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Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression

Published online by Cambridge University Press:  16 July 2018

Bruna Panizzutti ,
Chiara Bortolasci ,
Kyoko Hasebe ,
Srisaiyini Kidnapillai ,
Laura Gray ,
Ken Walder ,
Michael Berk ,
Mohammadreza Mohebbi ,
Seetal Dodd  and
Clarissa Gama
...Show all authors
Bruna Panizzutti
Affiliation:
Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
Chiara Bortolasci
Affiliation:
Graduation Program in Health Sciences, State University of Londrina (UEL), Londrina, Brazil Deakin University, School of Medicine, Centre for Molecular and Medical Research, Geelong, Australia
Kyoko Hasebe
Affiliation:
Deakin University, School of Medicine, Centre for Molecular and Medical Research, Geelong, Australia
Srisaiyini Kidnapillai
Affiliation:
Deakin University, School of Medicine, Centre for Molecular and Medical Research, Geelong, Australia
Laura Gray
Affiliation:
Deakin University, School of Medicine, Centre for Molecular and Medical Research, Geelong, Australia The Florey Institute of Neuroscience and Mental Health, Parkville, Australia
Ken Walder
Affiliation:
Deakin University, School of Medicine, Centre for Molecular and Medical Research, Geelong, Australia
Michael Berk
Affiliation:
Deakin University, School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Geelong, Australia Department of Psychiatry, The University of Melbourne, Parkville, Australia The Florey Institute of Neuroscience and Mental Health, Parkville, Australia Orygen Centre for Youth Mental Health, University of Melbourne, Parkville, Australia
Mohammadreza Mohebbi
Affiliation:
Deakin University, Biostatistics Unit, Faculty of Health, Geelong, Australia
Seetal Dodd
Affiliation:
Deakin University, School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Geelong, Australia Department of Psychiatry, The University of Melbourne, Parkville, Australia Orygen Centre for Youth Mental Health, University of Melbourne, Parkville, Australia
Clarissa Gama
Affiliation:
Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
Pedro V. Magalhães
Affiliation:
Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
Susan M. Cotton
Affiliation:
Orygen Centre for Youth Mental Health, University of Melbourne, Parkville, Australia The National Centre of Excellence in Youth Mental Health, Parkville, Australia
Flávio Kapczinski
Affiliation:
Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
Ashley I. Bush
Affiliation:
Department of Psychiatry, The University of Melbourne, Parkville, Australia The Florey Institute of Neuroscience and Mental Health, Parkville, Australia
Gin S. Malhi
Affiliation:
Academic Department of Psychiatry, Northern Sydney Local Health District, St Leonards, NSW, Australia Sydney Medical School Northern, University of Sydney, NSW, Australia CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia
Olivia M. Dean*
Affiliation:
Deakin University, School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Geelong, Australia Department of Psychiatry, The University of Melbourne, Parkville, Australia The Florey Institute of Neuroscience and Mental Health, Parkville, Australia
*
Author for correspondence: Dr. Olivia Dean, IMPACT SRC, School of Medicine, Deakin University, Kitchener House, P.O. Box 281, Geelong, VIC 3220, Australia. Tel: +61 3 4215 3300; Fax: 61 3 4215 3491; E-mail: oliviad@barwonhealth.org.au.
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Abstract

Objective

This study aimed to explore effects of adjunctive treatment with N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression.

Methods

This is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-label and maintenance phases of the clinical trial to determine changes in interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following adjunctive NAC treatment, and to explore mediation and moderator effects of the listed markers.

Results

Levels of brain-derived neurotrophic factor (BDNF), tumour necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukins (IL) -6, 8, or 10 were not significantly changed during the course of the trial or specifically in the open-label and maintenance phases. There were no mediation or moderation effects of the biological factors on the clinical parameters.

Conclusion

The results suggest that these particular biological parameters may not be directly involved in the therapeutic mechanism of action of adjunctive NAC in bipolar depression.

Keywords

biomarkersbipolar disorderclinical trialdepressionN-acetyl cysteine
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 30 , Issue 6 , December 2018 , pp. 334 - 341
Copyright
© Scandinavian College of Neuropsychopharmacology 2018 

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