DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modeling

Pierre Baldi; G. Wesley Hatfield

doi:10.1017/CBO9780511541773

Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology.

Review of the hardback:'The book, written by Baldi and Hatfield, is an important and timely addition to the DNA microarray literature … the first several chapters of the book provide an easy-to-digest overview of the current state of DNA microarrays.'

Source: Briefings in Functional Genomics & Proteomics

Review of the hardback:‘Writing a book such as this was a challenging remit and one that the authors have achieved with great success.’

Source: Human Genomics

Review of the hardback:'I recommend very highly this book to statisticians in particular.'

Source: Journal of Statistical Computation & Simulation

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DNA Microarrays and Gene Expression

From Experiments to Data Analysis and Modeling

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Contents

Frontmatter
pp i-iv

Contents
pp v-vii

Preface
pp viii-xvi

1 - A brief history of genomics
pp 1-6

2 - DNA array formats
pp 7-16

3 - DNA array readout methods
pp 17-28

4 - Gene expression profiling experiments: Problems, pitfalls, and solutions
pp 29-52

5 - Statistical analysis of array data: Inferring changes
pp 53-72

6 - Statistical analysis of array data: Dimensionality reduction, clustering, and regulatory regions
pp 73-96

7 - The design, analysis, and interpretation of gene expression profiling experiments
pp 97-134

8 - Systems biology
pp 135-176

Appendix A - Experimental protocols
pp 177-184

Appendix B - Mathematical complements
pp 185-194

Appendix C - Internet resources
pp 195-198

Appendix D - CyberT: An online program for the statistical analysis of DNA array data
pp 199-206

Index
pp 207-213

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DNA Microarrays and Gene Expression

From Experiments to Data Analysis and Modeling

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