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Management of the renal adverse effects of lithium

  • Sumeet Gupta, Mukesh Kripalani, Udayan Khastgir and Joe Reilly

Lithium is one of the most effective psychotropic drugs we have, but it is underused because of its low therapeutic index, the need for regular blood tests and perceptions about its adverse effects, including renal problems. The last include urinary concentration deficits and diabetes insipidus, chronic kidney disease (including renal failure), nephrotic syndrome, hypercalcaemia, hyperparathyroidism and distal tubular acidosis. This article reviews these adverse effects with special emphasis on their management.

Corresponding author
Dr Sumeet Gupta, Consultant Psychiatrist, West Park Hospital, Edward Pease Way, Darlington DL2 2TS, UK. Email:
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Declaration of Interest

S.G. has received financial support to attend conferences from AstraZeneca and Lundbeck. M.K. has received financial support to attend a conference from Bristol-Myers Squibb and Reckitts.

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Management of the renal adverse effects of lithium

  • Sumeet Gupta, Mukesh Kripalani, Udayan Khastgir and Joe Reilly
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