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Visually evoked potentials, NMDA receptors and the magnocellular system in schizophrenia

  • Bernt C. Skottun (a1) and John R. Skoyles (a2) (a3)

Background: It has been claimed that schizophrenia can be linked to the magnocellular system by way of N-methyl-d-aspartate (NMDA) receptors. The present report examines this claim.

Methods: A review is made of relevant research literature.

Results: The NMDA studies that have been referenced to connect visual deficits in schizophrenia to the magnocellular system are based on the cat, a species whose visual system is fundamentally different from that of primates. The cat visual system cannot easily be divided into magno- and a parvocellular portions.

Conclusions: Owing to the substantial differences between the visual systems of cats and primates, it is difficult to link sensory abnormalities in schizophrenia specifically to the magnocellular system based on data from the cat.

Corresponding author
John R. Skoyles, Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London NW1 2HE, UK. Tel/Fax: +0207 6794325; E-mail:
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Acta Neuropsychiatrica
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  • EISSN: 1601-5215
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