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Treatment of gambling disorder patients with comorbid depression

  • Jakob Linnet (a1) (a2), Monique Jeppsen Mensink (a1), Johanne de Neergaard Bonde (a1) (a3) and Michael Winterdahl (a3)

This study was conducted to investigate and clinically assess comorbid depression and its relevance in individuals suffering from gambling disorders. The DSM-V defines the condition of gambling disorder as a persistent and recurrent problematic gambling behaviour leading to clinically significant impairment or distress.


A total of 61 subjects with gambling disorders were assessed using the Structured Clinical Interview for the DSM-IV (SCID-I), the South Oaks Gambling Screen (SOGS) and the Major Depression inventory (MDI).


Two-way analysis of variance showed highly significant treatment outcomes associated with reductions in SOGS, F(1,60)=84.79, p<0.0001, MDI, F(1,60)=38.13, p<0.0001, craving, F(1,60)=29.59, p<0.0001, and gambling control, 47.65, p<0.0001. There was also a highly significant outcome associated with comorbidity in MDI, F(1,60)=9.17, p<0.0001. Finally, there was a significant interaction effect between treatment outcome and comorbidity, F(1,60)=3.90, p<0.005, suggesting that both treatment and comorbidity contributed to reductions in depressive symptoms.


These results suggest and highlights the importance and benefits of integrated treatment of gambling disorders and its comorbidity, but also stresses the importance of adequate screening and detection of these two variables.

Corresponding author
*Jakob Linnet, Research Clinic on Gambling Disorders, Aarhus University Hospital, Nørrebrogade 44, Building 4A, DK-8000 Aarhus C, Denmark. Tel: (+45) 78 46 16 98; E-mail:
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1. SR Chamberlain , K Derbyshire , E Leppink , JE Grant . Impact of ADHD symptoms on clinical and cognitive aspects of problem gambling. Compr Psychiatry 2015;57:5157.

3. E Becona , M Del Carmen Lorenzo , MJ Fuentes . Pathological gambling and depression. Psychol Rep 1996;78:635640.

5. RG Smart , J Ferris . Alcohol, drugs and gambling in the Ontario adult population, 1994. Can J Psychiatry 1996;41:3645.

6. DN Crockford , N el-Guebaly . Psychiatric comorbidity in pathological gambling: a critical review. Can J Psychiatry 1998;43:4350.

7. C Linardatou , A Parios , L Varvogli , G Chrousos , C Darviri . An 8-week stress management program in pathological gamblers: a pilot randomized controlled trial. J Psychiatr Res 2014;56:137143.

10. JC Marceaux , CL Melville . Twelve-step facilitated versus mapping-enhanced cognitive-behavioral therapy for pathological gambling: a controlled study. J Gambl Stud 2011;27:171190.

11. DF Wong , CL Chung , J Wu , J Tang , P Lau , JP Wan . A preliminary study of an integrated and culturally attuned cognitive behavioral group treatment for Chinese problem gamblers in Hong Kong. J Gambl Stud 2015;31:10151027.

12. JE Grant , CB Donahue , BL Odlaug , SW Kim , MJ Miller , NM Petry . Imaginal desensitisation plus motivational interviewing for pathological gambling: randomised controlled trial. Br J Psychiatry 2009;195:266267.

14. R Ladouceur , S Lachance , PM Fournier . Is control a viable goal in the treatment of pathological gambling? Behav Res Ther 2009;47:189197.

19. H Lesieur , SB Blume . Revising the South Oaks gambling screen in different settings. J Gambl Stud 1993;9:213223.

22. P Bech , N-A Rasmussen , L Olsen , V Noerholm , W Abildgaard . The sensitivity and specificity of the Major Depression Inventory, using the present state examination as the index of diagnostic validity. J Affect Disord 2001;66:159164.

23. LR Olsen , DV Jensen , V Noerholm , K Martiny , P Bech . The internal and external validity of the Major Depression Inventory in measuring severity of depressive states. Psychol Med 2003;33:351356.

25. R Ladouceur , C Sylvain , C Boutin , S Lachance , C Doucet , J Leblond , C Jacques . Cognitive treatment of pathological gambling. J Nerv Ment Dis 2001;189:774780.

28. R Stinchfield , J McCready , NE Turner et al. Reliability, validity, and classification accuracy of the DSM-5 diagnostic criteria for gambling disorder and comparison to DSM-IV. J Gambl Stud 2015;32:905922.

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Acta Neuropsychiatrica
  • ISSN: 0924-2708
  • EISSN: 1601-5215
  • URL: /core/journals/acta-neuropsychiatrica
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