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Differential impairment of working memory performance in first-degree relatives of individuals with schizophrenia

  • Aaron R. Kent (a1) (a2) (a3), Allison M. Fox (a2) (a3), Patricia T. Michie (a1) (a2) (a3) and Assen V. Jablensky (a1)
Abstract
<span class='bold'>Background:</span>

Numerous studies have reported neuropsychological impairment in schizophrenia and increasing evidence suggests that individuals with schizophrenia or schizophrenia spectrum disorders and their unaffected first-degree family members exhibit similar deficits in some neuropsychological domains. Substantial modifications to the Wechsler Memory Scale (WMS) have resulted in more sensitive and reliable indicators of various aspects of memory functioning in the WMS-III, which enables generation of auditory, visual and working memory indices.

<span class='bold'>Objective:</span>

The aim of the present study was to examine the memory profile of individuals with schizophrenia or schizophrenia spectrum disorder (n = 19), their unaffected first-degree family members (n = 11), and healthy controls (n = 9).

<span class='bold'>Methods:</span>

The study involved neuropsychological testing, including the immediate and working memory subtests of the WMS-III, utilizing both auditory and visual domains. Symptom assessment was performed using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN), version 2.0. Two multivariate analyses of covariance (mancova) were conducted: (i) comparing patients, relatives and controls; and (ii) comparing relatives and controls only.

<span class='bold'>Results:</span>

The first analysis indicated that the patient group obtained significantly lower index scores than both relatives and controls on all three indices. The second analysis indicated that the performance of relatives was significantly lower than controls on the working memory index, although there were no significant differences on the auditory and visual immediate index scores.

<span class='bold'>Conclusions:</span>

The differential impairment in working memory performance in clinically asymptomatic family members suggests that the WMS-III working memory index score may be a potential phenotypic marker of schizophrenia.

Copyright
Corresponding author
Aaron Kent, Centre for Clinical Research in Neuropsychiatry, Gascoyne House Graylands Hospital, Private Mail Bag no. 1, Mt Claremont 6010, Australia. Tel: + 61 (8) 9347 6429; Fax: + 61 (8) 9384 5128; E-mail: aaron@ccrn.uwa.edu.au
References
Hide All
1.Barch DM, Carter CS. Selective attention in schizophrenia: Relationship to verbal working memory. Schizophr Res 1998;33: 5361.
2.Cannon TD, Huttenen MO, Lonnquist Jet al. The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet 2000;67: 369382.
3.Egan MF, Goldberg TE, Kolachana BSet al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001;98: 69176922.
4.Abi-Dargham A, Mawlawi O, Lombardo Iet al. Prefrontal dopamine D1 receptors and working memory in schizophrenia. J Neurosci 2002;22: 37083719.
5.Hallmayer JF, Jablensky AV, Michie PTet al. Linkage analysis of candidate regions using a composite neurocognitive phenotype correlated with schizophrenia. Mol Psychiatry 2003;8: 511523.
6.Gold JM, Randolph C, Carpenter CJ, Goldberg TE, Weinberger DR. Forms of memory failure in schizophrenia. J Abnorm Psychol 1992;101: 487494.
7.McKenna PJ, Tamlyn D, Lund CE, Mortimer AM, Hammond S, Baddeley AD. Amnesic syndrome in schizophrenia. Psychol Med 1990;20: 967972.
8.Goldman-Rakic PS. Functional architecture of working memory and disordered cognition in schizophrenia. Biol Psychiatry 1999;46: 650661.
9.Callicott JH, Bertolino A, Mattay VSet al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex 2000;10: 10781092.
10.Weinberger DR, Egan MF, Bertolino Aet al. Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 2001;50: 825844.
11.Baddeley A. Working Memory. Oxford, England: Claredon Press, 1986.
12.Perry W, Heaton RK, Potterat E, Roebuck T, Minassian A, Braff DL. Working memory in schizophrenia: transient ‘online’ storage versus executive functioning. Schizophr Bull 2001;27: 157176.
13.Goldberg TE, Torrey EF, Gold JM, Ragland JD, Bigelow LB, Weinberger DR. Learning and memory in monozygotic twins discordant for schizophrenia. Psychol Med 1993;23: 7185.
14.Conklin HM, Curtis CE, Katsanis J, Iacono WG. Verbal working memory impairment in schizophrenia patients and their first-degree relatives: evidence from the digit span task. Am J Psychiatry 2000;157: 275277.
15.Goldberg TE, Weinberger DR. Thought disorder, working memory and attention: interrelationships and the effects of neuroleptic medications. Int Clin Psychopharmacol 1995;10: 99104.
16.Kremen WS, Seidman LJ, Pepple JR, Lyons MJ, Tsuang MT, Faraone SV. Neuropsychological risk indicators for schizophrenia: a review of family studies. Schizophr Bull 1994;20: 103119.
17.Shedlack K, Lee G, Sakuma Met al. Language processing and memory in ill and well siblings from multiplex families affected with schizophrenia. Schizophr Res 1997;25: 4352.
18.Harris JG, Adler LE, Young DAet al. Neuropsychological dysfunction in parents of schizophrenics. Schizophr Res 1996;20: 253260.
19.Laurent A, Saoud M, Bougerol Tet al. Attentional deficits in patients with schizophrenia and in their non-psychotic first-degree relatives. Psychiatry Res 1999;89: 147159.
20.Wechsler D. Wechsler Memory Scale, 3rd edn. San Antonio, TX: The Psychological Corporation, 1997.
21.Wing JK, Babor T, Brugha Tet al. Schedules for clinical assessment in neuropsychiatry. Arch General Psychiatry 1990;47: 589593.
22.World Health Organization. The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. Geneva: WHO, 1993.
23.American Psychiatric Association CoNaS. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Washington, DC: American Psychiatric Association, 1994.
24.Nelson HE & Willison JR. The Revised National Adult Reading Test-Test Manual. Windsor: NFER- Nelson, 1991.
25.Michie PT, Kent A, Stienstra Ret al. Phenotypic markers as risk factors in schizophrenia: neurocognitive functions. Aust NZ J Psychiatry 2000;34: S74S85.
26.Gold JM, Carpenter C, Randolph C, Goldberg TE, Weinberger DR. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch Gen Psychiatry 1997;54: 159165.
27.Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry 1992;49: 975982.
28.Hartman M, Steketee MC, Silva S, Lanning K, McCann H. Working memory and schizophrenia: evidence for slowed encoding. Schizoph Res 2002;59: 99113.
29.Kremen WS, Faraone SV, Seidman LJ, Pepple JR, Tsuang MT. Neuropsychological risk indicators for schizophrenia: a preliminary study of female relatives of schizophrenic and bipolar probands. Psychiatry Res 1998;79: 227240.
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Acta Neuropsychiatrica
  • ISSN: 0924-2708
  • EISSN: 1601-5215
  • URL: /core/journals/acta-neuropsychiatrica
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