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Val66Met polymorphism and serum brain-derived neurotrophic factor concentration in depressed patients

Published online by Cambridge University Press:  24 June 2014

Xiao-bin Zhang ,
Xin Wang ,
Wei-wei Sha ,
Hong-hui Zhou  and
Yu-mei Zhang
Xiao-bin Zhang*
Affiliation:
Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, P.R. China
Xin Wang
Affiliation:
Department of Tradition Chinese and Western medicine, Nanjing University of Chinese Medicine, Nanjing 210009, P.R. China
Wei-wei Sha
Affiliation:
Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, P.R. China
Hong-hui Zhou
Affiliation:
Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, P.R. China
Yu-mei Zhang
Affiliation:
Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, P.R. China
*
Professor Xiao-bin Zhang, Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, P.R. China. Tel: +86 514 87207382; Fax: +86 514 87207251; E-mail: zhangxiaobim@163.com
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Extract

Zhang X, Wang X, Sha W, Zhou H, Zhang Y. Val66Met polymorphism and serum brain-derived neurotrophic factor concentration in depressed patients.

Objective: Accumulating evidence has suggested a pathophysiological role for brain-derived neurotrophic factor (BDNF) in major depressive disorder (MDD). The present study evaluated serum levels of BDNF and explored whether Val66Met BDNF gene polymorphism is correlated with changes in circulating BDNF levels in patients with MDD and control subjects.

Methods: Subjects were 76 patients with MDD and 50 controls. Diagnosis of MDD was determined by the use of a structured clinical interview according to Diagnostic and Statistical Manual of Mental Disorder-IV (DSM-IV) criteria. The concentrations of BDNF were measured by using the enzyme-linked immunosorbent assay. The Val66Met BDNF gene polymorphism was examined by the polymerase chain reaction technique.

Results: Serum BDNF was significantly lower in MDD patients than in normal control subjects (p < 0.001). There were no significant differences either in allele or genotype in the Val66Met polymorphism between the MDD and control groups. Moreover, genotype did not significantly correlate with the BDNF serum levels in the MDD or control groups.

Conclusions: Our study suggests that there is a decrease in serum BDNF levels in untreated MDD patients. However, serum BDNF levels were not associated with the Val66Met polymorphism.

Keywords

brain-derived neurotrophic factorgenotypemajor depressive disorderserum
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 23 , Issue 5 , October 2011 , pp. 229 - 234
Copyright
Copyright © Cambridge University Press 2011

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References

1 Huang, EJ, Reichardt, LF. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001;24:677–736. CrossRefGoogle Scholar
2 Brunoni, AR, Lopes, M, Fregni, F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 2008;11:1169–1180. CrossRefGoogle ScholarPubMed
3 Russo-Neustadt, A, Ha, T, Ramirez, R, Kesslak, JP. Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model. Behav Brain Res 2001;120:87–95. CrossRefGoogle ScholarPubMed
4 Smith, MA, Makino, S, Kvetnansky, R, Post, RM. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 1995;15:1768–1777. Google ScholarPubMed
5 Schmidt, HD, Duman, RS. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol 2007;18:391–418. CrossRefGoogle ScholarPubMed
6 Koolschijn, PC, van Haren, NE, Lensvelt-Mulders, GJ, Hulshoff Pol, HE, Kahn, RS. Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studies. Hum Brain Mapp 2009;30:3719–3735. CrossRefGoogle ScholarPubMed
7 Siuciak, JA, Lewis, DR, Wiegand, SJ, Lindsay, RM. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 1997;56:131–137. CrossRefGoogle ScholarPubMed
8 Altar, CA, Whitehead, RE, Chen, R, Wörtwein, G, Madsen, TM. Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biol Psychiatry 2003;54:703–709. CrossRefGoogle ScholarPubMed
9 Chen, B, Dowlatshahi, D, MacQueen, GM, Wang, JF, Young, LT. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 2001;50:60–265. CrossRefGoogle ScholarPubMed
10 Dwivedi, Y, Rizavi, HS, Conley, RR, Roberts, RC, Tamminga, CA, Pandey, GN. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 2003;60:804–815. CrossRefGoogle ScholarPubMed
11 Karege, F, Bondolfi, G, Gervasoni, N, Schwald, M, Aubry, JM, Bertschy, G. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry 2005;57:1068–1072. CrossRefGoogle ScholarPubMed
12 Gonul, AS, Akdeniz, F, Taneli, F, Donat, O, Eker, C, Vahip, S. Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 2005;255:381–386. CrossRefGoogle ScholarPubMed
13 Sen, S, Duman, R, Sanacora, G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analysis and implications. Biol Psychiatry 2008;64:527–532. CrossRefGoogle ScholarPubMed
14 Rybakowski, JK. BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia. Pharmacogenomics 2008;9:1589–1593. CrossRefGoogle ScholarPubMed
15 Schumacher, J, Jamra, RA, Becker, T et al. Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry 2005;58:307–314. CrossRefGoogle ScholarPubMed
16 Lang, UE, Hellweg, R, Sander, T, Gallinat, J. The Met allele of the BDNF Val66Met polymorphism is associated with increased BDNF serum concentrations. Mol Psychiatry 2009;14:120–122. CrossRefGoogle ScholarPubMed
17 Ozan, E, Okur, H, Eker, C, Eker, OD, Gönül, AS, Akarsu, N. The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels. Brain Res Bull 2010;81:61–65. CrossRefGoogle ScholarPubMed
18 Jiang, H, Wang, R, Liu, Y, Zhang, Y, Chen, ZY. BDNF Val66Met polymorphism is associated with unstable angina. Clin Chim Acta 2009;400:3–7. CrossRefGoogle ScholarPubMed
19 Trajkovska, V, Marcussen, AB, Vinberg, M, Hartvig, P, Aznar, S, Knudsen, GM. Measurements of brain-derived neurotrophic factor: methodological aspects and demographical data. Brain Res Bull 2007;73:143–149. CrossRefGoogle ScholarPubMed
20 Tramontina, J, Frey, BN, Andreazza, AC, Zandona, M, Santin, A, Kapczinski, F. Val66met polymorphism and serum brain-derived neurotrophic factor levels in bipolar disorder. Mol Psychiatry 2007;12:230–231. CrossRefGoogle ScholarPubMed
21 American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th edn. Washington, DC: American Psychiatric Association, 1994.Google Scholar
22 First, MB, Spitzer, RL, Gibbon, M, Williams, JB. Structured clinical interview for DSM-IV (SCID-I). New York: Biomedics Research Department, 1998.Google Scholar
23 Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62. CrossRefGoogle ScholarPubMed
24 Bagby, RM, Ryder, AG, Schuller, DR, MarshaIl, MB. The Hamilton Depression Rating Scale: Has the Gold Standard become a lead weight? Am J Psychiatry 2004;161: 2163–2177. CrossRefGoogle ScholarPubMed
25 Maier, W, Philipp, M. Improving the assessment of severity of depressive states: a reduction of the Hamilton Depression Scale. Pharmacopsychiatry 1985;18:114–115. CrossRefGoogle Scholar
26 Lee, BH, Kim, YK. Reduced platelet BDNF level in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:849–853. CrossRefGoogle ScholarPubMed
27 Bocchio-Chiavetto, L, Bagnardi, V, Zanardini, R et al. Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. World J Biol Psychiatry 2010;11:763–773. CrossRefGoogle ScholarPubMed
28 Shimizu, E, Hashimoto, K, Okamura, N et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003;54:70–75. CrossRefGoogle ScholarPubMed
29 Lee, BH, Kim, H, Park, SH, Kim, YK. Decreased plasma BDNF level in depressive patients. J Affect Disord 2007;101:239–244. CrossRefGoogle ScholarPubMed
30 Bus, BA, Molendijk, ML, Penninx, BJ et al. Determinants of serum brain-derived neurotrophic factor. Psychoneuroendocrinology 2011;36:228–239. CrossRefGoogle ScholarPubMed
31 Huang, TL, Lee, CT, Liu, YL. Serum brain-derived neurotrophic factor levels in patients with major depression: effects of antidepressants. J Psychiatr Res 2008;42:521–525. CrossRefGoogle ScholarPubMed
32 Hong, CJ, Huo, SJ, Yen, FC, Tung, CL, Pan, GM, Tsai, SJ. Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 2003;48:186–189. CrossRefGoogle ScholarPubMed
33 Tsai, SJ, Cheng, CY, Yu, YW, Chen, TJ, Hong, CJ. Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response. Am J Med Genet B Neuropsychiatr Genet 2003;123B:19–22. CrossRefGoogle ScholarPubMed
34 Hwang, JP, Tsai, SJ, Hong, CJ, Yang, CH, Lirng, JF, Yang, YM. The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol Aging 2006;27:1834–1837. CrossRefGoogle ScholarPubMed
35 Zou, YF, Ye, DQ, Feng, XL, Su, H, Pan, FM, Liao, FF. Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder. Eur Neuropsychopharmacol 2010;20: 535–544. CrossRefGoogle ScholarPubMed
36 Kato, M, Serretti, A. Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatry 2010;15:473–500. CrossRefGoogle ScholarPubMed
37 Domschke, K, Lawford, B, Laje, G et al. Brain-derived neurotrophic factor (BDNF) gene: no major impact on antidepressant treatment response. Int J Neuropsychopharmacol 2010;13:93–101. CrossRefGoogle ScholarPubMed
38 Verhagen, M, van der Meij, A, van Deurzen, PA, Janzing, JG, Arias-Vásquez, A, Buitelaar, JK, Franke, B. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol Psychiatry 2010;15:260–271. CrossRefGoogle ScholarPubMed
39 Chen, ZY, Patel, PD, Sant, G, Meng, CX, Teng, KK, Hempstead, BL, Lee, FS. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 2004;24:4401–4411. CrossRefGoogle ScholarPubMed
40 Egan, MF, Kojima, M, Callicott, JH et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003;112:257–269. CrossRefGoogle ScholarPubMed
41 Chen, ZY, Jing, D, Bath, KG et al. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 2006;314:140–143. CrossRefGoogle ScholarPubMed
42 Terracciano, A, Martin, B, Ansari, D et al. Plasma BDNF concentration, Val66Met genetic variant and depression-related personality traits. Genes Brain Behav 2010;9: 512–518. CrossRefGoogle ScholarPubMed