Aarestrup, FM (1999). Association between the consumption of antimicrobial agents in animal husbandry and the occurrence of resistant bacteria among food animals. International Journal of Antimicrobial Agents 12: 279–285.
Aarestrup, FM, Rasmussen, SR, Artursson, K and Jensen, NE (1998). Trends in the resistance to antimicrobial agents of Streptococcus suis isolates from Denmark and Sweden. Veterinary Microbiology 63: 71–80.
Amass, SF, Struve, R, Clark, LK and Wu, CC (1996a). Cesarean section: a surgical method to derive pigs free of Streptococcus suis. Swine Health and Production 4: 196–198.
Amass, SF, Wu, CC and Clark, LK (1996b). Evaluation of antibiotics for the elimination of the tonsillar carrier state of Streptococcus suis in pigs. Journal of Veterinary Diagnostic Investigation 8: 64–67.
Amass, SF, SanMiguel, P and Clark, LK (1997). Demonstration of vertical transmission of Streptococcus suis in swine by genomic fingerprinting. Journal of Clinical Microbiology 35: 1595–1596.
Amass, SF, Stevenson, GW, Knox, KE and Reed, AJ (1999). Efficacy of an autogenous vaccine for preventing streptococcosis in piglets. Veterinary Medicine 94: 480–484.
Amass, SF, Stevenson, GW, Bryan, D, Vyverberg, BD, Huxford, TW, Knox, KE and Grote, LA (2000). Administration of a homologous bacterin to sows prefarrowing provided partial protection against streptoccosis in their weaned pigs. Journal of Swine and Health Production 8: 217–219.
Berthelot-Herault, F, Gottschalk, M, Labbe, A, Cariolet, R and Kobisch, M (2001). Experimental airborne transmission of Streptococcus suis capsular type 2 in pigs. Veterinary Microbiology 82: 69–80.
Blackwell, T (2005). Effective treatment and handling of poor doing pigs in the finishing barn. In: Conference Proceedings, London Swine Conference, London, Ontario, p. 167.
Brisebois, LM, Charlebois, R, Higgins, R and Nadeau, M (1990). Prevalence of Streptococcus suis in four to eight week old clinically healthy piglets. Canadian Journal of Veterinary Research 54: 174–177.
Busque, P, Higgins, R, Caya, F and Quessy, S (1997). Immunization of pigs against Streptococcus suis serotype 2 infection using a live avirulent strain. Canadian Journal of Veterinary Research 61: 275–279.
Byra, C, Gadbois, P, Cox, WR, Gottschalk, M, Farzan, V, Bauer, SA and Wilson, JB (2011). Decreased mortality of weaned pigs with Streptococcus suis with the use of in-water potassium penicillin G. Canadian Veterinary Journal 52: 272–276.
Cain, D, Malouin, F, Dargis, M, Harel, J and Gottschalk, M (1995). Alterations in penicillin-binding proteins in strains of Streptococcus suis possessing moderate and high levels of resistance to penicillin. FEMS Microbiology Letters 130: 121–127.
Cantin, M, Harel, J, Higgins, R and Gottschalk, M (1992). Antimicrobial resistance patterns and plasmid profiles of Streptococcus suis isolates. Journal of Veterinary Diagnostic Investigation 4: 170–174.
Clifton-Hadley, FA, Alexander, TJ, Enright, MR and Guise, J (1984). Monitoring herds for Streptococcus suis type 2 by sampling tonsils of slaughter pigs. Veterinary Record 115: 562–564.
Cloutier, G, D'Allaire, S, Martinez, G, Surprenant, C, Lacouture, S and Gottschalk, M (2003). Epidemiology of Streptococcus suis serotype 5 infection in a pig herd with and without clinical disease. Veterinary Microbiology 97: 135–151.
Dee, SA and Corey, MM (1993). The survival of Streptococcus suis on farm and veterinary equipment. Swine Health and Production 1: 17–20.
Dee, SA, Carlson, AR, Winkelman, NL and Corey, MM (1993). Effect of management practices on the Streptococcus suis carrier rate in nursery swine. Journal of the American Veterinary Medical Association 203: 295–299.
del Campo Sepulveda, EM, Altman, E, Kobisch, M, D'Allaire, S and Gottschalk, M (1996). Detection of antibodies against Streptococcus suis capsular type 2 using a purified capsular polysaccharide antigen-based indirect ELISA. Veterinary Microbiology 52: 113–125.
Done, S and Burch, D (2007). Prevention and control of respiratory diseases excluding Mycoplasma Hyopneumoniae. Thai Journal of Veterinary Medicine 37: 9–20.
Escudero, JA, San Millan, A, Catalan, A, de la Campa, AG, Rivero, E, Lopez, G, Dominguez, L, Moreno, MA and Gonzalez-Zorn, B (2007). First characterization of fluoroquinolone resistance in Streptococcus suis. Antimicrobial Agents and Chemotherapy 51: 777–782.
Escudero, JA, San Millan, A, Gutierrez, B, Hidalgo, L, La Ragione, RM, AbuOun, M, Galimand, M, Ferrandiz, MJ, Dominguez, L, de la Campa, AG and Gonzalez-Zorn, B (2011). Fluoroquinolone efflux in Streptococcus suis is mediated by SatAB and not by SmrA. Antimicrobial Agents and Chemotherapy 55: 5850–5860.
Feng, Y, Shi, X, Zhang, H, Zhang, S, Ma, Y, Zheng, B, Han, H, Lan, Q, Tang, J, Cheng, J, Gao, GF and Hu, Q (2009). Recurrence of human Streptococcus suis infections in 2007: three cases of meningitis and implications that heterogeneous S. suis 2 circulates in China. Zoonoses and Public Health 56: 506–514.
Feng, Y, Zhang, H, Ma, Y and Gao, GF (2010). Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent. Trends in Microbiology 18: 124–131.
Friendship, RM (2006). Antimicrobial drug use in swine. In: Giguere, S, Prescott, JF, Baggot, JD, Walker, RD and Dowling, PM (eds) Antimicrobial Therapy in Veterinary Medicine. Iowa: Blackwell Publishing, p. 538.
Galina, L, Vecht, U, Wisselink, HJ and Pijoan, C (1996). Prevalence of various phenotypes of Streptococcus suis isolated from swine in the U.S.A. based on the presence of muraminidase-released protein and extracellular factor. Canadian Journal of Veterinary Research 60: 72–74.
Ge, Y, Wu, J, Xia, Y, Yang, M, Xiao, J and Yu, J (2012). Molecular dynamics simulation of the complex PBP-2x with drug cefuroxime to explore the drug resistance mechanism of Streptococcus suis R61. PLoS ONE 7: e35941.
Gottschalk, M and Segura, M (2000). The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions 76: 259–272.
Gottschalk, M (2004). Porcine Streptococcus suis strains as potential sources of infections in humans: an underdiagnosed problem in North America? Journal of Swine and Health Production 12: 197–199.
Gottschalk, M (2012). Streptococcosis. In: Zimmerman, JJ, Karriker, LA, Ramirez, A, Schwartz, KJ and Stevenson, GW (eds) Diseases of Swine, 10th edn. Iowa: Blackwell Publishing, pp. 841–855.
Gottschalk, M, Higgins, R, Jacques, M, Beaudoin, M and Henrichsen, J (1991a). Isolation and characterization of Streptococcus suis capsular types 9–22. Journal of Veterinary Diagnostic Investigation 3: 60–65.
Gottschalk, M, Turgeon, P, Higgins, R, Beaudoin, M and Bourgault, AM (1991b). Susceptibility of Streptococcus suis to penicillin. Journal of Veterinary Diagnostic Investigation 3: 170–172.
Gottschalk, M, Lebrun, A, Wisselink, H, Dubreuil, JD, Smith, H and Vecht, U (1998). Production of virulence-related proteins by Canadian strains of Streptococcus suis capsular type 2. Canadian Journal of Veterinary Research 62: 75–79.
Gottschalk, M, Segura, M and Xu, J (2007). Streptococcus suis infections in humans: the Chinese experience and the situation in North America. Animal Health Research Reviews 8: 29–45.
Gottschalk, M, Xu, J, Calzas, C and Segura, M (2010). Streptococcus suis: a new emerging or an old neglected zoonotic pathogen? Future Microbiology 5: 371–391.
Halbur, P, Thanawongnuwech, R, Brown, G, Kinyon, J, Roth, J, Thacker, E and Thacker, B (2000). Efficacy of antimicrobial treatments and vaccination regimens for control of porcine reproductive and respiratory syndrome virus and Streptococcus suis coinfection of nursery pigs. Journal of Clinical Microbiology 38: 1156–1160.
Haleis, A, Alfa, M, Gottschalk, M, Bernard, K, Ronald, A and Manickam, K (2009). Meningitis caused by Streptococcus suis serotype 14, North America. Emerging Infectious Diseases 15: 350–352.
Hawkey, PM (2008). The growing burden of antimicrobial resistance. Journal of Antimicrobial Chemotherapy 62: 1–9.
Hendriksen, RS, Mevius, DJ, Schroeter, A, Teale, C, Jouy, E, Butaye, P, Franco, A, Utinane, A, Amado, A, Moreno, M, Greko, C, Stark, KD, Berghold, C, Myllyniemi, AL, Hoszowski, A, Sunde, M and Aarestrup, FM (2008). Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002–2004: the ARBAO-II study. Acta Veterinaria Scandinavica 50: 19.
Higgins, R and Gottschalk, M (1999). Streptococcal diseases. In: Straw, BE, D'Allaire, S, Mengeling, WL and Taylor, DJ (eds) Diseases of Swine, 8th edn. Iowa: Blackwell Publishing, pp. 563–578.
Higgins, R and Gottschalk, M (2000). Distribution of Streptococcus suis capsular types in 1999. Canadian Veterinary Journal 41: 414.
Higgins, R, Gottschalk, M, Mittal, KR and Beaudoin, M (1990). Streptococcus suis infection in swine. A sixteen month study. Canadian Journal of Veterinary Research 54: 170–173.
Hoa, NT, Chieu, TT, Nghia, HD, Mai, NT, Anh, PH, Wolbers, M, Baker, S, Campbell, JI, Chau, NV, Hien, TT, Farrar, J and Schultsz, C (2011). The antimicrobial resistance patterns and associated determinants in Streptococcus suis isolated from humans in southern Vietnam, 1997–2008. BMC Infectious Diseases 11: 6.
Holt, ME, Enright, MR and Alexander, TJ (1990). Protective effect of sera raised against different fractions of Streptococcus suis type 2. Journal of Comparative Pathology 103: 85–94.
Holtkamp, D, Rotto, H and Garcia, R (2007). The economic cost of major health challenges in large US swine production systems. In: Conference Proceedings, American Association of Swine Veterinarians. Orlando, FL, 3–6 March 2007. p. 85.
Hu, P, Yang, M, Zhang, A, Wu, J, Chen, B, Hua, Y, Yu, J, Chen, H, Xiao, J and Jin, M (2011). Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain. PLoS ONE 6: e24988. doi:10.1371/journal.pone.0024988.
Jacobs, AA, van den Berg, AJ and Loeffen, PL (1996). Protection of experimentally infected pigs by suilysin the thio-activated haemolysin of Streptococcus suis. Vetinary Record 139: 225–228.
Jensen, HE, Gyllensten, J, Hofman, C, Leifsson, PS, Agerholm, JS, Boye, M and Aalbaek, B (2010). Histologic and bacteriologic findings in valvular endocarditis of slaughter-age pigs. Journal of Veterinary Diagnostic Investigation 22: 921–927.
Jensen, J and Dorseen van, CA (1957). Meningo-encephalitis bij vafkens door streptococcen. Tijdschrift voor diergeneeskunde 76: 815–832.
Jones, JE (1981). Experimental streptococcal endocarditis in the pig: the development of lesions 3 to 14 days after inoculation. Journal of Comparative Pathology 91: 51–62.
Karstrup, CC, Jensen, HE, Aalbaek, B, Leifsson, PS, Boye, M and Agerholm, JS (2011). Endocarditis-associated brain lesions in slaughter pigs. Journal of Comparative Pathology 144: 289–295.
Kataoka, Y, Yoshida, T and Sawada, T (2000). A 10-year survey of antimicrobial susceptibility of Streptococcus suis isolates from swine in Japan. Journal of Veterinary Medical Science 62: 1053–1057.
Keenliside, J, Gamroth, A, Bystrom, J and Perry, A (2006). Carcass trims – a look at arthritis and adhesions trims from severely affected herds. Advances in Pork Production 17: 187–192.
Kolar, M, Urbanek, K and Latal, T (2001). Antibiotic selective pressure and development of bacterial resistance. International Journal of Antimicrobial Agents 17: 357–363.
Lapointe, L, D'Allaire, S, Lebrun, A, Lacouture, S and Gottschalk, M (2002). Antibody response to an autogenous vaccine and serologic profile for Streptococcus suis capsular type 1/2. Canadian Journal of Veterinary Research 66: 8–14.
Li, Y, Martinez, G, Gottschalk, M, Lacouture, S, Willson, P, Dubreuil, JD, Jacques, M and Harel, J (2006). Identification of a surface protein of Streptococcus suis and evaluation of its immunogenic and protective capacity in pigs. Infection and Immunology 74: 305–312.
Lun, ZR, Wang, QP, Chen, XG, Li, AX and Zhu, XQ (2007). Streptococcus suis: an emerging zoonotic pathogen. Lancet Infectious Diseases 7: 201–209.
Ma, E, Chung, PH, So, T, Wong, L, Choi, KM, Cheung, DT, Kam, KM, Chuang, SK and Tsang, T (2008). Streptococcus suis infection in Hong Kong: an emerging infectious disease? Epidemiology and Infection 136: 1691–1697.
MacInnes, JI and Desrosiers, R (1999). ‘Agents of the ‘ S. suis-ide diseases’ of swine: Actinobacillus S. suis, Haemophilus para S. suis, and Streptococcus suis’. Canadian Journal of Veterinary Research 63: 83–89.
MacInnes, JI, Gottschalk, M, Lone, AG, Metcalf, DS, Ojha, S, Rosendal, T, Watson, SB and Friendship, RM (2008). Prevalence of Actinobacillus pleuropneumoniae, Actinobacillus suis, Haemophilus parasuis, Pasteurella multocida, and Streptococcus suis in representative Ontario swine herds. Canadian Journal of Veterinary Research 72: 242–248.
Marie, J, Morvan, H, Berthelot-Hérault, F, Sanders, P, Kempf, I, Gauthier-Bouchardon, AV, Jouy, E and Kobisch, M (2002). Antimicrobial susceptibility of Streptococcus suis isolated from swine in France and from humans in different countries between 1996 and 2000. Journal of Antimicrobial Chemotherapy 50: 201–209.
Martel, A, Baele, M, Devriese, LA, Goossens, H, Wisselink, HJ, Decostere, A and Haesebrouck, F (2001). Prevalence and mechanism of resistance against macrolides and lincosamides in Streptococcus suis isolates. Veterinary Microbiology 83: 287–297.
McEwen, SA and Fedorka-Cray, PJ (2002). Antimicrobial use and resistance in animals. Clinical Infectious Diseases 34: 93–106.
McKellar, QA, Baxter, P, Taylor, D and Bogan, JA (1987). Penicillin therapy of spontaneous streptococcal meningitis in pigs. Veterinary Record 121: 347–350.
Messier, S, Lacouture, S and Gottschalk, M (2008). Distribution of Streptococcus suis capsular types from 2001 to 2007. Canadian Veterinary Journal 49: 461–462.
Michaud, S, Duperval, R and Higgins, R (1996). Streptococcus suis meningitis first case reported in Quebec. Canadian Journal of Infectious Diseases 7: 329–331.
Neumann, EJ, Ramirez, A and Schwartz, KJ (2009). Streptococcal infections. In: Neumann, EJ, Ramirez, A and Schwartz, KJ (eds) Swine Disease Manual, 4th edn. Iowa: American Association of Swine Veterinarians, pp. 39–40.
Osweiler, G (2003). Summary of selected swine assays and results for 2003 from the Iowa State University Veterinary Diagnostic Laboratory. In: Conference Proceedings, 11th Annual Swine Disease Conference for Swine Practitioners, Iowa, p. 188.
Palmieri, C, Varaldo, PE and Facinelli, B (2011). Streptococcus suis, an emerging drug-resistant animal and human pathogen. Frontiers in Microbiology 2: 235.
Quessy, S, Dubreuil, JD, Caya, M, Letourneau, R and Higgins, R (1994). Comparison of pig, rabbit and mouse IgG response to Streptococcus suis serotype 2 proteins and active immunization of mice against the infection. Canadian Journal of Veterinary Research 58: 220–223.
Reams, RY, Glickman, LT, Harrington, DD, Bowersock, TL and Thacker, HL (1993). Streptococcus suis infection in swine: a retrospective study of 256 cases. Part I. Epidemiologic factors and antibiotic susceptibility patterns. Journal of Veterinary Diagnostic Investigation 5: 363–367.
Reams, RY, Glickman, LT, Harrington, DD, Thacker, HL and Bowersock, TL (1994). Streptococcus suis infection in swine: a retrospective study of 256 cases. Part II. Clinical signs, gross and microscopic lesions, and coexisting microorganisms. Journal of Veterinary Diagnostic Investigation 6: 326–334.
Reams, RY, Harrington, DD, Glickman, LT, Thacker, HL and Bowersock, TL (1996). Multiple serotypes and strains of Streptococcus suis in naturally infected swine herds. Journal of Veterinary Diagnostic Investigation 8: 119–121.
Smith, HE, Vecht, U, Wisselink, HJ, Stockhofe-Zurwieden, N, Biermann, Y and Smits, MA (1996). Mutants of Streptococcus suis types 1 and 2 impaired in expression of muramidase-released protein and extracellular protein induce disease in newborn germfree pigs. Infection and Immunity 64: 4409–4412.
Smith, TC, Capuano, AW, Boese, B, Myers, KP and Gray, GC (2008). Exposure to Streptococcus suis among US swine workers. Emerging Infectious Diseases 14: 1925–1927.
Staats, JJ, Feder, I, Okwumabua, O and Chengappa, MM (1997). Streptococcus suis: past and present. Veterinary Research Communications 21: 381–407.
Strangmann, E, Froleke, H and Kohse, KP (2002). Septic shock caused by Streptococcus suis: case report and investigation of a risk group. International Journal of Hygiene and Environmental Health 205: 385–392.
Thanawongnuwech, R, Brown, GB, Halbur, PG, Roth, JA, Royer, RL and Thacker, BJ (2000). Pathogenesis of porcine reproductive and respiratory syndrome virus-induced increase in susceptibility to Streptococcus suis infection. Veterinary Pathology 37: 143–152.
The Government of the Hong Kong Special Administrative Region (2005). Amendment to the Quarantine and Prevention of Disease Ordinance, Cap. 141. [Available online at http://www.chp.gov.hk/en/content/9/24/3648.html [accessed 3 April 2012].
Vela, AI, Moreno, MA, Cebolla, JA, Gonzalez, S, Latre, MV, Dominguez, L and Fernandez-Garayzabal, JF (2005). Antimicrobial susceptibility of clinical strains of Streptococcus suis isolated from pigs in Spain. Veterinary Microbiology 105: 143–147.
Walsh, B, Williams, AE and Satsangi, J (1992). Streptococcus suis type 2: pathogenesis and clinical disease. Reviews in Medical Microbiology 3: 65–71.
Wertheim, HF, Nghia, HD, Taylor, W and Schultsz, C (2009a). Streptococcus suis: an emerging human pathogen. Clinical Infectious Diseases 48: 617–625.
Wertheim, HF, Nguyen, HN, Taylor, W, Lien, TT, Ngo, HT, Nguyen, TQ, Nguyen, BN, Nguyen, HH, Nguyen, HM, Nguyen, CT, Dao, TT, Nguyen, TV, Fox, A, Farrar, J, Schultsz, C, Nguyen, HD, Nguyen, KV and Horby, P (2009b). Streptococcus suis, an important cause of adult bacterial meningitis in northern Vietnam. PLOS ONE 4: e5973.
Willenburg, KS, Sentochnik, DE and Zadoks, RN (2006). Human Streptococcus suis meningitis in the United States. New England Journal of Medicine 354: 1325.
Wisselink, HJ, Reek, FH, Vecht, U, Stockhofe-Zurwieden, N, Smits, MA and Smith, HE (1999). Detection of virulent strains of Streptococcus suis type 2 and highly virulent strains of Streptococcus suis type 1 in tonsillar specimens of pigs by PCR. Veterinary Microbiology 67: 143–157.
Wisselink, HJ, Smith, HE, Stockhofe-Zurwieden, N, Peperkamp, K and Vecht, U (2000). Distribution of capsular types and production of muramidase-released protein (MRP) and extracellular factor (EF) of Streptococcus suis strains isolated from diseased pigs in seven European countries. Veterinary Microbiology 74: 237–248.
Wisselink, HJ, Stockhofe-Zurwieden, N, Hilgers, LA and Smith, HE (2002). Assessment of protective efficacy of live and killed vaccines based on a non-encapsulated mutant of Streptococcus suis serotype 2. Veterinary Microbiology 84: 155–168.
Zhang, C, Ning, Y, Zhang, Z, Song, L, Qiu, H and Gao, H (2008). In vitro antimicrobial susceptibility of Streptococcus suis strains isolated from clinically healthy sows in China. Veterinary Microbiology 131: 386–392.