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Most people who develop dementia will never be diagnosed, and therefore lack access to treatment and care from specialists in the field. This new edition provides updated guidance on how behavioral symptom reflect the changes occurring in the brain, and how these can help generalist clinicians to accurately diagnose neurodegenerative diseases. This practical book is aimed at healthcare professionals working in neurology, psychiatry and neuropsychology wanting to enhance the skills and knowledge needed to successfully manage these diseases. Simple approaches to bedside mental status testing, differential diagnosis and treatment, and interpreting neuropsychological testing and neuroimaging findings are covered. Introductory chapters outline dementia epidemiology and dementia neuropathology whilst chapters new to this edition describe the improvements in diagnostic capabilities in recent years, including blood based and cerebrospinal biomarkers and emerging biologically based therapies. Chapters on sleep disorders, and chronic traumatic encephalopathy and traumatic brain injury have also been expanded.
Neurosurgery is seen as 'inaccessible' to those on the outside, even though collaboration with a variety of non-neurosurgeons is essential to advancing the field. Thus, this book answers important questions for those interested in surgery of the brain: What is the current state of affairs? Where is the field going? And, importantly, how can I be involved? A work of far-reaching appeal, this book explores the evolution and future of brain surgery, detailing key technologies that have and will shape the field of neurosurgery. Readers are led on a journey covering over five thousand years of neurosurgical history, from trepanation in Neolithic France to the understanding of neuroanatomy and finally the technological leaps in the 20th and 21st centuries. Advances such as artificial intelligence, nanotechnology, microscopy, robotics are discussed by the world's leading experts, providing non-neurosurgical readers with a framework for how they can be involved in this thrilling field.
Catatonia is a complex neuropsychiatric disorder characterized by motor, affective and cognitive-behavioral symptoms, presenting significant challenges for both psychiatrists and neurologists. It occurs in 5–18% of patients in inpatient psychiatric units and in 3.3% of those in neurology or neuropsychiatric tertiary care inpatient settings. Despite its relatively high prevalence, catatonia is often underdiagnosed and inadequately treated, which can lead to substantial disadvantages for patients and may be associated with potentially life-threatening conditions. This comprehensive guide is designed to assist clinicians, researchers, and students in understanding and treating catatonia. It navigates through the history of the condition, exploring its phenomenology, clinical manifestations and pathophysiology, before delving into effective treatment strategies. By providing a clear and thorough overview, this guide simplifies the recognition of catatonia and promotes prompt and accurate treatment, encouraging future research endeavours in catatonia.
The EEG is a widely available neurophysiological test that, if interpreted correctly, provides valuable insight into brain function. Thoroughly revised for its second edition, this book demystifies their interpretation using a systematic approach that will benefit those looking to learn the art and science of EEG interpretation. Presented in three sections, the first delivers the foundational technical knowledge of how EEGs work, the second concentrates on a stepwise approach to analysing waveforms. The third section contains examples of EEGs in common scenarios, enabling readers to correlate their findings with clinical indications. Report writing is covered in depth in the appendix. Heavily illustrated with over 200 actual EEG examples, this is an essential handbook for all those seeking to learn and practice EEG reading. Perfect for residents, fellows, medical students on neurology/EEG electives, neurodiagnostic technologists, and experienced neurologists interested in an EEG refresher.
Diseases of the nervous system and muscles often cause problems with breathing, coughing and swallowing. Profound knowledge is required to interpret and treat these conditions correctly, while lack of it results in treatment decisions which are burdensome or outright dangerous for the patients. Taking the reader through the neuroanatomy and neurophysiology of breathing, swallowing and coughing, this comprehensive text clarifies the diagnosis and treatment of respiratory impairments from diseases of the brain, spinal cord, peripheral nervous system and muscles. Practical advice is offered on treatment in neurological, medical, intensive care and palliative care units as well as in rehabilitation and long-term care. Written by renowned neurologists, with decades of experience, clinicians and healthcare professionals working in neurology, pulmonology, anaesthesiology, intensive care and paediatrics will find this guide indispensable.
In this captivating memoir, Anne Buckingham Young shares her trailblazing journey in the male-dominated world of 20th century medicine towards becoming the first female chief at a major United States academic teaching hospital. Anne recounts her remarkable laboratory experiences identifying new neurotransmitters and their receptors. She shares her life with husband and collaborator Jack Penney, their quest to understand the brain circuits responsible for disorderly movements and their adventures in the hunt for the Huntington's disease gene with neuropsychologist Nancy Wexler. When Jack dies suddenly, Anne must confront her personal demons and a diagnosis of bipolar disorder. Through it all, Anne builds a cutting-edge research center, offering hope for new therapies for movement disorders and neurodegenerative diseases. This raw and honest portrayal is a testament to the power of perseverance and resilience. It is a must-read for anyone who has ever faced adversity and come out the other side stronger.
This essential, concept-oriented book provides a highly integrative and translational approach to addiction, offering a deep understanding of the condition and its close biological-causal-developmental linkage with mental illness. The book explains addiction around five fundamental components that define disease: 1) Population Impact; 2) Symptom Sets; 3) Disorder of Anatomical Structure and Function; 4) Biological Risk Amplification; and 5) Diagnosis and Treatment. Key evidence and concepts from basic neuroscience are translated to epidemiological, clinical-observational, and treatment levels. The book discusses the broad reach and potent clinical capabilities of addiction psychiatry teams using integrative diagnostics and multi-dimensional treatment plans for patients across the entire addiction-mental illness spectrum. It introduces science-based psychotherapies, therapeutic experiences, medication and neurostimulatory treatments used by addiction psychiatrists in different settings to advance patients through all stages of recovery. An illustrated foundation for advanced undergraduates, physicians, allied clinicians, and scientists entering brain-behavioural health fields.
The concept of doppelgänger, or 'double' – a conceived exact but sometimes invisible replica of a living person – has fascinated and intrigued people for centuries. This notion has a long history and is a widespread belief among cultural groups around the world. Doppelgängers have influenced literature and cinema, with writers such as Fyodor Dostoyevsky and Robert Louis Stevenson, and directors like Alfred Hitchcock exploring the phenomenon to great effect. This book brings together the literary and cinematic with empirical scientific literature to raise fundamental questions about the nature of the self and the human mind. It aims to establish the experience of the self and unravel the brain processes that determine bodily representation and the errors that make possible the experience of the doppelgänger phenomenon. This book will appeal to psychiatrists, neurologists, and neuroscientists, as well as interested general readers.
Neuroscience is increasingly understood to ground the practice of psychiatry, but clinicians can be overwhelmed by the competing facts and unfamiliar approaches utilised. This book provides key, up-to-date findings in neuroscience, and their relevance to clinical psychiatry in an approachable format. Clinical experts summarise the most important findings in diverse fields of neuroscience and explain their relevance for clinical practice. Topics include neuroanatomy, neurophysiology, neuropharmacology, and neurophilosophy, imparting essential knowledge for the MRCPsych syllabus and exams, as well as conveying important recent developments. Each chapter is designed to aid comprehension and learning with suggested readings, equipping the reader with the knowledge and skills to understand, assess, and treat those with mental health problems in the 21st Century. Expertly covering essential neuroscience topics with a clear emphasis on clinical relevance, this book is ideal for clinicians in psychiatry, psychology, and allied fields such as mental health nurses.
This concise, yet authoritative, clinical reference guide fulfils the needs of diverse clinicians, pharmacists and allied health professionals prescribing for Parkinson's disease and movement disorders in contemporary clinical practice. With chapters on newly approved drugs and their effects on motor and non-motor symptoms, information is also given on their use in particular populations including the elderly and patients with cognitive impairment. Each chapter includes pharmacological/biochemical rationale for drug use, a general guide to therapeutic use, pharmacokinetics, interaction profile, adverse effects, dosing and use, special population considerations, costs and value for money considerations, clinical vignette, a summary overview, and suggested reading. Ordered alphabetically and perfect for quick reference use, the guide is practical and essential for all prescribers with responsibility for patients with Parkinson's disease, including neurologists, geriatricians, internists, neurosurgeons, psychiatrists, family physicians, pharmacists as well as allied health professionals and resident, fellow, and student trainees in all related medical fields.
Your mental health is as important as your physical health and, in times of stress, it's vital to have enhanced cognition and reserves of resilience. This book is packed with practical tips, based on scientific evidence, that will teach you how to implement lifestyle strategies that will improve your brain health, cognition, and overall wellbeing. Covering the benefits of exercise, diet, sleep, social interactions, kindness, mindfulness, and learning, you will discover how adopting habits to improve these areas of your life at an early age will lead to a longer, healthier life. Embracing these simple strategies to prioritise your brain health and wellbeing is essential for a fulfilling life, with lifestyle choices playing a significant role in promoting resilience, creativity, and overall quality of life across all ages. For anyone seeking to lead a fulfilling life through happiness, health, and personal growth, this is the book for you.
A comprehensive and multidisciplinary guide to understanding and treating a wide range of movement disorders, including parkinsonisms, tremor, tics, dystonia, chorea, ballism and myoclonus. Split into five sections, the first is a basic introduction to the subject, covering the principles of human motor behavior and functional anatomy. The next three sections discuss movement disorders in depth, grouped into hypokinetic, hyperkinetic, and dyscoordinative and otherwise inappropriate motor behaviours, covering clinical manifestations, diagnostic features and therapeutic strategies. The last section explores the different ways of objectifying selected behavioral movement disorders. 90 videos, hosted online, and over 200 figures illustrate the concepts covered in the book, offering a visual reference for the disorders discussed. This compendium offers an essential tool to recognize, interpret and understand the clinical manifestations and underlying disorders of neurological movement disorders, and to select the best therapeutic strategies.
Based on Dr Colin Espie's 45 years of clinical and research experience, this expert manual for clinicians and healthcare professionals shows how best to assess insomnia and deliver effective treatment in everyday practice using cognitive and behavioural therapeutics (CBTx). The book provides in-depth background on the importance of sleep, the interactions between sleep and health, what insomnia is, and insomnia's negative impact on patients. Using detailed examples, metaphors, and practical guidance, it provides clear instructions on the evaluation of sleep complaints and on the why and how of selecting and providing a specific CBTx to suit the presenting patient. Delving beyond treating patients at the individual level, the book also considers how to develop an effective and efficient insomnia service at population scale.
There are unique challenges to the care of women with epilepsy, including the gender-specific influences that women may experience owing to their age, hormonal status, and co-morbidities. Many healthcare providers are not informed about the unique issues facing women with epilepsy. This new edition comprehensively reviews the impacts of epilepsy at different life-stages, from adolescence, through pregnancy and to menopause, highlighting appropriate therapies. The book covers topics including managing patients' fertility and preconception counselling, obstetric and fetal monitoring and post-partum seizure management. Chapters on drug-drug interactions, the effect of hormones and anti-epileptic drugs have been thoroughly updated according to new guidelines. Information is presented practically, with bullet points allowing readers to access take home messages easily. This is a highly practical, up-to-date and concise manual for the practical approach in caring for women with epilepsy aimed at general practitioners, midwives, obstetricians, general neurologists, and anesthetists.
There are over 800 neuromuscular disorders and this can leave clinicians feeling lost as they try to diagnose and manage patients. On the basis of 66 adult and paediatric neuromuscular case vignettes, readers will be walked through using case histories and clinical manifestations as a starting point for diagnosis. For each case, diagnostic tools, disease pathogenesis, prognosis and treatment options are discussed. Symptoms, signs and syndromes are cross-linked to help the reader navigate the array of disorders. Accompanying tables explain differential diagnoses and 30 videos demonstrate clinical features. This second edition has been thoroughly updated as the neuromuscular subspecialty has developed from clinically and pathologically descriptive to making use of new diagnostic technologies and therapies. Neurologists at all levels, paediatricians, internists, geneticists, rehabilitation physicians, physiotherapists and researchers in the field will find this an invaluable guide, as they seek to familiarise themselves with this complex range of disorders.
If you love neuroanatomy, chances are that you also love a good puzzle. Providing a fun and refreshing alternative method of learning and reviewing neuroanatomical structures, this engaging book is perfect for those who love both neuroanatomy and riddles. 150 four-line riddles describe specific high-yield neuroanatomical structures in cryptic form. These could be lobes or general regions of the brain, blood vessels supplying key neurological structures, specific anatomical brain structures, or neuroanatomical spaces and passages. Hints such as general location in the body, the structure's function or dysfunction if impaired, or its Latin or Greek name origin are incorporated. On the following page from each riddle, the answer is given along with a complete description of the structure, history of the structure, clinical correlation and more key information For even more challenging neuroscience puzzles, consider the Neurology Riddle Book, which includes riddles about neurological syndromes, conditions and diseases.
If you love neurology, chances are that you also love a good puzzle. Providing a fun and refreshing alternative method of learning and reviewing neurological syndromes, conditions and diseases, this engaging book is perfect for those who love both neurology and riddles. 150 four-line riddles describe common neurodegenerative diseases and movement disorders as well as rare but commonly board-tested stroke syndromes, seizure disorders and infectious diseases. Each riddle contains cryptic clues such as patient demographic, clinical presentation and underlying pathophysiology for each condition and there are hints in case you get stuck. On the following page you will find the answer to the riddle along with a complete description of the condition, including the history of the disease, pathophysiology, clinical presentation, diagnostics, treatment and prognosis to aid learning. For even more challenging neuroscience puzzles, consider the Neuroanatomy Riddle Book, which includes riddles about clinically-relevant neuroanatomical structures.
Neuroprognostication in patients with primary neurological diagnoses as well as in critically ill patients with concomitant neurological diagnoses is increasingly complex. With advances in critical care, the focus of the field is progressively moving from survivorship to improving patients' quality of life. This evidence-based resource provides an in-depth analysis of different aspects of prognostication in neurologically critically ill patients, covering how to gather the correct data and synthesize this information at the bedside. Delving into disease specific prognostication such as traumatic brain injury, acute ischemic stroke and delirium, guidance is provided for choosing management strategies based on overall perception of prognostication and shared decision making. Other topics covered include religious and legal issues, palliative care, chronic critical illness and new frontiers including machine learning and biomarkers usage. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed inside the cover.
The applications and advantages of portable pupillometry for a wide variety of healthcare providers are becoming increasingly evident, with frequent pupil evaluation becoming the protocol throughout critical care and emergency departments. Authored by a world leading expert, this practical, user-friendly book brings together all the research on portable pupillometry and explains the meaning of the various parameters that new portable pupillometers provide. Starting with the anatomy and physiology of the pupil, the book moves on to discuss pharmacological effects, unusual pupillary syndromes, measurement and size of the pupil, pupillary reflex dilation and pupillary unrest. Additional chapters focus on traumatic brain injury, cardiac arrest, intensive care, opioid effect, acute pain and anisocoria and provide valuable clinical examples and case reports. Also featuring an extensive bibliography for further reading, this book is essential reading for all healthcare professionals using the pupil to evaluate drug effects and ischemic/traumatic insults to the brain.
Take a journey into the fascinating world of microRNA, the genome's master controllers. Discovered in 1993, our genome's master controllers are critical to the evolution of complex life, including humans. This captivating book tells their story, from their discovery and unique role in regulating protein levels to their practical applications in brain health and other branches of medicine. Written by a neuroscientist, it provides an in-depth look at what we know about microRNAs and how we came to know it. Explore the impact of these molecular conductors on your life and gain a new appreciation for the precision they bring to the molecular noise in our cells. Perfect for students of neuroscience, life sciences such as biochemistry and genetics and the curious public alike, this is the captivating tale of the conductors of life's molecular orchestra.