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Frontal cortex reactivity differentiates between schizophrenic subtypes: auditory ERP-evidence

Published online by Cambridge University Press:  15 April 2016

B. Van Sweden ,
M.G. Van Erp ,
F. Mesotten  and
M. Maes
B. Van Sweden*
Affiliation:
Dept. Clin. Neurophysiol, Medical Centre St-Jozef Bilzen, Belgium Dept. Psychiatry and Neuropsychology, Maastricht University, The Netherlands
M.G. Van Erp
Affiliation:
Dept. Clin. Neurophysiol, Medical Centre St-Jozef Bilzen, Belgium
F. Mesotten
Affiliation:
Psychiatry, Medical Centre St-Jozef Bilzen, Belgium
M. Maes
Affiliation:
Dept. Psychiatry and Neuropsychology, Maastricht University, The Netherlands
*
E. Van Havermaetestraat 38 9030 Ghent -, BelgiumFax.:, 00-32-89 50 90 79, Tel.: 00-32-89 50 91 11
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Summary

Objectives: To extend the hypothesis that late auditory EP shifts represent pathophysiologcial markers in schizophrenia. Methods: Early negative (±100 μs) and late positive (>300 ms) auditory oddball and CNV responses are topographically compared in 3 medicated schizophrenic subtypes.

Results: Only late cortical responses differentiate between paranoid, residual and disorganised schizophrenia. Core features of the deficit residual state encompass low-voltage N2P3 responses and missing central initial CNV components. Both paranoid and disorganised schizophrenics show a distinctive reactivity of the frontal cortex. Paranoid schizophrenia is characterized by an extensive frontal spread of the task-related P3 response. Disorganised schizophrenia shows a specifically increased frontal CNV component indicating a nonspecific arousal reaction.

Conclusion: Combinations of late auditory EP-patterns fairly fit with the cognitive/behavioral status observed in schizophrenia spectrum disorders.

Keywords

auditory oddballschizophrenic subtypesspecificitytopographyN1P2/N2P3iCNV/tCNVPINV responses
Type
Articles
Information
Acta Neuropsychiatrica , Volume 13 , Issue 3 , September 2001 , pp. 61 - 67
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2001

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