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New diagnostic concepts in Alzheimer's disease

  • Anna Watkin, Sudip Sikdar, Biswadeep Majumdar and Anna V. Richman

Summary

This article gives an overview of the profile of Alzheimer's disease, its pathophysiology and recent developments in technology that enable better understanding of the mechanism of disease. The diagnostic criteria and role of biomarkers proposed are explained. The new subgroups described are outlined in table form for easy reference. Subtypes of mild cognitive impairment (MCI) are reviewed and the conversion of amnestic MCI to Alzheimer's disease is considered. The implications and change to current clinical practice form the basis of the conclusion of the article.

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Copyright

Corresponding author

Dr Sudip Sikdar, Waterloo Day Hospital, Park Road, Waterloo, Liverpool L22 3XR, UK. Email: Sudip.Sikdar@merseycare.nhs.uk

Footnotes

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Declaration of Interest

None.

Footnotes

References

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Alagiakrishnan, K, Gill, SS, Fagarasanu, A (2012) Genetics and epigenetics of Alzheimer's disease. Postgraduate Medical Journal 88: 522–9.
Albert, MS, DeKosky, ST, Dickson, D et al (2011) The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia 7: 270–9.
Bateman, RJ, Xiong, C, Benzinger, TL et al (2012) Clinical and biomarker changes in dominantly inherited Alzheimer's disease. New England Journal of Medicine 367: 795804.
Doraiswamy, PM (2012) Is the idle mind a Devil's workshop? Biological Psychiatry 71: 765–6.
Duara, R, Loewenstein, DA, Greig, MT et al (2011) Pre-MCI and MCI: neuropsychological, clinical, and imaging features and progression rates. American Journal of Geriatric Psychiatry 19: 951–60.
Dubois, B, Albert, ML (2004) Amnestic MCI or prodromal Alzheimer's disease? Lancet Neurology 3: 246–8.
Dubois, B, Feldman, HH, Jacova, C et al (2010) Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurology 9: 1118–27.
Fagan, AM, Mintun, MA, Mach, RH et al (2006) Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Annals of Neurology 59: 512–9.
Feldman, HH, Jacova, C (2005) Mild cognitive impairment. American Journal of Geriatric Psychiatry 13: 645–55.
Forsberg, A, Engler, H, Almkvist, O et al (2008) PET imaging of amyloid deposition in patients with mild cognitive impairment. Neurobiology of Aging 29: 1456–65.
Ganguli, M, Blacker, D, Blazer, DG et al (2011) Classification of neurocognitive disorders in DSM-5: a work in progress. American Journal of Geriatric Psychiatry 19: 205–10.
Gauthier, S, Reisberg, B, Zaudig, M et al (2006) Mild cognitive impairment. Lancet 367: 1262–70.
Getsios, D, Blume, S, Ishak, KJ et al (2012) An economic evaluation of early assessment for Alzheimer's disease in the United Kingdom. Alzheimer's & Dementia 8: 2230.
Gomar, JJ, Bobes-Bascaran, MT, Conejero-Goldberg, C et al (2011) Utility of combinations of biomarkers, cognitive markers, and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer's disease neuroimaging initiative. Archives of General Psychiatry 68: 961–9.
Heinik, J (2010) V. A. Kral and the origins of benign senescent forgetfulness and mild cognitive impairment. International Psychogeriatrics 22: 395402.
Jack, CR Jr., Dickson, DW, Parisi, JE et al (2002) Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology 58: 750–7.
Jack, CR Jr., Knopman, DS, Jagust, WJ et al (2010) Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurology 9: 119–28.
Jack, CR Jr., Albert, MS, Knopman, DS et al (2011) Introduction to the recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia 7: 257–62.
Larner, AJ, Hancock, P (2012) Does combining cognitive and functional scales facilitate the diagnosis of dementia? International Journal of Geriatric Psychiatry 27: 547–8.
McKhann, G, Drachman, D, Folstein, M et al (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939–44.
McKhann, GM, Knopman, DS, Chertkow, H et al (2011) The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia 7: 263–9.
National Institute for Health and Clinical Excellence (2012) Dementia: Supporting People with Dementia and Their Carers in Health and Social Care (NICE Clinical Guideline 42). NICE.
Petersen, RC, Stevens, JC, Ganguli, M et al (2001) Practice parameter. Early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56: 1133–42.
Plassman, BL, Langa, KM, Fisher, GG et al (2008) Prevalence of cognitive impairment without dementia in the United States. Annals of Internal Medicine 148: 427–34.
Sperling, RA, Aisen, PS, Beckett, LA et al (2011) Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia 7: 280–92.
Stephan, BC, Matthews, FE, Khaw, KT et al (2009) Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND). Alzheimer's Research & Therapy 1: 4.
Strozyk, D, Blennow, K, White, LR et al (2003) CSF Abeta 42 levels correlate with amyloid neuropathology in a population-based autopsy study. Neurology 60: 652–6.
Valenzuela, MJ, Matthews, FE, Brayne, C et al (2012) Multiple biological pathways link cognitive lifestyle to protection from dementia. Biological Psychiatry 71: 783–91.
Walsh, DM, Selkoe, DJ (2007) A beta oligomers – a decade of discovery. Journal of Neurochemistry 101: 1172–84.
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BJPsych Advances
  • ISSN: 1355-5146
  • EISSN: 1472-1481
  • URL: /core/journals/bjpsych-advances
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New diagnostic concepts in Alzheimer's disease

  • Anna Watkin, Sudip Sikdar, Biswadeep Majumdar and Anna V. Richman
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