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Serum levels of folate, vitamin B6, and vitamin B12 are associated with cognitive impairments in depression patients

Published online by Cambridge University Press:  29 August 2023

Lei Zhao ,
Lili Guan ,
Jinyan Sun  and
Xiaoming Li Open the ORCID record for Xiaoming Li [Opens in a new window]
Lei Zhao
Affiliation:
Pharmacy Department, Qingdao Mental Health Center, Qingdao, Shandong, China
Lili Guan
Affiliation:
Pharmacy Department, Qingdao Mental Health Center, Qingdao, Shandong, China
Jinyan Sun
Affiliation:
Pharmacy Department, Qingdao Mental Health Center, Qingdao, Shandong, China
Xiaoming Li*
Affiliation:
Pharmacy Department, Qingdao Mental Health Center, Qingdao, Shandong, China
*
Corresponding author: Xiaoming Li; Email: xiaoming875174839@126.com
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Abstract

Introduction:

Depression is a common mental disorder that endangers physical and mental health. In our study, we aimed to explore whether B vitamins are associated with depression and cognitive dysfunction.

Methods:

We enrolled a total of 220 patients with depression and selected 100 controls at the same time. We determined depression and cognitive impairment by assessments. We recorded the basic parameters of the participants and collected blood samples. In addition, we measured serum levels of B vitamins and brain-derived neurotrophic factor (BDNF).

Results:

We found significant differences in the duration of depression, education, and Hamilton Depression Rating Scale scores between the D-NCI and D-CI groups. We also identified the independent risk factors for patients with depression and cognitive dysfunction. Compared with the healthy controls, serum folate, vitamin B6, and vitamin B12 positively correlated with cognitive dysfunction. The patients with depression and cognitive dysfunction had the lowest levels of B vitamins compared with the other two groups. Our results also showed that the levels of serum folate, vitamin B6, and vitamin B12 in the patients with depression had a positive correlation with each other.

Conclusion:

Our results indicate that vitamin B is associated with depression and cognitive dysfunction and is positively associated with cognitive dysfunction.

Keywords

Vitamin B6vitamin B12folatedepressioncognitive impairment
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 36 , Issue 1 , February 2024 , pp. 44 - 50
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology

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