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Associations between autistic-like traits and polymorphisms in NFKBIL1

Published online by Cambridge University Press:  04 June 2019

Nina Strenn Open the ORCID record for Nina Strenn [Opens in a new window] ,
Daniel Hovey ,
Lina Jonsson ,
Henrik Anckarsäter ,
Sebastian Lundström ,
Paul Lichtenstein  and
Agneta Ekman
Nina Strenn*
Affiliation:
Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Daniel Hovey
Affiliation:
Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Lina Jonsson
Affiliation:
Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Henrik Anckarsäter
Affiliation:
Centre for Ethics, Law and Mental Health (CELAM), University of Gothenburg, Gothenburg, Sweden
Sebastian Lundström
Affiliation:
Centre for Ethics, Law and Mental Health (CELAM), University of Gothenburg, Gothenburg, Sweden Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden
Paul Lichtenstein
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Agneta Ekman
Affiliation:
Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
*
Author for correspondence: Nina Strenn, Email: nina.strenn@neuro.gu.se
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Abstract

Objective:

The immune system has been suggested to be associated with neuropsychiatric disorders; for example, elevated levels of cytokines and the inflammation-related transcription factor nuclear factor kappa-B (NF-κB) have been reported in individuals with autism spectrum disorder (ASD). The aim of this study was to investigate possible associations between autistic-like traits (ALTs) and single nucleotide polymorphisms (SNPs) in NFKB1 (encoding a subunit of the NF-κB protein complex) and NF-κB inhibitor-like protein 1 (NFKBIL1).

Methods:

The study was conducted in a cohort from the general population: The Child and Adolescent Twin Study in Sweden (CATSS, n = 12 319, 9–12 years old). The subjects were assessed by the Autism-Tics, ADHD, and Other Comorbidities Inventory. Five SNPs within the two genes were genotyped (NFKBIL1: rs2857605, rs2239707, rs2230365 and rs2071592; NFKB1: rs4648022).

Results:

We found significant associations for two SNPs in NFKBIL1: rs2239707 showed a significant distribution of genotype frequencies in the case-control analysis both for all individuals combined and in boys only, and rs2230365 was significantly associated with the ALTs-module language impairment in boys only. Furthermore, we found nominal association in the case-control study for rs2230365, replicating earlier association between this SNP and ASD in an independent genome-wide association study.

Conclusion:

The shown associations between polymorphisms in NFKBIL1 and ALTs are supporting an influence of the immune system on neuropsychiatric symptoms.

Keywords

autistic disordersimmune systempolymorphismsingle nucleotide
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 31 , Issue 4 , August 2019 , pp. 220 - 229
Copyright
© Scandinavian College of Neuropsychopharmacology 2019 

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