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BDNF and NRG1 polymorphisms and temperament in selective serotonin reuptake inhibitor-treated patients with major depression

Published online by Cambridge University Press:  09 January 2018

Kadri Andre ,
Olli Kampman ,
Merja Viikki ,
Eija Setälä-Soikkeli ,
Ari Illi ,
Nina Mononen ,
Terho Lehtimäki  and
Esa Leinonen
Kadri Andre*
Affiliation:
Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
Olli Kampman
Affiliation:
Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland Department of Psychiatry, Seinäjoki Hospital District, Seinäjoki, Finland
Merja Viikki
Affiliation:
Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland Tampere City Mental Health Care Center, Tampere, Finland
Eija Setälä-Soikkeli
Affiliation:
Department of Psychiatry, Kanta-Häme Hospital District, Hämeenlinna, Finland
Ari Illi
Affiliation:
Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
Nina Mononen
Affiliation:
Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland Fimlab Laboratories, Tampere, Finland
Terho Lehtimäki
Affiliation:
Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland Fimlab Laboratories, Tampere, Finland
Esa Leinonen
Affiliation:
Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland Department of Psychiatry, Tampere University Hospital, Tampere, Finland
*
Kadri Andre, Selkäsuonkatu 11 E 6, Hämeenlinna 13100, Finland. Tel: +358440545954; E-mail: kadri.andre@gmail.com
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Abstract

Objective

We investigated the separate effects of and possible interactions between the functional polymorphisms of brain-derived neurotrophic factor (BDNF) rs11030101, BDNF rs61888800, and neuregulin-1 (NRG1) rs3924999 and NRG1 rs6994992 on change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment for a period of 6 weeks.

Methods

The study population consisted of 98 Finnish individuals with MDD. They were assessed by the 107-item Temperament and Character Inventory temperament questionnaire (version IX) and the Montgomery–Åsberg Depression Rating Scale (MADRS). In general linear univariate models (GLM) for novelty seeking (NS) or reward dependence (RD) change age, gender, MADRS score change and BDNF and NRG1 genotypes were used as explaining explanatory variables.

Results

Mean comparisons between corresponding temperament dimensions and genotypes showed significant differences between NS change and BDNF rs61888800 T-carrying status (mean difference: GG 0.30, GT/TT 2.47, p=0.022, t-test) and between RD change and NRG1 rs3924999 A-carrying status (mean difference: GG 1.21, GA/AA −0.33, p=0.003). In GLM models for NS change the significant predictors comprised BDNF rs61888800 T-carrying status, age and MADRS score change (model 1), and additionally NRG1 rs6994992 T-carrying status (model 2). For RD change the predictors included NRG1 rs3924999 A-carrying status, age and MADRS score change (model 1) and additionally gender (model 2).

Conclusion

According to the current results both BDNF and NRG1 are associated with temperament traits during depression. These results warrant further studies regarding the impact of this association on depression recovery.

Keywords

brain-derived neurotrophic factordepressionneuregulin-1temperament
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 30 , Issue 3 , June 2018 , pp. 168 - 174
Copyright
© Scandinavian College of Neuropsychopharmacology 2018 

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