Fine-Tuning Life: A Guide to MicroRNAs, Your Genome's Master Regulators

David C. Henshall

doi:10.1017/9781009466400

Take a journey into the fascinating world of microRNA, the genome's master controllers. Discovered in 1993, our genome's master controllers are critical to the evolution of complex life, including humans. This captivating book tells their story, from their discovery and unique role in regulating protein levels to their practical applications in brain health and other branches of medicine. Written by a neuroscientist, it provides an in-depth look at what we know about microRNAs and how we came to know it. Explore the impact of these molecular conductors on your life and gain a new appreciation for the precision they bring to the molecular noise in our cells. Perfect for students of neuroscience, life sciences such as biochemistry and genetics and the curious public alike, this is the captivating tale of the conductors of life's molecular orchestra.

‘This is an outstanding book that clearly explains the discovery, functions, and applications of a biologically complex topic in a manner easily understandable by a wide audience. The author's expert knowledge of the subject matter comes through in this well written book.’

Mark F. Sanders Source: Doody's Reviews

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Contents

Fine-Tuning Life
pp i-i
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Reviews
pp ii-ii
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Fine-Tuning Life - Title page
pp iii-iii
A Guide to MicroRNAs, Your Genome’s Master Regulators
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Copyright page
pp iv-iv
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Dedication
pp v-vi
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Contents
pp vii-vii
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Figures
pp viii-viii
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Ode to the MicroRNA
pp ix-ix
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Acknowledgements
pp x-xii
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Common Terms and Definitions
pp xiii-xiv
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Introduction
pp 1-4
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Chapter 1 - Discovered!
pp 5-19
A New Regulator of Gene Activity
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Chapter 2 - MicroRNAs Emerge as Master Controllers
pp 20-47
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Chapter 3 - Epic Journey
pp 48-75
From Biogenesis to Extinction
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Chapter 4 - Opening Act
pp 76-107
Fine-Tuning During Development
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Chapter 5 - MicroRNAs Shape the Machinery of Our Minds
pp 108-139
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Chapter 6 - Centre of the Electrical Storm
pp 140-174
MicroRNAs and Epilepsy
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Chapter 7 - MicroRNAs Become Medicines
pp 175-210
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Chapter 8 - Circulating MicroRNAs Provide a Diagnosis
pp 211-231
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Chapter 9 - Finale and Encore for MicroRNAs
pp 232-244
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References
pp 245-263
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Index
pp 264-276
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Fine-Tuning Life

A Guide to MicroRNAs, Your Genome's Master Regulators

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Contents

Fine-Tuning Life
pp i-i

Reviews
pp ii-ii

Fine-Tuning Life - Title page
pp iii-iii

Copyright page
pp iv-iv

Dedication
pp v-vi

Contents
pp vii-vii

Figures
pp viii-viii

Ode to the MicroRNA
pp ix-ix

Acknowledgements
pp x-xii

Common Terms and Definitions
pp xiii-xiv

Introduction
pp 1-4

Chapter 1 - Discovered!
pp 5-19

Chapter 2 - MicroRNAs Emerge as Master Controllers
pp 20-47

Chapter 3 - Epic Journey
pp 48-75

Chapter 4 - Opening Act
pp 76-107

Chapter 5 - MicroRNAs Shape the Machinery of Our Minds
pp 108-139

Chapter 6 - Centre of the Electrical Storm
pp 140-174

Chapter 7 - MicroRNAs Become Medicines
pp 175-210

Chapter 8 - Circulating MicroRNAs Provide a Diagnosis
pp 211-231

Chapter 9 - Finale and Encore for MicroRNAs
pp 232-244

References
pp 245-263

Index
pp 264-276

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Fine-Tuning Life

A Guide to MicroRNAs, Your Genome's Master Regulators

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