Contents

pp v-xiv

Preface

pp xv-xvii

List of Abbreviations

pp xviii-xx

Part I - Introduction and Background

pp 1-2

1 - Motivation and Outline

pp 3-8

2 - Biochemistry for Engineers: A Short Primer

pp 9-29

3 - Engineered Artificial Membranes

pp 30-58

Part II - Building Engineered Membranes, Devices, and Experimental Results

pp 59-60

4 - Formation of Engineered Tethered Membranes

pp 61-82

5 - Ion-Channel Switch (ICS) Biosensor

pp 83-102

6 - Physiochemical Membrane Platforms

pp 103-117

7 - Experimental Measurement Methods for Engineered Membranes

pp 118-136

Part III - Dynamic Models for Artificial Membranes: From Atoms to Device

pp 137-138

8 - Reaction-Rate-Constrained Models for Engineered Membranes

pp 139-158

9 - Reaction-Rate-Constrained Models for the ICS Biosensor

pp 159-173

10 - Diffusion-Constrained Continuum Models of Engineered Membranes

pp 174-211

11 - Electroporation Models in Engineered Artificial Membranes

pp 212-249

12 - Electroporation Measurements in Engineered Membranes

pp 250-281

13 - Electrophysiological Response of Ion Channels and Cells

pp 282-294

14 - Coarse-Grained Molecular Dynamics

pp 295-352

15 - All-Atom Molecular Dynamics Simulation Models

pp 353-389

16 - Closing Summary for Part III: From Atoms to Device

pp 390-392

Appendices

pp 393-394

Appendix A - Elementary Primer on Partial Differential Equations (PDEs)

pp 395-403

Appendix B - Tutorial on Coarse-Grained Molecular Dynamics with Peptides

pp 404-411

Appendix C - Experimental Setup and Numerical Methods

pp 412-420

Bibliography

pp 421-446

Index

pp 447-453