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Immune disturbances in severely depressed patients: relationship with Cortisol secretion

Published online by Cambridge University Press:  18 September 2015

M. Maes ,
E. Bosmans ,
E. Suy ,
B. Minner  and
J. Rausn
M. Maes
Affiliation:
Van het Psychiatrisch Centrum. Munsterbilzen
E. Bosmans
Affiliation:
het Dr. L. Willems Instituut. Diepenbeek
E. Suy
Affiliation:
Van het Psychiatrisch Centrum. Munsterbilzen
B. Minner
Affiliation:
Van het Psychiatrisch Centrum. Munsterbilzen
J. Rausn
Affiliation:
het Dr. L. Willems Instituut. Diepenbeek
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Abstract

The mitogen induced lymphocyte responses were measured in 33 depressed patients categorized according to the DSM-III into minor (300.40, 309.00), simple major (296.X2) and major depression with melancholia and/or psychotic features (296.X3, 296.X4). Three distinct mitogens were used, i.e. phytohemaglutinin (PHA), pokeweed mitogen (PWM) and concanavalin A (CON A). We found that major depressives with associated features showed significantly lower mitogen induced lymphocyte responses to PHA and PWM as compared to all other depressed patients. The severity of illness was significantly inversely related to the lymphocyte responses to PHA. Cortisol nonsuppressors exhibited significantly lower PHA and PWM induced lymphocyte responses as compared with suppressors. There were significant and negative correlations between the postdexamethasone Cortisol values and the PHA and PWM stimulated lymphocyte responses.

Keywords

depressionmitogen-induced-lymphocyte responsesDSTdepressieDSTlymfocyten transforma-tie test
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 2 , Issue 1 , March 1990 , pp. 3 - 7
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1990

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References

Literatuur

1.Calabrese, JR, Kling, MA, Gold, PW. Alterations in immunocompetence during stress, bereavement, and depression: focus on neuroendocrine regulation. Am J Psychiatry 1987; 144:1123–34.Google ScholarPubMed
2.Schleifer, SJ, Keller, SE, Meyerson, AT, Raskin, MJ, Davis, KL, Stein, M. Lymphocyte function in major depressive disorder. Arch Gen Psychiatry 1984;41:484–6.CrossRefGoogle ScholarPubMed
3.Schleifer, SJ, Keller, SE, Siris, SG, Davis, KL, Stein, M. Depression and immunity: lymphocyte function in ambulatory depressed patients, hospitalized schizophrenic patients, and patients hospitalized for herniorrhaphy. Arch Gen Psychiatry 1985; 42:129–33.CrossRefGoogle ScholarPubMed
4.Kronfol, Z, House, D. Depression, hypothalamic-pituitary-adrenocortical activity and lymphocyte function. Psychopharmacol Bull 1985; 21:476–8.Google ScholarPubMed
5.Kronfol, Z, House, JD, Silva, J, Greden, J, Carroll, BJ. Depression, urinary free Cortisol excretion and lymphocyte function. Brit J Psychiatry 1986; 148:70–3.CrossRefGoogle ScholarPubMed
6.Maes, M, Bosnians, E, Suy, E, Minner, B, Raus, J. The impaired mitogen lymphocyte stimulation in severely depressed patients: a complex interface between HPA — axis hyperfunction, noradrenergic activity and the ageing process. Brit J Psychiatry 1989; 155:793–8.CrossRefGoogle ScholarPubMed
7.Albrecht, J, Helderman, JH, Schlesser, MA, Rush, AJ. A controlled study of cellular immune function in affective disorders before and during somatic therapy. Psychiatr Res 1985; 15:185–93.CrossRefGoogle ScholarPubMed
8.Stein, M. A reconsideration of specificity in psychosomatic medicine: from olfaction to the lymphocyte. Psychosom Med 1986;48:3–22.CrossRefGoogle ScholarPubMed
9.Feinberg, M, Carroll, BJ. Biological markers for endogeneous depression: effects of age, severity of illness, weight loss and polarity. Arch Gen Psychiatry 1984; 41:1080–5.CrossRefGoogle ScholarPubMed
10.Maes, M, De Ruyter, M, Hobin, P, Suy, E. The dexamethasone suppression test, the Hamilton Depression Rating Scale and the DSM-III depressive categories. J. Affect Disord 1986; 10:207–14.CrossRefGoogle Scholar
11.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 3rd ed. Washington, DC: APA, 1980.Google Scholar
12.Spitzer, RL, Williams, JBW, Gibbons, M: Structured Clinical Interview for DSM-III Patient Version. Biometrics Research Department, New York State Psychiatric Institute, New York, 1985.Google Scholar
13.Hamilton, M: A rating scale for depression. J Neurol Neurosurg Psychiat 1960;23:56–61.CrossRefGoogle ScholarPubMed
14.Keller, SE, Schleifer, SJ, Sherman, J, et al.Comparison of a simplified whole blood and isolated lymphocyte stimulation technique. Immunol Comm 1981; 10:417–31.CrossRefGoogle ScholarPubMed
15.Levi, F, Canon, C, Blum, J-P, Reinberg, A, Mathé, G. Large amplitude circadian rhythm in helper: suppressor ratio of peripheral blood lymphocytes. Lancet 1983; 2:462–3.CrossRefGoogle ScholarPubMed
16.Ritchie, AWS, Oswald, I, Micklem, HS, Boyd, JE, Elton, RA, Jazwinska, E, James, K. Circadian variation of lymphocyte subpopulations: a study with monoclonal antibodies. Brit med J 1983; 286:1773–5.CrossRefGoogle ScholarPubMed
17.Bistrian, BR, Blackburn, GL, Schrimshaw, NSet al.Cellular immunity in semi-starved states in hospitalized adults. Am J Clin Nutrii 1975; 28:1148–55.CrossRefGoogle Scholar
18.Oppenheim, J, Dougherty, S, Chan, S. Use of lymphocyte transformation to assess clinical disorders, in Laboratory Diagnosis of Immunological Disorders. Edited by Vyas, D, Stites, D, Brecher, G. New York NY, Grune and Stratton, 1975.Google Scholar
19.Maes, M, Bosmans, E, Suy, E, Minner, B, Raus, J. Immune cell parameters in severely depressed patients: negative findings. J Affect Disord 1989; 16:121–8.CrossRefGoogle Scholar