Written during a crisis, this volume betrays an awareness that the field of ‘literature and medicine’ is at a crossroads. It anticipates the many directions that researchers can take, but also records the anxieties involved in not knowing what lies ahead. We take three steps in this Afterword, which may pave the way for future forays into this area. First, we sketch how the particular ‘medical’ event of the pandemic has transformed literature as medium, art form, and practice. By identifying the thematic and formal trends, we also signal the necessary methodological adjustments that we will have to take to assess these critically. Second, with a view to these changes and the necessary opening up of the field of medicine and literature that the pandemic has made visible, we draw attention to the thematic and formal trends that may be helpful in this endeavour. With a view to the volume chapters, we identify the possible directions that can be intensified in the future. Finally, under the heading ‘Medicine and Literature, quo vadis’, we indicate some of the ways in which, we strongly believe, scholars across Medical and Health Humanities, literature and medicine, and humanities in general, might be going.