Skip to main content Accessibility help
×
Home

Use of atypical antipsychotic drugs in old age psychiatry

  • Walter Pierre Bouman and Gill Pinner

Extract

Antipsychotic drugs are among the most widely prescribed psychotropic medications for elderly people, particularly for the 5–8% of patients who are in institutions. The antipsychotics are indicated for treating psychotic disorders, including schizophrenia, delusional disorder, psychotic symptoms in mood disorders and for a number of organic psychoses.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Use of atypical antipsychotic drugs in old age psychiatry
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Use of atypical antipsychotic drugs in old age psychiatry
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Use of atypical antipsychotic drugs in old age psychiatry
      Available formats
      ×

Copyright

References

Hide All
Avorn, J., Monane, M., Everitt, D. E. et al (1994) Clinical assessment of extrapyramidal signs in nursing home patients given antipsychotic medication. Archives of Internal Medicine, 154, 11131117.
Ballard, C., Bannister, C., Graham, C. et al (1995) Associations of psychotic symptoms in dementia sufferers. British Journal of Psychiatry, 167, 537540.
Beasley, C.M., Tollefson, G. D. & Tran, P. V. (1997) Efficacy of olanzapine: an overview of pivotal clinical trials. Journal of Clinical Psychiatry, 58 (suppl. 10), 712.
Bhana, N. & Spencer, C. M. (2000) Risperidone – a review of its use in the management of the behavioural and psychological symptoms of dementia. Drugs and Aging, 16, 451471.
Byerly, M. J., Weber, M. T., Brooks, D. L. et al (2001) Antipsychotic medications and the elderly: effects on cognition and implications for use. Drugs and Aging, 18, 4561.
Chengappa, K. N. R., Baker, R. W., Kreinbrook, S. B. et al (1995) Clozapine use in female geriatric patients with psychosis. Journal of Geriatric Psychiatry and Neurology, 8, 1215.
Committee on Safety of Medicines – Medicines Control Agency (1995) Cardiac arrhythmias with pimozide (Orap). Current Problems in Pharmacovigilance, 21, 1.
Committee on Safety of Medicines – Medicines Control Agency (1999) Suspension of availability of sertindol (Serdolect). Current Problems in Pharmacovigilance, 25, 1.
De Deyn, P. P. & Katz, I. R. (2000) Control of aggression and agitation in patients with dementia: efficacy and safety of risperidone. International Journal of Geriatric Psychiatry, 15, S14S22.
De Deyn, P. P., Rabheru, K., Rasmussen, A. et al (1999) A randomised trial of risperidone, placebo, and haloperidol for behavioural symptoms of dementia. Neurology, 53, 946955.
Dewey, R. B. & O'Suilleabhain, P. E. (2000) Treatment of drug-induced psychosis with quetiapine and clozapine in Parkinson's disease. Neurology, 55, 1753.
Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975) ‘Mini-Mental State’: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Goetz, C. G., Blasucci, L. M. & Leurgan, S. (2000) Olanzapine and clozapine: comparative effects on motor function in hallucinating PD patients. Neurology, 55, 789794.
Howanitz, E., Pardo, M., Smelson, D.A. et al (1999) The efficacy and safety of clozapine versus chlorpromazine in geriatric schizophrenia. Journal of Clinical Psychiatry, 60, 4144.
Jeste, D. V., Caligiuri, M. P., Paulsen, J. S. et al (1995) Risk of tardive dyskinesia in older patients: a prospective longitudinal study of 266 outpatients. Archives of General Psychiatry, 52, 756765.
Jeste, D. V., Okamoto, A., Napolitano, J. et al (2000) Low incidence of tardive dyskinesia in elderly patients with dementia treated with risperidone. American Journal of Psychiatry, 157, 11501155.
Katz, I. R., Jeste, D. V., Mintzer, J. E. et al (1999) Comparison of risperidone and placebo for psychological and behavioural disturbances associated with dementia: a randomised double blind trial. Journal of Clinical Psychiatry, 60, 107115.
Kelly, H. G., Fay, J. E. & Laverty, S. G. (1963) Thioridazine hydrochloride (Melleril): its effect on the electrocardiogram and a report of two fatalities with electrocardiographic abnormalities. Journal of the Canadian Medical Association, 89, 546554.
Lanctot, K. L., Best, T. S., Mittmann, N. et al (1998) Efficacy and safety of neuroleptics in behavioural disorders associated with dementia. Journal of Clinical Psychiatry, 59, 550561.
Madhusoodanan, S., Brenner, R., Suresh, P. et al (2000) Efficacy and tolerability in elderly patients with psychotic disorders: a prospective study. Annals of Clinical Psychiatry, 12, 1118.
Maixner, S. M., Mellow, A. M. & Tandon, R. (1999) The efficacy, safety and tolerability of antipsychotics in the elderly. Journal of Clinical Psychiatry, 60 (suppl. 8), 2941.
McManus, D. Q., Arvanitis, L. A. & Kowalcyk, B. B. (1999) Quetiapine, a novel antipsychotic: experience in elderly patients with psychotic disorders. Journal of Clinical Psychiatry, 60, 292298.
McShane, R., Keene, J., Gedling, K. et al (1997) Do neuroleptic drugs hasten cognitive decline in dementia? Prospective study with necropsy follow up. BMJ, 314, 266270.
OHRMS (2001) Clinically Important QT Interval Prolongation with Three Antipsychotics. Pfizer Study 054. Bethesda, MD: Food and Drug Adminstration (http://www.fda.gov/ohrms/dockets/ac/).
Overall, J. E. & Gorham, D. R. (1962) The Brief Psychiatric Rating Scale. Psychological Reports, 10, 799812.
Reilly, J. G., Ayis, S. A., Ferrier, I. N. et al (2000) QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet, 355, 10481052.
Reisberg, B., Borenstein, J., Salob, S. P. et al (1987) Behave– AD. Journal of Clinical Psychiatry, 48 (suppl.), 915.
Sajatovic, M., Jaskiw, G., Konicki, P. E. et al (1997) Outcome of clozapine therapy for elderly patients with refractory primary psychosis. International Journal of Geriatric Psychiatry, 12, 553558.
Sajatovic, M., Ramirez, L. F., Garver, D. et al (1998a) Clozapine therapy for older veterans. Psychiatric Services, 49, 340344.
Sajatovic, M., Perez, D., Brescan, D. et al (1998b) Olanzapine therapy in elderly patients with schizophrenia. Psychopharmacology Bulletin, 34, 819823.
Satterlee, W. G., Reams, S. G., Burns, P. R. et al (1995) A clinical update on olanzapine treatment in schizophrenia and in elderly Alzheimer's disease patients (abstract). Psychopharmacology Bulletin, 31, 534.
Schneider, L. S., Pollock, V. E. & Lyness, S. A. (1990) A meta-analysis of controlled trials of neuroleptic treatment in dementia. Journal of the American Geriatrics Society, 38, 553563.
Schneider, L., Yeung, P., Sweitzer, D. et al (1999) Quetiapine may reduce hostility in patients with psychoses related to Alzheimer's disease. Schizophrenia Research, 36, 295296.
Street, J. S., Clark, W. S., Gannon, K. S. et al (2000) Olanzapine treatment of psychotic and behavioral symptoms in patients with alzheimer disease in nursing care facilities. Archives of General Psychiatry, 57, 968976.
Sweet, R. A. & Pollock, B. G. (1998) New atypical antipsychotics. Drugs and Aging, 12, 115127.
Tariot, P. N., Salzman, C., Yeung, P. P. et al (2000) Long-term use of quetiapine in elderly patients with psychotic disorders. Clinical Therapeutics, 22, 10681084.
Parkinson Study Group (1999) Low-dose clozapine for the treatment of drug-induced psychosis in Parkinson's disease. New England Journal of Medicine, 340, 757763.
Verhaeverbeke, I. & Mets, T. (1997) Drug-induced orthostatic hypotension in the elderly: avoiding its onset. Drug Safety, 17, 105118.
Wahlbeck, K., Cheine, M., Essali, A. et al (1999) Evidence of clozapine's effectiveness in schizophrenia: a systematic review and meta-analysis of randomised trials. American Journal of Psychiatry, 156, 990999.

Related content

Powered by UNSILO

Use of atypical antipsychotic drugs in old age psychiatry

  • Walter Pierre Bouman and Gill Pinner

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.

Use of atypical antipsychotic drugs in old age psychiatry

  • Walter Pierre Bouman and Gill Pinner
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *