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A case-control study of interleukin-12 1188A/C polymorphism in obsessive-compulsive disorder in Chinese population

  • Shiguo Liu (a1) (a2) (a3), Yanhui Liu (a4), Yingying Yin (a4), Xinhua Zhang (a4) and Xu Ma (a5) (a6) (a7)...

Objective: Previous studies indicated that the levels of serum interleukin (IL)-12 at baseline were elevated in obsessive-compulsive disorder (OCD) patients compared with control subjects, suggesting that IL-12 maybe involved in the etiopathogenesis of OCD. Therefore, we study the relationship between 1188A/C polymorphism of IL-12(rs3212227) and OCD in Chinese Han population.

Methods: We genotyped 194 OCD patients and 322 healthy individuals by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), then analyzed the data using case-control association test.

Results: No significant differences were found in 1188A/C genotypic and allelic frequencies between OCD cases and controls (X2 = 2.12, df = 2, P = 0.35 by genotype; X2 = 0.005, df = 1, P = 0.94 by allele).

Conclusions: Our results suggested that there may be lack of an association between OCD and IL-12 1188A/C polymorphism in Chinese Han population.

Corresponding author
Xinhua Zhang, MD, Department of psychiatry, Medical College, Qingdao University, 16 Jiangsu Road, Qingdao 266003, China. Tel: +86 053282912012; Fax: +86 053282912016; E-mail:
Professor Xu Ma, Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081 China. Tel: +86 10 62176870; Fax: +86 10 62179151; E-mail:
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Acta Neuropsychiatrica
  • ISSN: 0924-2708
  • EISSN: 1601-5215
  • URL: /core/journals/acta-neuropsychiatrica
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