This chapter discusses the connection between philosophy and ignorance. It examines some of the lessons on ignorance taught by Socrates, and suggests that, while literature and philosophy can be combined and differentiated in a number of ways, the main distinction made with regards to ignorance is on the question of whether or not one moves beyond not knowing. The chapter then studies the ‘disease’ of ignorance, which may be said to make up the very condition of poetry and of literature, and also considers the possibility to see philosophical scepticism as part of, or engaged with, a theory of ignorance.