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The relationship between potency of oxidative stress and severity of depression

Published online by Cambridge University Press:  24 June 2014

Medaim Yanik ,
Ozcan Erel  and
Mahmut Kati
Medaim Yanik*
Affiliation:
Department of Biochemistry, Research Hospital, Harran University, Sanliurfa, Turkey
Ozcan Erel
Affiliation:
Department of Biochemistry, Research Hospital, Harran University, Sanliurfa, Turkey
Mahmut Kati
Affiliation:
Department of Biochemistry, Research Hospital, Harran University, Sanliurfa, Turkey
*
Medaim Yanik, MD, Associate Professor, Harran University, Medical Faculty, Research Hospital, Department of Psychiatry, Sanliurfa TR-63100, Turkey. Tel: (90) 4143127976; Fax: (90) 4143151181; E-mail: medaim@hotmail.com
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Abstract

Background:

Oxidative stress is one of the suggested mechanisms in major depression.

Objective:

To determine the oxidative and antioxidative status of plasma of patients with major depression and to investigate whether there is a relationship between the potency of oxidative stress and the severity of depression.

Methods:

To determine the antioxidative status of plasma, total and individual antioxidant levels which are total antioxidant potential (TAOP), total protein, albumin, uric acid, vitamin C and total bilirubin were measured. To determine the oxidative status, total peroxide level of plasma was measured in patients with drug-free depressive patients and compared with those of controls. Per cent ratio of total peroxide to TAOP was evaluated as oxidative stress index (OSI).

Results:

Plasma TAOP and individual antioxidant levels were found to be lower in patients with depression than those of controls. On the contrary, the patients had high total plasma peroxide levels. OSI values of the patients were significantly higher than those of controls (P = 0.002), and a significant positive correlation between Hamilton Depression Rating Scale (HDRS) and OSI values was found (r = 0.54, P = 0.01).

Conclusions:

The patients with major depression are exposed to oxidative stress, and OSI may be useful to reflect the severity of the disease.

Keywords

antioxidantdepressionHamilton Depression Rating Scaleoxidantoxidative stresstotal antioxidant
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 16 , Issue 4 , August 2004 , pp. 200 - 203
Copyright
Copyright © 2004 Blackwell Munksgaard

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