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  3. Boolean Networks as Predictive Models of Emergent Biological Behaviors
  • Cited by 2
Publisher:
Cambridge University Press
Online publication date:
March 2024
Print publication year:
2024
Online ISBN:
9781009292955
DOI:
https://doi.org/10.1017/9781009292955
Subjects:
Physics and Astronomy, Statistical Physics
Series:
Elements in the Structure and Dynamics of Complex Networks
Information

Book description

Interacting biological systems at all organizational levels display emergent behavior. Modeling these systems is made challenging by the number and variety of biological components and interactions – from molecules in gene regulatory networks to species in ecological networks – and the often-incomplete state of system knowledge, such as the unknown values of kinetic parameters for biochemical reactions. Boolean networks have emerged as a powerful tool for modeling these systems. This Element provides a methodological overview of Boolean network models of biological systems. After a brief introduction, the authors describe the process of building, analyzing, and validating a Boolean model. They then present the use of the model to make predictions about the system's response to perturbations and about how to control its behavior. The Element emphasizes the interplay between structural and dynamical properties of Boolean networks and illustrates them in three case studies from disparate levels of biological organization.

References

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