Skip to main content Accessibility help
×
Home

Twin Study on Myopia

  • L.L.-K. Lin (a1) and C.-J. Chen (a1)

Abstract

In order to reassess the relative importance of genetic and environmental factors in the development of myopia in Chinese schoolchildren, 90 pairs of MZ and 36 pairs of like-sex DZ twins were enrolled for detailed ophthalmological examination about their ocular refractions. Corneal curvatures and axial lengths were also measured. With equivalent settings of the range for concordance, corneal curvatures showed higher concordance rate (84%) than ocular refractions (65%) and axial lenghts (59%) in MZ twins. F-test on the intrapair variances between MZ and DZ twins revealed a significant hereditary role in determining the ocular refraction and its optical components. The degree of genetic determination was expressed by heritability indices, which were derived from intraclass correlation coefficients. The diversity of sample ages and refractions, while making the obtained data difficult to further explore the gene-environment interaction, led to the observation of more intrapair differences with age and myopic progression in MZ twins.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Twin Study on Myopia
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Twin Study on Myopia
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Twin Study on Myopia
      Available formats
      ×

Copyright

Corresponding author

Department of Ophthalmology, National Taiwan University Hospital, 1 Chang-Te Street, Taipei, Taiwan

References

Hide All
1. Chen, CJ, Cohen, BH, Diamond, EL (1985): Genetic and environmental effects on the development of myopia in Chinese twin children. Ophthal Paediatr Genet 6:113119.
2. Chen, CJ, Lin, LK, Hung PT (1986): Nation-wide survey of myopia in Taiwan: a preliminary report. Presented at the Third International Conference on Myopia, Rome.
3. Lai, CY, Huang, WL, Sheu, MM, Chen, CW (1983): Refractive status of students in Kaohsiung Medical College. Trans Soc Ophthal Sin 22:1420.
4. Lin, LK (1985): Epidemiological Study on Myopia Among Schoolchildren in Taiwan. Doctorate thesis. Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University.
5. Lin, LK, Hung, LF, Shih, YF, Hung, PT, Ko, LS (1986): Correlation of optical components with ocular refraction among teenagers in Taipei. Presented at the Third International Conference on Myopia, Rome.
6. Schwartz, JT (1968): Twin studies in ophthalmology. Am J Ophthalmol 66:323327.
7. Shih, YF, Wang, AH, Ko, LS (1984): The refractive status of clerks in College of Medicine, National Taiwan University. Presented at the 25th annual meeting of the Ophthalmological Society of R.O.C., Taipei.
8. Sorsby, A, Sheridan, M, Leary, GA (1962): Refraction and its components in twins. Medical Research Council Special Report Series N 303. London: HMSO.
9. Sorsby, A (1982): Biology of the eye asan optical system. In Duane, (ed): Clinical Ophthalmology, Vol 1, Chapter 34 New York: Harper & Row.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed