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Decreased beta 1 (12–15 Hertz) power modulates the transfer of suicidal ideation to suicide in major depressive disorder

Published online by Cambridge University Press:  22 August 2023

Chenguang Jiang ,
Zixuan Huang ,
Zhenhe Zhou ,
Limin Chen  and
Hongliang Zhou Open the ORCID record for Hongliang Zhou [Opens in a new window]
Chenguang Jiang
Affiliation:
Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu Province, China
Zixuan Huang
Affiliation:
Department of Music and Wellbeing, School of Music, University of Leeds, Leeds, UK
Zhenhe Zhou
Affiliation:
Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu Province, China
Limin Chen*
Affiliation:
Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu Province, China
Hongliang Zhou*
Affiliation:
Department of Clinical Psychology, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, China
*
Corresponding authors: Limin Chen; Email: scoatt@163.com; Hongliang Zhou; Email: Hongliangzh2022@hotmail.com
Corresponding authors: Limin Chen; Email: scoatt@163.com; Hongliang Zhou; Email: Hongliangzh2022@hotmail.com
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Abstract

Background:

Suicide prevention for major depressive disorder (MDD) is a worldwide challenge, especially for suicide attempt (SA). Viewing suicide as a state rather than a lifetime event provided new perspectives on suicide research.

Objective:

This study aimed to verify and complement SAs biomarkers of MDD with a recent SA sample.

Methods:

This study included 189 participants (60 healthy controls; 47 MDD patients with non-suicide (MDD-NSs), 40 MDD patients with suicide ideation (MDD-SIs) and 42 MDD patients with SA (MDD-SAs)). MDD patients with an acute SA time was determined to be within 1 week since the last SA. SUICIDALITY Part in MINI was applied to evaluate suicidality. Absolute powers in 14 frequency bands were extracted from subject’s resting-state electroencephalography data and compared within four groups. The relationship among suicidality, the number of SA and powers in significant frequency bands were investigated.

Results:

MDD-SIs had increased powers in delta, theta, alpha and beta band on the right frontocentral channels compared to MDD-NSs, while MDD-SAs had decreased powers in delta, beta and gamma bands on widely the right frontocentral and parietooccipital channels compared to MDD-SIs. Beta 1 power was the lowest in MDD-SAs and was modulated by the number of SA. The correlation between suicidality and beta 1 power was negative in MDD-SAs and positive in MDD-SIs.

Conclusion:

Reduced beta 1 (12–15 Hz) power could be essential in promoting suicidal behaviour in MDD. Research on recent SA samples contributes to a better understanding of suicide mechanisms and preventing suicidal behaviour in MDD.

Keywords

Recent suicide attemptsuicide ideationbeta 1 absolute powerelectroencephalogrammajor depressive disorder
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 35 , Issue 6 , December 2023 , pp. 362 - 371
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology

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