Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis

doi:10.1017/CBO9780511545313

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

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Contents

Frontmatter
pp i-iv
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Contents
pp v-viii
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List of contributors
pp ix-xviii
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Preface
pp xix-xx
- By Ann Arvin, Professor of Pediatrics, Microbiology, and Immunology, Stanford University, Gabriella Campadelli-Fiume, Professor of Microbiology and Virology, University of Bologna, Italy, Edward Mocarski, Professor of Microbiology and Immunology, Emory University, Patrick Moore, Professor of Molecular Genetics and Biochemistry, University of Pittsburgh, Bernard Roizman, Professor of Molecular Genetics, Cell Biology, Biochemistry, and Molecular Biology, University of Chicago, Richard Whitley, Professor of Pediatrics, Microbiology, Medicine, and Neurosurgery, University of Alabama Birmingham, Koichi Yamanishi, Professor of Microbiology, Osaka University, Japan
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Part I - Introduction: definition and classification of the human herpesviruses
pp 1-2
- By Bernard Roizman, The Marjorie B. Kovler Viral Oncology Laboratories, The University of Chicago
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1 - Overview of classification
pp 3-9
- By Andrew J. Davison, MRC Virology Unit, Institute of Virology, Glasgow, UK
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2 - Comparative analysis of the genomes
pp 10-26
- By Andrew J. Davison, MRC Virology Unit, Institute of Virology, Glasgow, UK
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3 - Comparative virion structures of human herpesviruses
pp 27-43
- By Fenyong Liu, Division of Infectious Diseases School of Public Health University of California Berkeley, CA, USA, Z. Hong Zhou, Department of Pathology and Laboratory Medicine University of Texas-Houston Medical School Houston, TX, USA
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4 - Comparative analysis of herpesvirus–common proteins
pp 44-58
- By Edward S. Mocarski, Jr., Department of Microbiology & Immunology, Stanford University School of Medicine, CA, USA
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Part II - Basic virology and viral gene effects on host cell functions: alphaherpesviruses
pp 59-60
- By Gabriella Campadelli-Fiume, Department of Experimental Pathology, University of Bologna, Bernard Roizman, The Marjorie B. Kovler Viral Oncology Laboratories, The University of Chicago
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5 - Genetic comparison of human alphaherpesvirus genomes
pp 61-69
- By Joel D. Baines, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA, Philip E. Pellett, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH, USA
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6 - Alphaherpes viral genes and their functions
pp 70-92
- By Bernard Roizman, The Marjorie B. Kovler Viral Oncology Labs. The University of Chicago, IL, USA, Gabriella Campadelli-Fiume, Department of Experimental Pathology, University of Bologna, Italy
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7 - Entry of alphaherpesviruses into the cell
pp 93-111
- By Gabriella Campadelli-Fiume, Department of Experimental Pathology, Alma Mater Studiorum-University of Bologna, Italy, Laura Menotti, Department of Experimental Pathology, Alma Mater Studiorum-University of Bologna, Italy
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8 - Early events pre-initiation of alphaherpes viral gene expression
pp 112-127
- By Thomas M. Kristie, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
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9 - Initiation of transcription and RNA synthesis, processing and transport in HSV and VZV infected cells
pp 128-137
- By Rozanne M. Sandri-Goldin, Department of Microbiology & Molecular Genetics University of California, Irvine, CA, USA
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10 - Alphaherpesvirus DNA replication
pp 138-143
- By John Hay, Witebsky Center for Microbial Pathogenesis and Immunology, SUNY at Buffalo School of Medicine, NY, USA, William T. Ruyechan, Witebsky Center for Microbial Pathogenesis and Immunology, SUNY at Buffalo School of Medicine, NY, USA
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11 - Envelopment of HSV nucleocapsids at the inner nuclear membrane
pp 144-150
- By Joel D. Baines, Cornell University Department of Microbiology and Immunology, Ithaca, NY, USA
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12 - The egress of alphaherpesviruses from the cell
pp 151-162
- By Gabriella Campadelli-Fiume, Department of Experimental Pathology, Studiorum-University of Bologna, Italy
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13 - The strategy of herpes simplex virus replication and takeover of the host cell
pp 163-174
- By Bernard Roizman, The Marjorie B. Kovler Viral Oncology Laboratories, The University of Chicago, USA, Brunella Taddeo, The Marjorie B. Kovler Viral Oncology Laboratories, The University of Chicago, USA
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Part II - Basic virology and viral gene effects on host cell functions: betaherpesviruses
pp 175-176
- By Edward Mocarski, Department of Microbiology and Immunology, Emory University School of Medicine
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14 - Comparative betaherpes viral genome and virion structure
pp 177-203
- By Andrew J. Davison, MRC Virology Unit, Institute of Virology, Glasgow, UK, David Bhella, MRC Virology Unit, Institute of Virology, Glasgow, UK
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15 - Betaherpes viral genes and their functions
pp 204-230
- By Edward S. Mocarski, Jr., Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
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16 - Early events in human cytomegalovirus infection
pp 231-240
- By Teresa Compton, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, USA, Adam Feire, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, USA
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17 - Immediate–early CMV gene regulation and function
pp 241-263
- By Mark F. Stinski, Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA, Jeffery L. Meier, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
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18 - Early CMV gene expression and function
pp 264-294
- By Elizabeth A. White, Department of Cellular and Molecular Medicine and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA, USA, Deborah H. Spector, Department of Cellular and Molecular Medicine and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA, USA
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19 - CMV DNA synthesis and late viral gene expression
pp 295-310
- By David G. Anders, Division of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA, Julie A. Kerry, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, USA, Gregory S. Pari, Department of Microbiology and Immunology, University of Nevada-Reno, Reno, NV, USA
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20 - CMV maturation and egress
pp 311-323
- By William J. Britt, Department of Pediatrics, University of Alabama at Birmingham, AL, USA
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21 - CMV modulation of the host response to infection
pp 324-338
- By A. Louise McCormick, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford CA, Edward S. Mocarski, Jr., Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford CA
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Part II - Basic virology and viral gene effects on host cell functions: gammaherpesviruses
pp 339-340
- By Patrick S. Moore, Molecular Virology Program, University of Pittsburgh Cancer Institute Hillman Cancer Center
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22 - Introduction to the human γ-herpesviruses
pp 341-359
- By Richard Longnecker, Feinberg School of Medicine, Northwestern University Medical School, Chicago, IL, USA, Frank Neipel, Institute for Clinical and Molecular Virology, University of Erlangen, Germany
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Human Herpesviruses

Biology, Therapy, and Immunoprophylaxis

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