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Glutamate and psychiatric disorders

  • Eva M. Tsapakis and Michael J. Travis

Most of the excitatory neurotransmission in the central nervous system (CNS) is mediated by the endogenous excitatory amino acids (EAAs) glutamate, aspartate and homocysteine. Most of the endogenous inhibitory neurotransmission is mediated by gamma-aminobutyric acid (GABA). EAAs modulate the firing of almost all neurons in the CNS, as excitatory neurotransmission can result in both neuronal inhibition and excitation. The glutamate system is the best characterised of the EAA systems (Box 1).

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BJPsych Advances
  • ISSN: 1355-5146
  • EISSN: 1472-1481
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Glutamate and psychiatric disorders

  • Eva M. Tsapakis and Michael J. Travis
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