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Recurring déjà vu associated with 5-hydroxytryptophan

  • Seema Kalra (a1), Andrew Chancellor (a2) and Adam Zeman (a3)
Abstract
Background:

Déjà vu occurs both in normal experience and as a neuropsychiatric symptom. Its pathogenesis is partially understood. We describe an iatrogenic case with implications for the neuropharmacological basis of déjà vu.

Case presentation:

A 42-year-old woman received 5-hydroxytryptophan, in combination with carbidopa, as treatment for palatal tremor, on two occasions, separated by 1 week. On each occasion, she experienced intense, protracted déjà vu, lasting for several hours. We discuss her case in relation to the neuroanatomical and neuropharmacological basis of déjà vu.

Conclusion:

The serotonergic system is involved in the genesis of déjà vu.

Copyright
Corresponding author
Professor Adam Zeman, Peninsula Medical School, Exeter EX2 4UD, UK. Tel: 01392-208581/208583; Fax: 01392-662929; E-mail: adam.zeman@pms.ac.uk
References
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Acta Neuropsychiatrica
  • ISSN: 0924-2708
  • EISSN: 1601-5215
  • URL: /core/journals/acta-neuropsychiatrica
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