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    This book has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Uller, Tobias 2017. Book Review: Making Sense of Genes. Frontiers in Genetics, Vol. 8,


    Schmiemann, Philipp Nehm, Ross H. and Tornabene, Robyn E. 2017. Assessment of Genetics Understanding. Science & Education,


    Jamieson, Annie and Radick, Gregory 2017. Genetic Determinism in the Genetics Curriculum. Science & Education,


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    Making Sense of Genes
    • Online ISBN: 9781316422939
    • Book DOI: https://doi.org/10.1017/9781316422939
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Book description

What are genes? What do genes do? These seemingly simple questions are in fact challenging to answer accurately. As a result, there are widespread misunderstandings and over-simplistic answers, which lead to common conceptions widely portrayed in the media, such as the existence of a gene 'for' a particular characteristic or disease. In reality, the DNA we inherit interacts continuously with the environment and functions differently as we age. What our parents hand down to us is just the beginning of our life story. This comprehensive book analyses and explains the gene concept, combining philosophical, historical, psychological and educational perspectives with current research in genetics and genomics. It summarises what we currently know and do not know about genes and the potential impact of genetics on all our lives. Making Sense of Genes is an accessible but rigorous introduction to contemporary genetics concepts for non-experts, undergraduate students, teachers and healthcare professionals.

Reviews

'A beautifully and lucidly written book of great insights … I have not seen in one volume such clear analysis of the nuanced view of the 'gene' … A valuable book that gives genes a new and accurate meaning and does justice to understanding genetics in a non-reductive [manner] through a systems approach. The clarity, precision and insights are wonderful.'

Sheldon Krimsky - Tufts University, Massachusetts

'… an extremely intellectual and erudite treatment of the history and meaning of genes and genomes. The book is half hard-core genetics and half provocative and fascinating philosophy of science … cogently written, highly informative and genuinely thought-provoking.'

John Avise - University of California

'… it is really marvelous: very clearly written, very thoughtfully structured and marvellously sensitive to the needs of the reader, especially in providing 'take-home message' summaries just when and where they are most welcome. I especially admired the way the author consistently manages to help the reader dial down expectations when faced with hype about genetic tests and the latest 'gene for' discoveries.'

Gregory Radick - University of Leeds 

'There is a vast and curious mismatch between what biological science has discovered by empirical investigations on the mechanisms of heredity and the understanding of what appears to be the central concept, that of the gene. Despite careful attempts to show both the nature and the significance of this gap, the scientific media, and public perceptions of the concept, persistently follow a successfully popularized view that is not justified by what we now know. Kampourakis’ book is an excellent attempt to correct the situation … by bringing impressive scholastic skills to tackle the problem, the author has in my view made a very major contribution. The book deserves very wide attention.'

Denis Noble - University of Oxford

'Kampourakis provides an excellent critical analysis of the genetic discourse at the intersection of science and the public, based on the latest scientific findings from genomics and systems biology. The book fills an important gap in the literature in terms of the balance it keeps between accessibility and scientific rigour. It calls for a change in the ways students and the public are told what genes are and what they do, and it does so with compelling persuasiveness. A must-read, packed with convincing empirical material, for educators, journalists and academics who are critical of the usual 'gene for' talk, but do not want to give up on the fascinating insights that the science of genetics provides.'

Staffan Müller-Wille - University of Exeter

'… a wonderfully engaging and pedagogical explanation of difficult concepts in biology … Kampourakis has an incredible feeling for how to strike the balance between biological material and conceptual analysis. … If you are teaching life sciences or engaging in any form of public outreach, this book is a must-read. … Throughout, the material is wonderfully up to date … this important book will help us to explain genetics to our friends, students, and fellow academics.'

Tobias Uller Source: Frontiers in Genetics

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This section aims to provide suggestions for books that one might read in order to explore further the topics discussed in the present book. The list that follows is in no way exhaustive. For simplicity, only the main titles of the books are mentioned here; full details are provided in the list of references, where you will find a lot more books and articles that might be interesting.

If you want to read a single book in order to find out more about the distortions and myths about genes, as well as about the social implications of research in genetics, this should be Genetic Explanations, edited by Sheldon Krimsky and Jeremy Gruber. An older collection of this kind is The Double-Edged Helix edited by Joseph S. Alper, Catherine Ard, Adrienne Asch, Jon Beckwith, Peter Conrad, and Lisa N. Geller. Another relatively old but still very valuable account of the social implications of research in genetics is given in The Limits and Lies of Human Genetic Research by Jonathan Kaplan.

Several books have explicitly addressed, and argued against, genetic determinism. These include The DNA Mystique by Dorothy Nelkin and Susan Lindee; Exploding the Gene Myth by Ruth Hubbard and Elijah Wald; The Doctrine of DNA and The Triple Helix by Richard Lewontin; The Dependent Gene by David S. Moore; The Misunderstood Gene by Michel Morange; The Mirage of a Space between Nature and Nurture by Evelyn Fox Keller; and Genes, Cells and Brains by Hilary Rose and Stephen Rose. For the relation between nature and nurture, Evelyn Fox Keller’s book The Mirage of a Space between Nature and Nurture is the best one to start with. James Tabery’s Beyond Versus provides an interesting account of relevant historical controversies on this topic.

For an overview of the history of the gene concept, one could start with Evelyn Fox Keller’s The Century of the Gene. A very interesting book is The Gene: From Genetics to Postgenomics by Hans-Jörg Rheinberger and Staffan Müller-Wille, which presents a rich and concise account of the role that the gene concept has played in research. Another useful resource is the “Gene” entry by Hans-Jörg Rheinberger, Staffan Müller-Wille, and Robert Meunier in Stanford Encyclopedia of Philosophy. A more detailed account of the history of the gene concept is given in the book The Concept of the Gene in Development and Evolution, edited by Peter Beurton, Raphael Falk, and Hans-Jörg Rheinberger. For a philosophical account of genetics, a very good book is Genetics and Philosophy by Paul Griffiths and Karola Stotz. Another interesting book of this kind is What Genes Can’t Do by Lenny Moss. For philosophical accounts focusing on genomics research, the books Genomes and What to Make of Them by Barry Barnes and John Dupré, and Postgenomics, edited by Hallam Stevens and Sarah Richardson, will be rewarding readings.

The first histories of genetics were written by two researchers of the era of classical genetics. These are Alfred Sturtevant’s A History of Genetics and Leslie Dunn’s A Short History of Genetics. They were both published in 1965, on the centenary of the presentation of Mendel’s paper, and they are good places to start. Another overview of twentieth-century genetics is provided in Genetic Analysis by Raphael Falk, whereas a comprehensive overview is also given in the respective chapters of Jan Sapp’s Genesis. A very important resource that presents the study of heredity in its historical and cultural contexts is A Cultural History of Heredity by Staffan Müller-Wille and Hans-Jörg Rheinberger. Many classic books and papers of genetics are made available from Electronic Scholarly Publishing at www.esp.org. The journal Genetics also contains numerous “perspective” articles on the history of genetics.

There also exist excellent books for the various historical periods. For the pre-1900 period and the origins of mendelian genetics, the best book is definitely Robert Olby’s Origins of Mendelism. Another interesting book on this topic is The Mendelian Revolution by Peter Bowler. For the life and work of Mendel the most authoritative source are Vitezlav Orel’s writings, such as his book Mendel. A complete overview of classical genetics is given in Elof Axel Carlson’s Mendel’s Legacy. A detailed study of the work done by Morgan and his colleagues is Robert Kohler’s book Lords of the Fly. For the work of Morgan, one might also look at Garland Allen’s Thomas Hunt Morgan: the Man and His Science. The single best resource on eugenics is the book In the Name of Eugenics by Daniel Kevles. Diane Paul’s The Politics of Heredity and Controlling Human Heredity are also very useful resources. For the history of the emergence of genetic medicine from eugenics, two interesting books are Moments of Truth in Genetic Medicine by Susan Lindee, and The Science of Human Perfection by Nathaniel Comfort.

Coming to molecular biology, an amazing resource is the Eighth Day of Creation by Horace Freeland Judson, who wrote it based on interviews with most of the scientists involved. Michel Morange also gives a wide-ranging overview of the history of molecular biology in his likewise titled book. For the background and the events leading to the model of the double helix of DNA, one should read Robert Olby’s The Path to the Double Helix. For a detailed account of how the genetic code was solved, one should look at Lily Kay’s Who Wrote the Book of Life, and Matthew Cobb’s Life’s Greatest Secret. Finally, detailed and interesting narratives of the human genome project and of the development of companies producing genetic tests and DNA-sequencing machines are given in Cracking the Genome and in The $1000 Genome, respectively, both authored by Kevin Davies.

Several recent books provide accounts of current research in genomics. Kat Arney’s Herding Hemingway’s Cats provides an interesting account of recent findings about genes through interviews with several leading researchers. An accessible introduction to genetics that can also serve as a primer for the basics in molecular genetics is Genetic Twists of Fate by Stanley Fields and Mark Johnston. John Parrington’s The Deeper Genome is a very informative and very updated account of genomics research so far. Another useful resource on this topic is Nessa Carey’s Junk DNA.

Epigenetics is a recent and difficult-to-treat topic, because it differs from conventional textbook biology and because there is still a lot that we do not know. A nice, readable introduction is Epigenetics by Richard Francis. However, if you really want to understand the details without getting lost in them, the best book to start with is The Developing Genome by David Moore. Another interesting and detailed, but a bit more technical account, is given by Nessa Carey in The Epigenetics Revolution. For a broader discussion of nongenetic inheritance under an evolutionary perspective, an excellent book is Evolution in Four Dimensions by Eva Jablonka and Marion Lamb. For an introduction to evolutionary theory itself, and to the difficulties in understanding it, my book Understanding Evolution might be useful.

Genetics makes more sense in the light of development, and so it is absolutely necessary that one understands what development is and how it takes place. A very nice starting point is the book Life Unfolding by Jamie Davies, which provides a readable and accurate narrative of human development. A similarly readable account of human development and other aspects of human life is given in How We Live and Why We Die by Lewis Wolpert. Developmental Biology by the same author also provides a useful and brief account of various aspects of development in various organisms. A wonderful collection of philosophical accounts for genes in development and against gene centrism is Genes in Development edited by Eva Neumann-Held and Christoph Rehmann-Sutter.

There are many books about how to best handle the information the genetic and genomic tests might provide. Genomic Messages by George Annas and Sherman Elias provides both an updated account of the current issues at stake and sensible suggestions on how to deal with them. Other books are written by physicians and provide accounts of the struggles and questions that people have to face when making actual decisions about genetic testing. Two such books are Am I My Genes? by Robert Klitzman and The Age of Genomes by Steven Lipkin and Jon Luoma. An optimistic, but rather balanced and accessible, guide to genomic medicine is the book Genomics and Personalized Medicine by Michael Snyder.

Some broader reflection is crucial for understanding genetics research. Two excellent and highly readable books about how science is done are Stuart Firenstein’s Ignorance and Failure. Newton’s Apple and Other Myths about Science, edited by Ronald Numbers and me, includes short essays that debunk popular historical myths about science. If you want to understand probabilities and risks, Gerd Gigerenzer’s Calculated Risks is a very readable, accessible, and enjoyable account of the relevant issues. A similarly interesting and useful introduction to probabilities is The Improbability Principle by David Hand.

For those interested in reading the details of the respective research and scholarship, there are numerous citations in the main text of the present book that direct the reader to the lengthy list of references at the end of this book. The citations follow each point made, so the interested reader should read the article or book cited at the end of every argument or piece of evidence. Beyond that, the literature is enormous. If you really want to start exploring journals on genetics, it is best to start with reviews on the respective topics published in Nature Reviews Genetics, Cell, Nature and Science.

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