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Adaptation of the Egs4 Monte Carlo Fode for the Design of a Polarized Source for X-Ray Fluorescence Analysis of Platinum and Other Heavy Metals In Vivo

Published online by Cambridge University Press:  06 March 2019

D.G. Lewis ,
G. Lewis  and
C.A. Oggt
D.G. Lewis
Affiliation:
Swansea In Vivo Analysis Research Group Department of Physics, University of Wales, Swansea SA2 8PP, UK
G. Lewis
Affiliation:
Swansea In Vivo Analysis Research Group Department of Physics, University of Wales, Swansea SA2 8PP, UK
C.A. Oggt
Affiliation:
Swansea In Vivo Analysis Research Group Department of Medical Physics, Singleton Hospital, Swansea SA2 8QA, UK
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Extract

X-ray fluorescence (XRF) has become a well established technique for the measurement of trace levels of toxic heavy metals in vivo, including cadmium, platinum, mercury and lead (Mattsson et al.. 1987). The clinical motivation for the measurement of platinum (Pt) is the need to investigate the kinetics of Pt-based cancer chemotherapy drugs such as cisplatin and paraplatin. Currently the main research interest in Swansea lies in the study of the uptake and distribution of Pt administered during chemotherapy of patients with tumours in the head and neck region.

Type
VIII. In Vivo Applications of XRS
Information
Advances in X-Ray Analysis , Volume 38: Forty-third Annual Conference on Applications of X-ray Analysis , 1994 , pp. 579 - 585
Copyright
Copyright © International Centre for Diffraction Data 1994

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References

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