Cancer Symptom Science: Measurement, Mechanisms, and Management

doi:10.1017/CBO9780511780868

Cancer Symptom Science is the first interdisciplinary compilation of research on the mechanisms underlying the expression of cancer-related symptoms. It presents innovations in clinical, animal and in vitro research, research methods in brain imaging, and statistical-descriptive approaches to understanding the mechanistic basis of symptom expression. This volume also provides perspectives from patients, government and industry. By collecting and synthesizing the developing threads of new approaches to understanding cancer-related symptoms, the book promotes a pioneering framework for merging behavioral and biological disciplines to clarify mechanisms of symptom evolution, incorporating new technologies, testing novel agents for symptom control, and improving patient functioning and quality of life both during and after cancer treatment. With an expert editorial team led by Charles S. Cleeland, an internationally-recognized leader in cancer pain assessment and treatment, this is essential reading for surgical, clinical and medical oncologists, academic researchers, and pharmaceutical companies developing new agents to control symptom expression.

"This text is of great importance to readers of the Journal of Pain and Symptom Management ...The content is quite timely, and these exceptional editors, who are recognized leaders in the field of cancer symptom research, are to be congratulated for meeting their aims of promoting an interdisciplinary approach to investigating these complex symptoms. The writing and organization are clear, and the information is easily accessible to the reader, with a thorough table of contents and index. This is an essential text for anyone interested in conducting or critiquing cancer symptom research."Journal of Pain and Symptom Management (2011), Judith Paice, PhD, RN, Northwestern University

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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Contributors
pp vii-x
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Foreword
pp xi-xvi
- By Ellen Stovall
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Credits and acknowledgements
pp xvii-xviii
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Section 1 - Introduction
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1 - Introduction to cancer symptom science
pp 1-3
- By Charles S. Cleeland, The University of Texas M. D. Anderson Cancer Center, Michael J. Fisch, The University of Texas M. D. Anderson Cancer Center, Adrian J. Dunn, University of Hawaii at Manoa
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2 - Researching the mechanisms underlying the symptoms of patients with cancer
pp 4-7
- By Adrian J. Dunn, University of Hawaii at Manoa
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3 - Cytokines and sickness behavior: a model for cancer symptoms
pp 8-17
- By Steven S. Zalcman, University of Medicine & Dentistry of New Jersey – New Jersey Medical School, Randall T. Woodruff, University of Medicine & Dentistry of New Jersey – New Jersey Medical School, Ruchika Mohla, University of Medicine & Dentistry of New Jersey – New Jersey Medical School, Allan Siegel, University of Medicine & Dentistry of New Jersey – New Jersey Medical School
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Section 2 - Cancer Symptom Mechanisms and Models: Clinical and Basic Science
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4 - The clinical science of cancer pain assessment and management
pp 18-30
- By Victor T. Chang, VA New Jersey Health Care System, Russell K. Portenoy, Beth Israel Medical Center
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5 - Pain: basic science
pp 31-31
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5a - Mechanisms of disease-related pain in cancer: insights from the study of bone tumors
pp 32-40
- By Juan Miguel Jimenez-Andrade, University of Arizona, Patrick W. Mantyh, University of Arizona
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5b - The physiology of neuropathic pain
pp 41-50
- By Haijun Zhang, The University of Texas M. D. Anderson Cancer Center, Patrick M. Dougherty, The University of Texas M. D. Anderson Cancer Center
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6 - Cognitive dysfunction: is chemobrain real?
pp 51-59
- By Christina A. Meyers, The University of Texas M. D. Anderson Cancer Center, Jeffrey S. Wefel, The University of Texas M. D. Anderson Cancer Center
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7 - Cognitive impairment: basic science
pp 60-69
- By Perry N. Fuchs, The University of Texas at Arlington, Jessica A. Boyette-Davis, The University of Texas M. D. Anderson Cancer Center, Adrian J. Dunn, University of Hawaii at Manoa
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8 - Depression in cancer: pathophysiology at the mind-body interface
pp 70-80
- By Michael A. Burke, Emory University School of Medicine, Charles L. Raison, Emory University School of Medicine, Andrew H. Miller, Emory University School of Medicine
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9 - Depressive illness: basic science
pp 81-81
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9a - Animal models of depressive illness and sickness behavior
pp 82-94
- By Adrian J. Dunn, University of Hawaii at Manoa
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9b - From inflammation to sickness and depression: the cytokine connection
pp 95-109
- By Robert Dantzer, University of Illinois, Keith W. Kelley, University of Illinois
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10 - Cancer-related fatigue: clinical science
pp 110-123
- By Xin Shelley Wang, The University of Texas M. D. Anderson Cancer Center
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11 - Developing translational animal models of cancer-related fatigue
pp 124-141
- By Mary W. Meagher, Texas A&M University
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12 - Cancer anorexia/weight loss syndrome: clinical science
pp 142-150
- By Nisha Lassi, Mayo Clinic, Rochester, Aminah Jatoi, Mayo Clinic, Rochester
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13 - Appetite loss/cachexia: basic science
pp 151-159
- By Tristin D. Brisbois Clarkson, University of Alberta, Wendy V. Wismer, University of Alberta, Vickie E. Baracos, University of Alberta
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14 - Sleep and its disorders: clinical science
pp 160-169
- By Lianqi Liu, University of California San Diego, Sonia Ancoli-Israel, University of California San Diego
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15 - Sleep and its disorders: basic science
pp 170-178
- By Mark R. Opp, University of Washington, Luca Imeri, University of Milan Medical School
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16 - Proteins and symptoms
pp 179-191
- By Bang-Ning Lee, The University of Texas M. D. Anderson Cancer Center, James M. Reuben, The University of Texas M. D. Anderson Cancer Center
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17 - Genetic approaches to treating and preventing symptoms in patients with cancer
pp 192-205
- By Qiuling Shi, The University of Texas M. D. Anderson Cancer Center, Charles S. Cleeland, The University of Texas M. D. Anderson Cancer Center
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18 - Functional imaging of symptoms
pp 206-223
- By T. Dorina Papageorgiou, Baylor College of Medicine, Javier O. Valenzuela, The University of Texas M. D. Anderson Cancer Center, Edward F. Jackson, The University of Texas M. D. Anderson Cancer Center
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19 - High-dose therapy and posttransplantation symptom burden: striking a balance
pp 224-236
- By Sergio A. Giralt, Memorial Sioan-Kettering Cancer Center, Loretta A. Williams, The University of Texas M. D. Anderson Cancer Center
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Measurement, Mechanisms, and Management

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