biological Substrates, and Treatment Opportunities
, pp. 229 - 241
Publisher: Cambridge University Press
Print publication year: 2016

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)


Conradi, H. J., Ormel, J., & de Jonge, P. (2011). Presence of individual (residual) symptoms during depressive episodes and periods of remission: A 3-year prospective study. Psychological Medicine, 41(6): 11651174.CrossRefGoogle ScholarPubMed
Ferris, S. H., Lucca, U., Mohs, R., Dubois, B., Wesnes, K., Erzigkeit, H., … Bodick, N. (1997). Objective psychometric tests in clinical trials of dementia drugs: Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. Alzheimer Disease and Associated Disorders, 11(Suppl. 3): 3438.Google Scholar
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12: 189198.CrossRefGoogle ScholarPubMed
Grober, E. and Sliwinski, M. (1991). Development and validation of a model for estimating premorbid verbal intelligence in the elderly. Journal of Clinical and Experimental Neuropsychology, 13(6): 933949.CrossRefGoogle Scholar
Harrison, J., Buxton, P., Husain, M., & Wise, R. (2000). Short test of semantic and phonological fluency: Normal performance, validity and test-retest reliability. British Journal of Clinical Psychology, 39(2): 181191.Google Scholar
Harrison, J., Lophaven, S., & Olsen, C. K. (2014). Which cognitive domains are improved by treatment with vortioxetine? Poster NR6-105 at the American Psychiatric Association Meeting, New York.Google Scholar
Harrison, J. and Maruff, P. (2008). Measuring the mind: Assessing cognitive change in clinical drug trials. Expert Reviews in Clinical Pharmacology, 1(4): 471473.Google Scholar
Harrison, J., Minassian, S. L., Jenkins, L., Black, R. S., Koller, M., & Grundman, M. (2007). A neuropsychological test battery for use in Alzheimer disease clinical trials. Archives of Neurology, 64(9): 13231329.Google Scholar
Henderson, L., Harrison, J., & Kennard, C. (2001). Selectively impaired reaction time in Parkinson’s disease: Persistent absence of simple reaction advantage in a patient with frontal complications. Neurocase, 7(4): 319330.Google Scholar
Hilt, D., Gawryl, M., & Koenig, G. (2009). ECP-6124: Safety, tolerability and cognitive effects of a novel A7 nicotinic receptor agonist in Alzheimer’s disease patients on stable donepezil or rivastigmine therapy. Alzheimer’s & Dementia: Journal of the Alzheimer’s Association, 5(4): e32. doi: Scholar
Hufford, M. R., Davis, V. G., Hilt, D., Dgetluck, N., Geffen, Y., Loebel, A., … Keefe, R. S. E. (2014). Circadian rhythms in cognitive functioning among patients with schizophrenia: Impact on signal detection in clinical trials of pro-cognitive therapies. Schizophrenia Research. doi: Scholar
Katona, C., Hansen, T., & Olsen, C. K. (2012). A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder. International Clinical Psychopharmacology, 27(4): 215223.Google Scholar
Lam, R. W., Saragoussi, D., Danchenko, N., Rive, B., Lamy, F. X., & Brevig, T. (2013). Psychometric Validation of Perceived Deficits Questionnaire – Depression (PDQ–D) in patients with major depressive disorder (MDD). Value in Health, 16(7): A330.CrossRefGoogle Scholar
Lee, R. S. C., Hermens, D. F., Porter, M. A., & Redoblado-Hodge, M. A. (2012). A meta-analysis of cognitive deficits in first-episode major depressive disorder. Journal of Affective Disorders, 140(2): 113124.Google Scholar
Lezak, M. D. (1995). Neuropsychological Assessment. Oxford University Press.Google Scholar
Lovera, J., Bagert, B., Smoot, K. H., Wild, K., Frank, R., Bogardus, K., … Bourdette, D. N. (2006). Correlations of Perceived Deficits Questionnaire of Multiple Sclerosis Quality of Life Inventory with Beck Depression Inventory and neuropsychological tests. Journal of Rehabilitation Research and Development, 43(1): 7382.CrossRefGoogle ScholarPubMed
McIntyre, R. S., Lophaven, S., & Olsen, C. K. (2014). A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults. International Journal of Neuropsychopharmacology, 17(10): 15571567.Google Scholar
Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., … Chertkow, H. (2005). The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society, 53(4): 695699.CrossRefGoogle Scholar
Nelson, H. E. (1982). The National Adult Reading Test (NART): Test Manual. Windsor: NFER-Nelson.Google Scholar
Nuechterlein, K. H., Green, M. F., Kern, R. S., Baade, L. E., Barch, D. M., Cohen, J. D., … Marder, S. R. (2008). The MATRICS Consensus Cognitive Battery, part 1: Test selection, reliability, and validity. American Journal of Psychiatry, 165(2): 203213.Google Scholar
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999). Mild cognitive impairment: Clinical characterization and outcome. Archives of Neurology, 56(3): 303308.Google Scholar
Rock, P. L., Roiser, J. P., Riedel, W. J., & Blackwell, A. D. (2014). Cognitive impairment in depression: A systematic review and meta-analysis. Psychological Medicine, 44: 20292040.CrossRefGoogle ScholarPubMed
Rosen, W. G., Mohs, R. C., & Davis, K. L. (1984). A new rating scale for Alzheimer’s disease. American Journal of Psychiatry, 141(11): 13561364.Google Scholar
Taylor, B. N. & Kuyatt, C. E. (1994). NIST Technical Note 1297 Guidelines for Evaluating and Expressing the Uncertainty of NIST Measurement Results. Physics Laboratory National Institute of Standards and Technology, Gaithersburg, MD 208990001.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the or variations. ‘’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats