Skip to main content Accessibility help
×
×
Home

Combining antidepressants: understanding drug interactions is the sine qua non

  • Ken Gillman (a1)
  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Combining antidepressants: understanding drug interactions is the sine qua non
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Combining antidepressants: understanding drug interactions is the sine qua non
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Combining antidepressants: understanding drug interactions is the sine qua non
      Available formats
      ×

Abstract

Copyright

References

Hide All
Albers, LJ, Reist, C, Helmeste, D et al (1996) Paroxetine shifts imipramine metabolism. Psychiatry Research; 59: 189–96.
Bakish, D, Hooper, CL, West, DL et al (1995) Moclobemide and specific serotonin reuptake inhibitor combination treatment of resistant anxiety and depressive disorders. Human Psychopharmacology; 10: 105–9.
Blier, P, Saint-Andre, E, Hebert, C et al (2007) Effects of different doses of venlafaxine on serotonin and norepinephrine reuptake in healthy volunteers. International Journal of Neuropsychopharmacology; 10: 4150.
Brosen, K (2004) Some aspects of genetic polymorphism in the biotransformation of antidepressants. Therapie; 59: 512.
Debonnel, G, Saint-André, É, Hébert, C et al (2007) Differential physiological effects of a low dose and high doses of venlafaxine in major depression. International Journal of Neuropsychopharmacology; 10: 5161.
Dodd, S, Horgan, D, Malhi, GS et al (2005) To combine or not to combine? A literature review of antidepressant combination therapy. Journal of Affective Disorders; 89: 111.
Draper, AJ, Madan, A, Parkinson, A (1997) Inhibition of coumarin 7-hydroxylase activity in human liver microsomes. Archives of Biochemistry and Biophysics; 341: 4761.
Ebert, D, Albert, R, May, A et al (1995) Combined SSRI-RIMA treatment in refractory depression. Safety data and efficacy. Psychopharmacology; 119: 342–4.
Flockhart, DA (2009) Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (http://medicine.iupui.edu/clinpharm/ddis/table.asp).
Gillman, PK (2004) Moclobemide and the risk of serotonin toxicity (or serotonin syndrome). Central Nervous System Drug Reviews; 10: 83–5.
Gillman, PK (2006) A review of serotonin toxicity data: implications for the mechanisms of antidepressant drug action. Biological Psychiatry; 59: 1046–51.
Gillman, PK (2007) Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. British Journal of Pharmacology; 151: 737–48 [Free full text].
Hawley, CJ, Quick, SJ, Ratnam, S et al (1996) Safety and tolerability of combined treatment with moclobemide and SSRIs – a systematic study of 50 patients. International Clinical Psychopharmacology; 11: 187–91.
Holt, A, Berry, MD, Boulton, AA (2004) On the binding of monoamine oxidase inhibitors to some sites distinct from the MAO active site, and effects thereby elicited. Neurotoxicology; 25: 251–66.
Ingelman-Sundberg, M (2005a) Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics Journal; 5: 613 [Free full text].
Ingelman-Sundberg, M, Rodriguez-Antona, C (2005b) Pharmacogenetics of drug-metabolizing enzymes: implications for a safer and more effective drug therapy. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences; 360: 1563–70.
Joffe, RT, Bakish, D (1994) Combined SSRI-moclobemide treatment of psychiatric illness. Journal of Clinical Psychiatry; 55: 24–5.
Nelson, JC, Mazure, CM, Jatlow, PI et al (2004) Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study. Biological Psychiatry; 55: 296300.
Palaniyappan, L, Insole, L, Ferrier, N (2009) Combining antidepressants: a review of evidence. Advances in Psychiatric Treatment; 15: 90–9.
Preskorn, S, Flockhart, D (2006) 2006 Guide to psychiatric drug interactions. Primary Psychiatry; 13: 3564.
Sim, SC, Ingelman-Sundberg, M (2006) The human cytochrome P450 Allele Nomenclature Committee Web site: submission criteria, procedures, and objectives. Methods in Molecular Biology; 320: 183–91.
Whyte, IM, Dawson, AH, Buckley, NA (2003) Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants. Quarterly Journal of Medicine; 96: 369–74 [Free full text].
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

BJPsych Advances
  • ISSN: 1355-5146
  • EISSN: 1472-1481
  • URL: /core/journals/bjpsych-advances
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Combining antidepressants: understanding drug interactions is the sine qua non

  • Ken Gillman (a1)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *