Hostname: page-component-76fb5796d-vvkck Total loading time: 0 Render date: 2024-04-29T10:42:45.398Z Has data issue: false hasContentIssue false
  • English
  • Français

Some Remarks on the Genetics of Leprosy Resistance*

Published online by Cambridge University Press:  01 August 2014

B. Beiguelman
B. Beiguelman*
Affiliation:
Dept. of Medical Genetics, University of Campinas, São Paulo
*
Dept. of Medical Genetics, University of Campinas, São Paulo, Brazil

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The mechanism and the familial pattern of the late lepromin reaction (Mitsuda reaction) have been discussed. The interpretation of the familial correlation as mainly depending on a pair of allelic genes has been analysed thoroughly. A new technique has been described for identifying constitutional resistance or susceptibility to leprosy at an in vitro tissular level. The possibilities of this technique have been stressed.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 17 , Issue 4 , October 1968 , pp. 584 - 594
Copyright
Copyright © The International Society for Twin Studies 1968

Footnotes

*

This work was supported by grants from the World Health Organization and Fundação de Amparo à Pesquisa do Estado de São Paulo.

References

Bechelli, L. M., Rotberg, A. (1956). Compêndio de Leprologia. 2nd Ed., Rio de Janeiro.Google Scholar
Bechelli, L. M., Rath De Souza, P., Quagliato, R. (1959). Correlação entre os resultados da leitura clinica e do exame histopatòlogico da reação de Mitsuda. Rev. Brasil Lepr., 27: 172.Google Scholar
Beiguelman, B. (1962a). Grupos sanguíneos e lepra. Ciência e Cultura, 14: 260.Google Scholar
Beiguelman, B. (1962 b). Reação gustativa à fenil-tio-carbamida e lepra. Rev. Brasil Lepr., 30: 111.Google Scholar
Beiguelman, B. (1962 c). Hereditariedade da reação de Mitsuda. Rev. Brasil Lepr., 30: 153.Google Scholar
Beiguelman, B. (1963). Grupos sanguíneos e lepra. Rev. Brasil Lepr., 31: 34.Google Scholar
Beiguelman, B. (1964 a). Taste sensitibity to phenylthiourea among patients affected with both tuberculosis and leprosy. A.Ge.Me.Ge., 13: 190.Google Scholar
Beiguelman, B. (1964 b). Taste sensitivity to phenylthiourea and leprosy. A.Ge.Me.Ge., 13: 193.Google Scholar
Beiguelman, B. (1964 c). Sistema ABO e epidemiologia de lepra. Rev. Paul. Med., 65: 80.Google Scholar
Beiguelman, B. (1965 a). The genetics of resistance to leprosy. Int. J. Leprosy, 33: 808.Google Scholar
Beiguelman, B. (1965b). Genética e epidemiologia das doenças transmíssiveis com especial referência a lepra. Ciência e Cultura, 17: 449.Google Scholar
Beiguelman, B. (1966). Further results on the genetics of leprosy resistance. Proceed. IIIrd Intern. Congr. Hum. Genet., Chicago.Google Scholar
Beiguelman, B., Marques, M. B. (1964). Taste sensitivity to phenylthiourea and drugs with antileprotic effect. A.Ge.Me.Ge., 13: 200.Google ScholarPubMed
Beiguelman, B., Quagliato, R. (1964). Sobre a reação de Mitsuda. Rev. Brasil Lepr., 32: 39.Google ScholarPubMed
Beiguelman, B., Quagliato, R. (1965). Nature and familial character of the lepromin reactions. Int. J. Leprosy, 33: 800.Google ScholarPubMed
Beiguelman, B., Quagliato, R., Camargo, D. P. (1965). Influence of repeated lepromin injections on the Mitsuda skin reaction. Int. J. Leprosy, 33: 795.Google Scholar
Beiguelman, B., Souza Campos, N., Pinto, W. Jr. (1967). Fatores genéticos e efeito da calmetização na reação de Mitsuda. Rev. Paul. Med., 71: 271.Google ScholarPubMed
Beiguelman, B., Dall'Aglio, F. F., Da Silva, E. (1968 a). Analise de recorrência familiar de lepra. Rev. Paul. Med. 72: 105.Google Scholar
Beiguelman, B., Dall'Aglio, F. F., Da Silva, E. (1968 b). Estudo das formas polares de lepra pela analise de pares de irmãos. Rev. Paul. Med. 72: 111.Google Scholar
Beiguelman, B., Pinto, W. Jr., Dall'Aglio, F. F., Da Silva, E., Vozza, J. A. (1966). Deficiência da desidrogenase de 6-fosfato de glicose (G-6-PD) e lepra. Ciência e Cultura, 18: 95.Google Scholar
Beiguelman, B., Pinto, W. Jr., Dall'Aglio, F. F., Da Silva, E., Vozza, J. A. (1968). G-6-PD deficiency among lepers and healthy people in Brazil. Acta Genet. Basel, 18: 159.Google Scholar
Fisher, R. A. (1939). In Taylor, G. L. and Prior, A. M.: Blood groups in England. III. Discussion of familial material. Ann. Eugen., 9: 18.Google Scholar
Furtado, T. A., Schultz, K. H. (1965). Reatividade leprominica em individuos com tuberculose cutanea provenientes de area não endêmica de lepra. Rev. Brasil Lepr., 33: 75.Google Scholar
Gehr, R., Munder, A. M. (1954). Die Lepromin Reaktion bei verschiedenen Vollsgruppen in Suriname. Z. Tropenmed. Parasit., 5: 379.Google Scholar
Hadler, W. A., Ferreira, A. L., Ziti, L. M. (1965). An attempt to stimulate and depress the functional activity of the inflammatory cells from lesions experimentally induced by M. leprae and M. lepraemurium. Leprosy Rev., 36: 163.Google Scholar
Humphry, A. H. (1952). Leprosy amongst full-blooded aborigines in the Northern Territory. Med. J. Aust., 39: 570.Google Scholar
Lurie, M. B., Abramson, S., Harris, T. N., Allison, M. J., Heppleston, A. G. (1949). Constitutional factors in resistance to infection. I, II and III. Amer. Rev. Tuberc, 59: 168, 186, 198.Google Scholar
Lurie, M. B., Zappasodi, P., Dannenberg, A. M. Jr., Swarts, I. B. (1951). Constitutional factors in resistance to infection. The effect of cortisone on the pathogenesis of tuberculosis. Science, 113: 234.CrossRefGoogle ScholarPubMed
Lurie, M. B., Zappasodi, P., Cardona-Lynch, E., Dannenberg, A. M. Jr. (1952). The response to the intracutaneous inoculation of BGG as an index of native resistance to tuberculosis. J. Immun., 68: 369.CrossRefGoogle Scholar
Do Pateo, D., Pereira, N. S. (1936). Da frequência de lepra nos focos familiäres. Estudo epidemiologico. Rev. Brasil Lepr., 4: 241.Google Scholar
Petit, J. H. S., Chin, J. (1964). Does glucose-6-phosphate dehydrogenase deficiency modify the course of leprosy or its treatment? Leprosy Rev., 35: 149.CrossRefGoogle Scholar
Pinto, W. Jr., Beiguelman, B. (1967). Taxa de ilegitimidade e lepra. Rev. Paul. Med., 71: 267.Google Scholar
Povey, M. S., Hornton, R. J. (1966). Leprosy and blood groups. Rev. Brasil Lepr., 37: 147.Google Scholar
Quagliato, R. (1957). Lepra conjugal. Rev. Brasil Lepr., 25: 59.Google ScholarPubMed
Rotberg, A. (1957 a). Fator “ N ” de resistência à lepra e relaçoes com a reatividade lepromínica e tuberculínica. Valor duvidoso do BCG na imunização antileprosa. Rev. Brasil Lepr., 25: 245.Google Scholar
Rotberg, A. (1957 b). Fundamentos doutrinarios das correlaçoes biologicas de lepra e tuberculose. Rev. Brasil Lepr., 25: 245.Google Scholar
Salzano, F. M. (1967). Blood groups and leprosy. J. Med. Genet., 4: 102.Google Scholar
Sghwantes, A. R., Tondo, C. V., Salzano, F. M. (1963). Haptoglobinas e lepra. Ciência e Cultura, 15: 201.Google Scholar
Singh, G., Ojha, D. (1967). Leprosy and ABO blood groups. J. Med. Genet., 4: 107.CrossRefGoogle ScholarPubMed
Souza Campos, N., Leser, W., Bechelli, L. M., Quagliato, R., Rotberg, A. (1962). Viragem da lepromino-reação em funçã;o de diferentes estimulos. Influência da idade, nessa viragem, no grupo etario de 6 a 43 mêses. Rev. Brasil Lepr., 29: 3.Google Scholar
Verma, B. S., Dongre, A. V. (1965). Leprosy and ABO blood groups. Leprosy Rev., 36: 211.Google Scholar
Vogel, F. (1967). ABO blood groups and leprosy. J. Med. Genet. (In press).Google Scholar
Vogel, F., Chakravartti, M. R. (1966). ABO blood groups and the type of leprosy in an Indian population. Humangenetik, 3: 186.Google Scholar
Yankah, J. A. K. (1965). Observation on the frequency of ABO and Rh blood groups in leprosy and non-leprosy people in Ghana. Leprosy Rev., 36: 73.Google Scholar