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Cognitive performance following fluoxetine treatment in depressed patients post myocardial infarction

Published online by Cambridge University Press:  24 June 2014

Jacqueline J. M. H. Strik ,
Adriaan Honig ,
Edwin Klinkenberg ,
Jeanette Dijkstra  and
Jelle Jolles
Jacqueline J. M. H. Strik*
Affiliation:
Department of Psychiatry, University Hospital Maastricht/University of Maastricht, The Netherlands
Adriaan Honig
Affiliation:
Department of Psychiatry, University Hospital Maastricht/University of Maastricht, The Netherlands
Edwin Klinkenberg
Affiliation:
Department of Psychiatry, University Hospital Maastricht/University of Maastricht, The Netherlands
Jeanette Dijkstra
Affiliation:
Department of Psychiatry, University Hospital Maastricht/University of Maastricht, The Netherlands
Jelle Jolles
Affiliation:
Department of Psychiatry, University Hospital Maastricht/University of Maastricht, The Netherlands
*
Jacqueline Strik, MD, PhD, RIAGG Maastricht, Parallelweg 45/47, 6221 BD Maastricht, The Netherlands. Tel: +31 43 3299699; Fax: +31 43 3299656; E-mail: jacqueline.strik@np.unimaas.nl
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Abstract

Background:

As depression is a considerable risk factor for an unfavourable course of myocardial infarction (MI), antidepressant treatment of post-MI depression and, inherent to MI status, polypharmacy has become an important issue.

Objective:

The present study is the first to evaluate cognitive side effects of fluoxetine, as part of a placebo-controlled double-blind trial, in patients with post-first MI depression.

Methods:

Cognitive performance of 54 depressed patients post first-MI, treated with fluoxetine or placebo was compared. Cognitive performance was tested before and after 9 weeks of treatment using the Visual Verbal Learning Test, Concept Shifting Task, Stroop Colour-Word Test and Letter-Digit-Substitution Test.

Results:

The median number of cardiovascular drugs taken by MI patients was 4.9. There were no differences between the fluoxetine and the placebo group on cognitive performance.

Conclusion:

In sum, there were no negative side effects of fluoxetine compared with placebo on cognition in depressed MI patients, simultaneously treated with cardiac drugs.

Keywords

cognitiondepressionfluoxetinemyocardial infarctionside effects
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 18 , Issue 1 , February 2006 , pp. 1 - 6
Copyright
Copyright © 2006 Blackwell Munksgaard

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