Development of the Ocular Lens

doi:10.1017/CBO9780511529825

This book provides a comprehensive view of research in lens developmental biology, emphasising technical and molecular breakthroughs. Elucidation of the mechanisms that govern lens development has enabled us to understand how the normal lens forms and how developmental processes are involved in the maintenance of its normal structure, function and growth throughout life. This knowledge is fundamental to our understanding of many lens disorders. The ocular lens has also become a model for understanding the developmental biology of more complex organ systems. In this 2004 book, leading experts in lens cell biology and development discuss lens evolution, induction, morphology, the regulation of the lens cell cycle and fiber cell differentiation, as well as lens regeneration. This book is an authoritative treatment of the subject that will serve as a reference for graduate students and research scientists in developmental biology and in the visual sciences, as well as for ophthalmologists.

"This volume is suitable and highly recommendable for all students and scientists in the eye field. the reference list is quite informative and I predict that this book will be a source of information for years to come." The Quarterly Review of Biology, Panagiotis A. Tsonis

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Contents

Frontmatter
pp i-iv
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Contents
pp v-viii
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List of Contributors
pp ix-xii
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Preface
pp xiii-xiv
- By Frank J. Lovicu, Senior Lecturer, Save Sight Institute and in the Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, Australia, Michael L. Robinson, Assistant Professor in the Department of Pediatrics, Ohio State University, USA
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Acknowledgments
pp xv-xvi
- By Frank J. Lovicu, Senior Lecturer, Save Sight Institute and in the Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, Australia, Michael L. Robinson, Assistant Professor in the Department of Pediatrics, Ohio State University, USA
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Part 1 - Early Lens Development
pp 1-2
- By Frank J. Lovicu, Senior Lecturer, Save Sight Institute and in the Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, Australia, Michael L. Robinson, Assistant Professor in the Department of Pediatrics, Ohio State University, USA
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1 - The Lens: Historical and Comparative Perspectives
pp 3-26
- By Michael L. Robinson, Assistant Professor in the Department of Pediatrics, Ohio State University, USA, Frank J. Lovicu, Senior Lecturer, Save Sight Institute and in the Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, Australia
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2 - Lens Induction and Determination
pp 27-47
- By Marilyn Fisher, Department of Biology, University of Virginia, Gilmer Hall, Robert M. Grainger, Department of Biology, University of Virginia, Gilmer Hall
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3 - Transcription Factors in Early Lens Development
pp 48-68
- By Guy Goudreau, Department of Molecular Cell Biology, Max-Planck-Institute of Biophysical Chemistry, Am Fassberg 11, 37070 Göttingen, Germany, Nicole Bäumer, Department of Medicine, Hematology and Oncology, University of Münster, Domagstr. 3, 48129 Münster, Germany, Peter Gruss, Department of Molecular Cell Biology, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Göttingen, Germany, phone: (49–551) 201 1361, fax: (49–551) 201 1504, e-mail: peter.grussmpg-gv.mpg.de
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Part 2 - The Lens
pp 69-70
- By Frank J. Lovicu, Senior Lecturer, Save Sight Institute and in the Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, Australia, Michael L. Robinson, Assistant Professor in the Department of Pediatrics, Ohio State University, USA
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4 - The Structure of the Vertebrate Lens
pp 71-118
- By Jer R. Kuszak, Departments of Pathology and Ophthalmology, Rush Presbyterian— St. Luke's Medical Center, 1653 W. Congress Parkway, Chicago, M. Joseph Costello, Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill
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5 - Lens Crystallins
pp 119-150
- By Melinda K. Duncan, Department of Biological Sciences, University of Delaware, 327 Wolf Hall, Newark, Ales Cvekl, Department of Ophthalmology and Visual Science and Department of Molecular Genetics, Albert Einstein College of Medicine, 713 Ullmann, 1300 Morris Park, Bronx, Marc Kantorow, Biomedical Sciences, Florida Atlantic University, Biomedical Sciences, Joram Piatigorsky, Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Building 7, Room 100A, 7 Memorial Drive MSC 0704, Bethesda
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6 - Lens Cell Membranes
pp 151-172
- By Joerg Kistler, School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand, Reiner Eckert, Department of Biophysics, Institute of Biology, University of Stuttgart, Pfaffenwaldring 57, D-70550 Stuttgart, Germany, Paul Donaldson, Department of Physiology, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
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7 - Lens Cell Cytoskeleton
pp 173-188
- By Roy Quinlan, Department of Biological Sciences, The Science Park, South Road, Durham, Alan Prescott, School of Life Sciences, MSIWTB, University of Dundee, Millers Wynd, Dundee
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Part 3 - Lens Development and Growth
pp 189-190
- By Frank J. Lovicu, Senior Lecturer, Save Sight Institute and in the Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, Australia, Michael L. Robinson, Assistant Professor in the Department of Pediatrics, Ohio State University, USA
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8 - Lens Cell Proliferation: The Cell Cycle
pp 191-213
- By Anne E. Griep, Department of Anatomy, University of Wisconsin Medical School, 1300 University Avenue, Madison, Pumin Zhang, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston
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9 - Lens Fiber Differentiation
pp 214-244
- By Steven Bassnett, Department of Ophthalmology and Visual Science, Washington University School of Medicine, 660 S. Euclid Ave. CB 8096, St. Louis, MO 63110–1093, USA, David Beebe, Department of Ophthalmology and Visual Science, Washington University School of Medicine, 660 S. Euclid Ave. CB 8096, St. Louis, MO 63110–1093, USA
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10 - Role of Matrix and Cell Adhesion Molecules in Lens Differentiation
pp 245-260
- By A. Sue Menko, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 571 Jefferson Alumni Hall, 1020 Locust St., Philadelphia, Janice L. Walker, Department of Pharmacology, University of Pennsylvania, 167 Johnson Pavillion, 3620 Hamilton Way, Philadelphia
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11 - Growth Factors in Lens Development
pp 261-289
- By Richard A. Lang, Divisions of Developmental Biology and Ophthalmology, Cincinnati Children's Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, John W. McAvoy, Save Sight Institute and Department of Anatomy and Histology, University of Sydney, Sydney Eye Hospital, Macquarie Street, GPO Box 4337, Sydney 2001, Australia
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12 - Lens Regeneration
pp 290-312
- By Katia Del Rio-Tsonis, Department of Zoology, Miami University, Oxford, Goro Eguchi, Chairman and President, Shokei Educational Institution, 2–6–78, Kuhonji, Kumamoto, 862–8678, Japan
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Bibliography
pp 313-386
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Index
pp 387-398
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Development of the Ocular Lens

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Contents

Frontmatter
pp i-iv

Contents
pp v-viii

List of Contributors
pp ix-xii

Preface
pp xiii-xiv

Acknowledgments
pp xv-xvi

Part 1 - Early Lens Development
pp 1-2

1 - The Lens: Historical and Comparative Perspectives
pp 3-26

2 - Lens Induction and Determination
pp 27-47

3 - Transcription Factors in Early Lens Development
pp 48-68

Part 2 - The Lens
pp 69-70

4 - The Structure of the Vertebrate Lens
pp 71-118

5 - Lens Crystallins
pp 119-150

6 - Lens Cell Membranes
pp 151-172

7 - Lens Cell Cytoskeleton
pp 173-188

Part 3 - Lens Development and Growth
pp 189-190

8 - Lens Cell Proliferation: The Cell Cycle
pp 191-213

9 - Lens Fiber Differentiation
pp 214-244

10 - Role of Matrix and Cell Adhesion Molecules in Lens Differentiation
pp 245-260

11 - Growth Factors in Lens Development
pp 261-289

12 - Lens Regeneration
pp 290-312

Bibliography
pp 313-386

Index
pp 387-398

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Development of the Ocular Lens

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