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Chapter 13 - Fertility and the Hypogonadal Male

Published online by Cambridge University Press:  03 June 2019

By
Andrew A. Dwyer  and
Richard Quinton
Edited by
Jane A. Stewart
Jane A. Stewart
Affiliation:
Newcastle Hospitals NHS Foundation Trust
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Summary

The appearance of Leydig cells within the testes of a 46XY fetus from 7–10 weeks gestation marks the onset of testosterone (T) secretion stimulated by placental gonadotrophin (hCG). T diverts development from female default towards external male phenotype. The testes then begin their hormonally induced descent, while Sertoli cell–derived anti-mullerian hormone (AMH) induces regression of internal female reproductive organs.

Type
Chapter
Information
Subfertility, Reproductive Endocrinology and Assisted Reproduction , pp. 94 - 105
Publisher: Cambridge University Press
Print publication year: 2019

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References

Background Reading

Hamda, A & Bouloux, P-MG. 2013 Primary hypogonadism. In Oxford Endocrinology Library: Testosterone Deficiency in Men, Jones, TH, Ed. Oxford University Press [ISBN 978-0-19-965167-2]; chapter 5: pp 35–44.Google Scholar
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Dwyer, AA, Raivio, T & Pitteloud, N. Gonadotrophin replacement for induction of fertility in hypogonadal men. Best Practice & Research: Clinical Endocrinology & Metabolism. 2015; 29: 91–103.Google Scholar

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