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Observer-rated retardation but not agitation corresponds to objective motor measures in depression

Published online by Cambridge University Press:  30 July 2018

Linda van Diermen*
Affiliation:
Department of Biomedical Sciences, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerpen, Belgium University Department, Psychiatric Hospital Duffel, Duffel, Belgium
Sebastian Walther
Affiliation:
Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland
Olivia Cools
Affiliation:
Department of Biomedical Sciences, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerpen, Belgium University Department, Psychiatric Hospital Duffel, Duffel, Belgium
Erik Fransen
Affiliation:
StatUa Center for Statistics, University of Antwerp, Antwerpen, Belgium
Tom K. Birkenhäger
Affiliation:
Department of Biomedical Sciences, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerpen, Belgium Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands
Bernard C.G. Sabbe
Affiliation:
Department of Biomedical Sciences, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerpen, Belgium University Department, Psychiatric Hospital Duffel, Duffel, Belgium
Didier Schrijvers
Affiliation:
Department of Biomedical Sciences, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerpen, Belgium University Department, Psychiatric Hospital Duffel, Duffel, Belgium
*
Author for correspondence: Linda van Diermen, University Department, Psychiatric Hospital Duffel, Stationsstraat 22c, 2570 Duffel, Belgium. Tel: +32 (0)15 30 40 34; Fax: +32 (0)15 30 40 47; E-mail: linda.vandiermen@uantwerpen.be

Abstract

Objective

To explore the correlations between observer ratings and instrumental parameters across domains of psychomotor functioning in depression.

Method

In total, 73 patients with major depressive disorder underwent extensive psychomotor and clinical testing. Psychomotor functioning was assessed with (i) an observer-rated scale (the CORE measure) and also objectively with (ii) 24-h actigraphy, and (iii) a fine motor drawing task.

Results

Observer ratings of retardation correlated with instrumental assessments of fine and gross motor functioning. In contrast, observer ratings of agitation did not correlate with observer ratings of retardation or with the instrumental measures. These associations were partly influenced by age and, to a lesser extent, by depression severity.

Conclusion

Psychomotor disturbance is a complex concept with different manifestations in depressed patients. Although observer ratings of retardation correspond well with instrumental measures of the motor domains, objective measurement of agitation and other aspects of psychomotor disturbance require further research.

Type
Short Communication
Copyright
© Scandinavian College of Neuropsychopharmacology 2018 

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Observer-rated retardation but not agitation corresponds to objective motor measures in depression
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