Although a number of funders are now actively encouraging collaboration between artists and researchers, this is not a new field. Artists have appropriated technological developments for hundreds of years (if not longer), and there are challenging examples today of Bio-Art, where artists use tools, such as genetic engineering to create living artworks. What is new is the ways that researchers are now becoming involved as co-creators in artistic projects. With this in mind, the chapter explores audiences for the arts, before moving on to discuss examples of the ways that artists and researchers might work together. We consider issues around collaborative working, before briefly discussing the potential impact of artistic approaches to public engagement.