This work is a history of ideas, not a history of science. It uses the past to answer the questions of whether the Darwinian Revolution comes from ideas already prevalent in Victoria society – or is it a work of rebellion? – and whether the Darwinian Revolution was truly revolutionary – or is this a mistaken judgment made by historians and others?

For a book that attempts to explain how to understand visuals in life sciences, it seems prudent to first explain what we mean by “visual,” even if it may seem quite a common word.

In everyday conversation, “visual” is often used as an adjective and means “relating to seeing or sight,” as in “visual impression” or “visual effect.” In the context of this book, “visual” is used similarly as an adjective, but in addition, and more often, it is used as a noun. As a noun, it refers to the variety of images used in life science communication. For example, photographs are a type of visual commonly used in life science communication, and so are drawings.

The theory of evolution, as espoused by Charles Darwin in The Origin of Species in 1859, was difficult to accept for religious believers whose assumptions about the world were shattered by it, but Darwin’s The Descent of Man, published 12 years later, posed even greater challenges to people who did accept it, and those challenges continue today. It has often been noted that a disorienting consequence of the Enlightenment was to force people to recognize that humans were not created at the center of the universe in the image of God, but instead on a remote dust-speck of a planet, in the image of mold, rats, dogs, and chimps. For the entirety of recorded history, moral beliefs about humans had been based on the idea that people were in some fundamental sense apart from the rest of nature. Darwin disabused us of that notion once and for all. The scientific and social upheaval that has occurred since Darwin has been an extended process of coming to terms with a unification of humans and the rest of the natural world.

This opening chapter provides an overview of the future societal and subsequenl scientific challenges associated with population ageing. More specifically, it emphasizes how the field of biodemography constitutes a relevant framework for future research programmes aiming to address questions of paramount importance regarding both the causes (e.g. evolutionary, mechanistics) and consequences (demographic, medical) of the ageing process. Finally, this chapter details the book contents.

The origin of life could have involved autotrophy, but this is most probably chemolithotrophic rather than photolithotrophic. There is evidence, from the natural abundance of carbon isotopes, of autotrophy involving Rubisco and the Benson–Calvin–Bassham cycle from about 4 Ga. However, other autotrophic CO2 fixation pathways could also have occurred. Evidence on the evolution of photosynthetic reactions suggests an early origin of the photochemical reaction centre, with the possibility of the occurrence of two photosystems in series (photosystem II plus photosystem I) and the possibility of oxygenic photosynthesis, before the origin of the single photosystem (reaction centre I or reaction centre II) photosynthesis in the multiple clades of anoxygenic photosynthetic bacteria. The origin of photosystem II and photosystem I preceded the origin of cyanobacteria and the subsequent Great Oxidation Event at about 2.4–2.3 Ga. The occurrence of oxygenic photolithotrophy is a necessary, but not sufficient, condition for the occurrence of the Great Oxidation Event and the Neoproterozoic Oxidation Event. There is no consensus on what other factors are involved in initiating the Great Oxidation Event and the Neoproterozoic Oxidation Event.

Who does not know the most basic fact from the science of genetics, that peas and people reproduce in a similar fashion?

It is taught in high schools. Gregor Mendel discovered the fundamental scientific way that organisms breed, and it works the same way in people as it does in peas. Everyone knows that. They may not remember the specifics, with dominant uppercase A and recessive lowercase a – but they know that humans and peas reproduce basically the same way, because they were taught it, and it’s true.

Now I am certainly not going to try and convince you otherwise. But have you ever actually seen peas reproduce? Thanks to the internet, you can readily see videos of plant breeding. The videos of humans breeding, of course, are posted on more restricted internet sites.

The genome is the totality of information that directs the making and the maintenance of you and every other living organism. Scattered among the familiar genes that code for the proteins of life are other genes. This is a book about the genes we call microRNA. It is 30 years since their discovery. They are gene regulators, every bit as vital as their more famous gene cousins. MicroRNAs fine-tune how much protein is made in our cells, each one coordinating the activity of hundreds of genes and bringing precision to the ‘noise’ of gene expression. Without them, life is virtually impossible. This introduction provides a personal account of what fascinated the author about these genes enough to make him redirect his research to microRNAs. The journey from studying pharmacology in the UK, to the USA where his interest in the brain disease epilepsy began, and later to Dublin, to work at the Royal College of Surgeons in Ireland. It lays out the contents and style of the book, which is part history of science, describing what we know and the experiments that underpin our understanding, and part memoir of the author’s own research, and the applications of microRNAs in medicine.

Among the diversity of perspectives for studying the nexus of evolution and human behavior, human behavioral ecology (HBE) emerged as the study of the adaptive nature of behavior as a function of socioecological context. This volume explores the history and diversification of HBE, a field which has grown considerably in the decades since its emergence in the 1970s. At its core, the principles of HBE have remained a clear and cogent way to derive predictions about the adaptive function of behavior, even as the questions and methods of the discipline have evolved to be more interdisciplinary and more synergistic with other fields in the evolutionary social sciences. This introductory chapter covers core concepts, including methodological individualism, conditional strategies, and optimization. The chapter then provides an overview of the state of the field, including a summary of current research topics, areas, and methods. The chapter concludes by emphasizing the integral role that human behavioral ecology continues to play in deepening scholarly understandings of human behavior.

This chapter discusses distinctive features of Darwin’s theory of evolution, noting when they coincide with contemporary biology and when they depart. Darwin held ● that all life on earth today traces back to a common ancestor ● that natural selection is the main but not the exclusive cause of evolution ● that evolution is opportunistic, not pre-programmed ● that natural selection often causes traits to evolve because they help the organisms that have them to survive and reproduce, but sometimes selection causes traits to evolve because they help groups to avoid extinction and to found new daughter groups ● that evolution by natural selection is a gradual process ● that novel traits (now called mutations) have their causes, but they do not happen because they would be good for the organisms in which they occur ● that the distinction between species and sub-specific varieties is a matter of convention ● that middling phenotypes are usually fitter than phenotypes that are more extreme ● that traits acquired in the life-time of parents can be passed along as inherited characteristics to offspring.

The stone is still there in the garden. That’s what gets me. It’s not the house itself – houses decay slowly and can be preserved pretty easily, especially in Britain where even an eighteenth-century country house is not “old.” It’s not even the tree behind the house, alive when Charles Darwin still lived in his Down House, now propped up by guywires against inevitable collapse as a kind of totem of the great naturalist’s existence. If you leave the rear exit, the one that takes you to Darwin’s preserved greenhouse and the stunning flora on a pretty path lined in that particular English way of making the perfectly manicured seem somehow “natural,” you might glance to the left and see behind a small iron fence a one-foot-wide stone. A round mill stone or pottery wheel, it was, or appears to have been.

Ever since living beings arose from non-living organic compounds on a primordial planet, more than 3.5 billion years ago, a multitude of organisms has unceasingly flourished by means of the reproduction of pre-existing organisms. Through reproduction, living beings generate other material systems that to some extent are of the same kind as themselves. The succession of generations through reproduction is an essential element of the continuity of life. Not surprisingly, the ability to reproduce is acknowledged as one of the most important properties to characterize living systems. But let’s step back and put reproduction in a wider context, the endurance of material systems.

The view of living systems as machines is based on the idea of a fixed sequence of cause and effect: from genotype to phenotype, from genes to proteins and to life functions. This idea became the Central Dogma: the genotype maps to the phenotype in a one-way causative fashion, making us prisoners of our genes.

“Just the facts, ma’am. Just the facts!” This famous directive by Sergeant Joe Friday – apparently never actually made in this form – is from the television series Dragnet. Unfortunately, while this may be adequate for detecting and solving crime, not so elsewhere. The idea that science is simply a matter of recording empirical experience is hopelessly inadequate and misleading. Science is about empirical experience, but it is about such experience as encountered and interpreted – and with effort and good fortune – as explained by us.

There are several ‘enigmatic canid’ species in North America. One of them is the red wolf (Canis rufus, Figure 1.1), and another is the Great Lakes Wolf. Red wolves are seriously endangered, with a re-released population in North Carolina and breeding programmes being the last populations. Red wolves weren’t even studied closely until the 1960s, after having been hunted nearly to extinction in the nineteenth and twentieth centuries.

This chapter introduces some of the broader ideas and themes of the book, especially the importance of the scientific method as a route to understanding the material universe. It contrasts the scientific perspective with the perspectives in other academic and non-academic disciplines (e.g. the historical, religious, and moral perspectives on human behavior). It gives examples of the value of the scientific perspective, especially the fact that it does not allow for a privileged position, and that it is a relatively democratic form of knowledge. It discusss some historical objections to science, and also reviews some misuse of science, but also the types of topics science cannot address (morality, aesthetics, etc.).

On November 24, 1859, the English naturalist Charles Robert Darwin published On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life . In that book (Darwin 1859), he argued that all organisms, living and dead, were produced by a long, slow, natural process, from a very few original organisms. He called the process “natural selection,” later giving it the alternative name of “the survival of the fittest.” This first chapter is devoted to presenting (without critical comment) the argument of the Origin, very much with an eye to the place and role of natural selection. As a preliminary, it should be noted that the Origin, for all it is one of the landmark works in the history of science, was written in a remarkably “user-friendly” manner. It is not technical, the arguments are straightforward, the illustrative examples are relevant and easy to grasp, the mathematics is at a minimum, meaning non-existent. Do not be deceived. The Origin is also a very carefully structured piece of work (Ruse 1979a). Darwin knew exactly what he was doing when he set pen to paper.

For many millennia, humans have gazed up in wonder at the night-time sky. The full panoply of the Milky Way is an awesome sight. The scale of space is immense. Is there life out there somewhere? If so, where, and what form does it take? In the space of a couple of sentences, we’ve already gone from generalized wonder to specific questions. The next step is from questions to hypotheses, or, in other words, proposed answers. Here are two such hypotheses that I’ll flesh out as the book progresses: first, life exists on trillions of planets in the universe; second, it usually follows evolutionary pathways that are broadly similar to – though different in detail from – those taken on Earth.