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Canine distemper, a re-emerging morbillivirus with complex neuropathogenic mechanisms

Published online by Cambridge University Press:  28 February 2007

Christian Griot ,
Marc Vandevelde ,
Martina Schobesberger  and
Andreas Zurbriggen
Christian Griot*
Affiliation:
Institute of Virology and Immunoprophylaxis, Swiss Federal Veterinary Office, 3147 Mittelhäusern, University of Bern, 3012 Bern, Switzerland Institute of Animal Neurology, University of Bern, 3012 Bern, Switzerland
Marc Vandevelde
Affiliation:
Institute of Animal Neurology, University of Bern, 3012 Bern, Switzerland
Martina Schobesberger
Affiliation:
Institute of Animal Neurology, University of Bern, 3012 Bern, Switzerland
Andreas Zurbriggen
Affiliation:
Institute of Animal Neurology, University of Bern, 3012 Bern, Switzerland
*
*Institute of Virology and Immunoprophylaxis, P.O. Box 17, Sensemattstrasse 293, CH-3147 Mittelhäusern, Switzerland E-mail: Christian.Griot@ivi.admin.ch Fax: +41(0)31 848 9222
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Abstract

Paramyxoviruses are responsible for a wide variety of diseases both in humans and in animals. Common to many paramyxoviruses is the fact that they can cause neurological symptoms in their final host. Newly discovered paramyxoviruses, such as the Hendra and Nipah viruses, show the same pattern of pathogenesis as that of the paramyxoviruses already known. Canine distemper virus (CDV) is a well-studied member of the genus Morbillivirus. Study of the neuropathogenesis of CDV might give insight into disease mechanisms and suggest approaches for the prevention of other recently discovered paramyxovirus infections.

Keywords

canine distempermorbillivirusdogshenipahneuropathology

Information

Type
Research Article
Information
Animal Health Research Reviews , Volume 4 , Issue 1 , June 2003 , pp. 1 - 10
Copyright
Copyright © CAB International 2003

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References

Alldinger, S, Baumgärtner, W and Örvell, C (1993 a). Restricted expression of viral surface proteins in canine distemper encephalitis. Acta Neuropathologica (Berlin) 85: 635–645.CrossRefGoogle ScholarPubMed
Alldinger, S, Baumgärtner, W, van Moll, P and Örvell, C (1993 b). In vivo and in vitro expression of canine distemper viral proteins in dogs and non-domestic carnivores. Archives of Virology 132: 421–428.CrossRefGoogle ScholarPubMed
Alldinger, S, Wunschmann, A, Baumgärtner, W, Voss, C and Kremmer, E (1996). Up-regulation of major histocompatibility complex class II antigen expression in the central nervous system of dogs with spontaneous canine distemper virus encephalitis. Acta Neuropathologica (Berlin) 92: 273–280.CrossRefGoogle ScholarPubMed
Appel, MJ (1969). Pathogenesis of canine distemper. American Journal of Veterinary Research 30: 1167–1182.Google ScholarPubMed
Appel, MJ, Glickman, LT, Raine, CS and Tourtellotte, WW (1981). Canine viruses and multiple sclerosis. Neurology 31: 944–949.CrossRefGoogle ScholarPubMed
Appel, MJ, Shek, WR and Summers, BA (1982). Lymphocyte-mediated immune cytotoxicity in dogs infected with virulent canine distemper virus. Infection and Immunity 37: 592–600.CrossRefGoogle ScholarPubMed
Appel, MJG, Yates, RA and Foley, GL (1994). Canine distemper epizootic in lions, tigers and leopards in North America. Journal of Veterinary Diagnostic Investigation 6: 277–288.CrossRefGoogle ScholarPubMed
Barben, G, Stettler, M, Jaggy, A, Vandevelde, M and Zurbriggen, A (1999). Detection of IgM antibodies against the nucleocapsid protein of canine distemper virus in dog sera using a dot-blot-assay. Journal of Veterinary Medicine A 46: 115–121.CrossRefGoogle ScholarPubMed
Barclay, AJ and Paton, DJ (2000). Hendra (equine morbillivirus). Veterinary Journal 160: 169–176.CrossRefGoogle ScholarPubMed
Barrett, T (1999). Morbillivirus infections, with special emphasis on morbilliviruses of carnivores. Veterinary Microbiology 69: 3–13.CrossRefGoogle ScholarPubMed
Barrett, T, Visser, IKG, Mamaev, L, Goatley, L, Van Bressem, MF and Osterhaus, ADME (1993). Dolphin and porpoise morbilliviruses are genetically distinct from phocine distemper virus. Virology 193: 1010–1012.CrossRefGoogle ScholarPubMed
Baumgärtner, W, Örvell, C and Reinacher, M (1989). Naturally occurring canine distemper virus encephalitis: distribution and expression of viral polypeptides in nervous tissues. Acta Neuropathologica 78: 504–512.CrossRefGoogle ScholarPubMed
Blakemore, WF, Summers, BA and Appel, MG (1989). Evidence of oligodendrocyte infection and degeneration in canine distemper encephalomyelitis. Acta Neuropathologica 77: 550–553.CrossRefGoogle ScholarPubMed
Bollo, E, Zurbriggen, A, Vandevelde, M and Fankhauser, R (1986). Canine distemper virus clearance in chronic inflammatory demyelination. Acta Neuropathologica 72: 69–73.CrossRefGoogle ScholarPubMed
Bolt, G, Jensen, TD, Gottschalck, E, Arctander, P, Appel, MJ, Buckland, R and Blixenkrone-Moller, M (1997). Genetic diversity of the attachment (H) protein gene of current field isolates of canine distemper virus. Journal of General Virology 78: 367–372.CrossRefGoogle ScholarPubMed
Botteron, C, Zurbriggen, A, Griot, C and Vandevelde, M (1992). Canine distemper virus-immune complexes induce bystander degeneration of oligodendrocytes. Acta Neuropathologica 83: 402–407.CrossRefGoogle ScholarPubMed
Brown, C (1997). Emerging diseases—what veterinarians need to know. Journal of Veterinary Diagnostic Investigation 9: 113–117.CrossRefGoogle ScholarPubMed
Brügger, M, Jungi, TW, Zurbriggen, A and Vandevelde, M (1992). Canine distemper virus increases procoagulant activity of macrophages. Virology 190: 616–623.CrossRefGoogle ScholarPubMed
Bürge, T, Griot, C, Vandevelde, M and Peterhans, E (1989). Antiviral antibodies stimulate production of reactive oxygen species in cultured canine brain cells infected with canine distemper virus. Journal of Virology 63: 2790–2797.CrossRefGoogle ScholarPubMed
Bush, M, Montali, RJ, Brownstein, D, James, AE Jr & Appel, MJ (1976). Vaccine-induced canine distemper in a lesser panda. Journal of the American Veterinary Medical Association 169: 959–960.Google Scholar
Carpenter, JW, Appel, MJ, Erickson, RC and Novilla, MN (1976). Fatal vaccine-induced canine distemper virus infection in black-footed ferrets. Journal of the American Veterinary Medical Association 169: 961–964.Google ScholarPubMed
Cerruti Sola, S, Kristensen, F, Vandevelde, M, Bichsel, P and Kihm, U (1983). Lymphocyte responsiveness to lectin and myelin antigens in canine distemper infection in relation to the development of demyelinating lesions. Journal of Neuroimmunology 4: 77–90.CrossRefGoogle Scholar
Cherpillod, P, Beck, K, Zurbriggen, A and Wittek, R (1999). Sequence analysis and expression of the attachment and fusion proteins of canine distemper virus wild-type strain A75/17. Journal of Virology 73: 2263–2269.CrossRefGoogle ScholarPubMed
Cherpillod, P, Tipold, A, Griot-Wenk, M, Cardozo, C, Schmid, I, Fatzer, R, Schobesberger, M, Zurbriggen, R, Bruckner, L, Roch, F, Vandevelde, M, Wittek, R and Zurbriggen, A (2000). DNA encoding nucleocapsid and surface proteins of wild type canine distemper virus protects its natural host against distemper. Vaccine 18: 2927–2936.CrossRefGoogle ScholarPubMed
Chua, KB, Goh, KJ, Wong, KT, Kamarulzaman, A, Tan, PS, Ksiazek, TG, Zaki, SR, Paul, G, Lam, SK and Tan, CT (1999). Fatal encephalitis due to Nipah virus among pig-farmers in Malaysia. Lancet 354: 1256–1259.CrossRefGoogle ScholarPubMed
Chua, KB, Bellini, WJ, Rota, PA, Harcourt, BH, Tamin, A, Lam, SK, Ksiazek, TG, Rollin, PE, Zaki, SR, Sheih, WJ, Goldsmith, CS, Gubler, DJ, Roehrig, JT, Eaton, B, Gould, AR, Olson, J, Field, H, Daniels, P, Ling, AE, Peters, CJ, Anderson, LJ and Mahy, WJ (2000). Nipah virus: a recently emergent deadly paramyxovirus. Science 288: 1432–1435.CrossRefGoogle ScholarPubMed
Chua, KB, Koh, CL, Hooi, PS, Wee, KF, Khong, JH, Chua, BH, Chan, YP, Lim, ME and Lam, SK (2002). Isolation of Nipah virus from Malaysian island flying-foxes. Microbes and Infection 4: 145–151.CrossRefGoogle ScholarPubMed
Cleaveland, S, Appel, MG, Chalmers, WS, Chillingworth, C, Kaare, M and Dye, C (2000). Serological and demographic evidence for domestic dogs as a source of canine distemper virus infection for Serengeti wildlife. Veterinary Microbiology 72: 217–227.CrossRefGoogle ScholarPubMed
Cleaveland, S, Laurenson, MK and Taylor, LH (2001). Diseases of humans and their domestic mammals: pathogen characteristics, host range and the risk of emergence. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences 356: 991–999.CrossRefGoogle ScholarPubMed
Cook, SD, Dowling, PC and Russell, WC (1979). Neutralizing antibodies to canine distemper and measles virus in multiple sclerosis. Journal of the Neurological Sciences 41: 61–70.CrossRefGoogle ScholarPubMed
Cook, SD and Dowling, PC (1980). Multiple sclerosis and viruses: an overview. Neurology 30: 80–91.CrossRefGoogle ScholarPubMed
Cook, SD, Gudmundsson, G, Benedikz, J and Dowling, PC (1980). Multiple sclerosis and distemper in Iceland 1966–1978. Acta Neurologica Scandinavica 61: 244–251.CrossRefGoogle ScholarPubMed
Cook, SD, Blumberg, B and Dowling, PC (1986). Potential role of paramyxoviruses in multiple sclerosis. Neurologic Clinics 4: 303–319.CrossRefGoogle ScholarPubMed
Cook, SD, Rohowsky-Kochan, C, Bansil, S and Dowling, PC (1995). Evidence for multiple sclerosis as an infectious disease. Acta Neurologica Scandinavica Supplement 161: 34–42.CrossRefGoogle ScholarPubMed
Cornwell, HJ, Thompson, H, McCandlish, IA, Macartney, L and Nash, AS (1988). Encephalitis in dogs associated with a batch of canine distemper (Rockborn) vaccine. Veterinary Record 122: 54–59.CrossRefGoogle ScholarPubMed
Dal Canto, MC and Rabinowitz, SG (1982). Experimental models of virus-induced demyelination of the central nervous system. Annals of Neurology 11: 109–127.CrossRefGoogle ScholarPubMed
Daszak, P, Cunningham, AA and Hyatt, AD (2000). Emerging infectious diseases of wildlife-threats to biodiversity and human health. Science 287: 443–449.CrossRefGoogle ScholarPubMed
Deem, SL, Spelman,, LH, Yates, RA and Montali, RJ (2000). Canine distemper in terrestrial carnivores: a review. Journal of Zoo and Wildlife Medicine 31: 441–451.Google ScholarPubMed
De Keyser, J, Wilczak, N, Walter, JH and Zurbriggen, A (2001). Disappearance of beta2-adrenergic receptors on astrocytes in canine distemper encephalitis: possible implications for the pathogenesis of multiple sclerosis. Neuroreport 12: 191–194.CrossRefGoogle ScholarPubMed
Domingo, E and Holland, JJ (1994). Mutation rates and rapid evolution of RNA viruses. In: Morse, SS (editor). The Evolutionary Biology of Viruses. New York: Raven Press: pp. 151–184.Google Scholar
Duignan, PJ, Saliki, JT, St Aubin, DJ, Early, G, Sadove, S, House, JA, Kovacs, K and Geraci, JR (1995). Epizootiology of morbillivirus infection in North American harbor seals (Phoca vitulina) and gray seals (Halichoerus grypus). Journal of Wildlife Diseases 31: 491–501.CrossRefGoogle ScholarPubMed
Ek-Kommonen, C, Sihvonen, L, Pekkanen, K, Rikula, U and Nuotio, L (1997). Outbreak of canine distemper in vaccinated dogs in Finland. Veterinary Record 141: 380–383.CrossRefGoogle ScholarPubMed
Gemma, T, Watari, T, Akiyama, K, Miyashita, N, Shin, YS, Iwatsuki, K, Kai, C and Mikami, T (1996). Epidemiological observations on recent outbreaks of canine distemper in Tokyo area. Journal of Veterinary Medical Science 58: 547–550.CrossRefGoogle ScholarPubMed
Gilden, DH (2002). A search for virus in multiple sclerosis. Hybridoma and Hybridomics 21: 93–97.CrossRefGoogle ScholarPubMed
Glaus, T, Griot, C, Richard, A, Althaus, U, Herschkowitz, N and Vandevelde, M (1990). Ultrastructural and biochemical findings in brain cell cultures infected with canine distemper virus. Acta Neuropathologica (Berlin) 80: 59–67.CrossRefGoogle ScholarPubMed
Graber, H, Müller, C, Vandevelde, M and Zurbriggen, A (1995). Restricted infection with canine distemper virus leads to down-regulation of myelin gene transcription in cultured oligodendrocytes. Acta Neuropathologica (Berlin) 90: 312–318.CrossRefGoogle ScholarPubMed
Griot, C and Vandevelde, M (1988). Transferrin, carbonic anhydrase C and ferritin in dissociated murine brain cell cultures. Journal of Neuroimmunology 18: 333–340.CrossRefGoogle ScholarPubMed
Griot, C, Bürge, T, Vandevelde, M and Peterhans, E (1989 a). Antibody-induced generation of reactive oxygen radicals by brain macrophages in canine distemper encephalitis: a mechanism for bystander demyelination. Acta Neuropathologica 78: 396–403.CrossRefGoogle ScholarPubMed
Griot, C, Bürge, T, Vandevelde, M and Peterhans, E (1989 b). Bystander demyelination through antibody induced macrophage activation in canine distemper virus infection. Schweizer Archiv für Neurologie, Neurochirurgie und Psychiatrie 140: 39–41.Google ScholarPubMed
Griot, C, Vandevelde, M, Richard, A, Peterhans, E and Stocker, R (1990). Selective degeneration of oligodendrocytes mediated by reactive oxygen species. Free Radical Research Communications 11: 181–193.CrossRefGoogle ScholarPubMed
Griot-Wenk, M, Griot, C, Pfister, H and Vandevelde, M (1991). Antibody-dependent cellular cytotoxicity in anti-myelin antibody-induced oligodendrocyte damage in vitro. Journal of Neuroimmunology 33: 145–155.CrossRefGoogle Scholar
Harcourt, BH, Tamin, A, Ksiazek, TG, Rollin, PE, Anderson, LJ, Bellini, WJ and Rota, PA (2000). Molecular characterization of Nipah virus, a newly emergent paramyxovirus. Virology 271: 334–349.CrossRefGoogle ScholarPubMed
Harder, TC, Kenter, M, Appel, MJG, Roelke-Parker, ME, Barrett, T & Osterhaus, ADME (1995). Phylogenetic evidence of canine distemper virus in Serengeti's lions. Vaccine 13: 521–523.CrossRefGoogle ScholarPubMed
Hartley, WJ. (1974). A post-vaccinal inclusion body encephalitis in dogs. Veterinary Pathology 11: 301–312.CrossRefGoogle ScholarPubMed
Higgins, RJ, Krakowka, SG, Metzler, A and Koestner, A (1982). Primary demyelination in experimental canine distemper virus induced encephalomyelitis in gnotobiotic dogs. Sequential immunologic and morphologic findings. Acta Neuropathologica 58: 1–8.CrossRefGoogle ScholarPubMed
Hooper, PT and Williamson, MM (2000). Hendra and Nipah virus infections. Emerging Infectious Diseases 16: 597–603.Google ScholarPubMed
Hughes, RA, Russell, WC, Froude, JR and Jarrett, RJ (1980). Pet ownership, distemper antibodies and multiple sclerosis. Journal of the Neurological Sciences 47: 429–432.CrossRefGoogle ScholarPubMed
Ikeda, Y, Nakamura, K, Miyazawa, T, Chen, MC, Kuo, TF, Lin, JA, Mikami, T, Kai, C and Takahashi, E (2001). Seroprevalence of canine distemper virus in cats. Clinical and Diagnostic Laboratory Immunology 8: 641–644.CrossRefGoogle ScholarPubMed
Jensen, T, van de Bildt, M, Dietz, HH, Andersen, TH, Hammer, AS, Kuiken, T and Osterhaus, A (2002). Another phocine distemper outbreak in Europe. Science 297: 209.CrossRefGoogle ScholarPubMed
Iwatsuki, K, Miyashita, N, Yoshida, E, Gemma, T, Shin, YS, Mori, T, Hirayama, N, Kai, C and Mikami, T (1997). Molecular and phylogenetic analyses of the haemagglutinin (H) proteins of field isolates of canine distemper virus from naturally infected dogs. Journal of General Virology 78: 373–380.CrossRefGoogle ScholarPubMed
Johnson, GC, Fenner, WR and Krakowka, S (1988). Production of immunoglobulin G and increased antiviral antibody in cerebrospinal fluid of dogs with delayed-onset canine distemper viral encephalitis. Journal of Neuroimmunology 17: 237–251.CrossRefGoogle ScholarPubMed
Johnson, R, Glickman, LT, Emerick, TJ and Patronek, GJ (1995). Canine distemper infection in pet dogs: I. Surveillance in Indiana during a suspected outbreak. Journal of the American Animal Hospital Association 31: 223–229.CrossRefGoogle ScholarPubMed
Kennedy, S, Kuiken, T, Jepson, PD, Deaville, R, Forsyth, M, Barrett, T, van de Bildt, MWG, Osterhaus, ADME, Eybatov, T, Duck, C, Kydyrmanov, A, Mitrofanov, I and Wilson, S (2000). Mass die-off of Caspian seals caused by canine distemper virus. Emerging Infectious Diseases 6: 637–639.CrossRefGoogle ScholarPubMed
Krakowka, S (1982). Mechanisms of in vitro immunosuppression in canine distemper virus infection. Journal of Clinical and Laboratory Immunology 8: 187–196.Google ScholarPubMed
Krakowka, S and Koestner, A (1978). Canine distemper virus and multiple sclerosis. Lancet 1: 1127–1128.CrossRefGoogle ScholarPubMed
Krakowka, S, McCullough, B, Koestner, A and Olsen, R (1973). Myelin-specific auto-antibodies associated with central nervous system demyelination in canine distemper virus infection. Infection and Immunity 8: 819–827.CrossRefGoogle Scholar
Krakowka, S, Higgins, RJ and Koestner, A (1980). Canine distemper virus: review of structural and functional modulations in lymphoid tissues. American Journal of Veterinary Research 41: 284–292.Google ScholarPubMed
Lam, SK and Chua, KB (2002). Nipah virus encephalitis outbreak in Malaysia. Clinical Infectious Diseases 34: 48–51.CrossRefGoogle ScholarPubMed
Leisewitz, AL, Carter, A, van Vuuren, M and van Blerk, L (2001). Canine distemper infections, with special reference to South Africa, with a review of the literature. Journal of the South African Veterinary Association 72: 127–136.CrossRefGoogle ScholarPubMed
Mackenzie, JS, Chua, KB, Daniels, PW, Eaton, BT, Field, HE, Hall, RA, Pin, K, Johansen, CA, Kirkland, PD, Lam, SK, McMinn, P, Nisbet, DJ, Paru, R, Pyke, AT, Ritchie, SA, Siba, P, Smith, DW, Smith, GA, van den Hurk, AF, Wang, LF and Williams, DT (2001). Emerging viral diseases of Southeast Asia and the Western Pacific. Emerging Infectious Diseases 7: 497–504.CrossRefGoogle ScholarPubMed
Madden, DL, Wallen, WC, Houff, SA, Shekarchi, IC, Leinikki, PO, Castellano, GA and Sever, JL (1981). Measles and canine distemper antibody. Presence in sera from patients with multiple sclerosis and matched control subjects. Archives of Neurology 38: 13–15.CrossRefGoogle ScholarPubMed
Mayo, MA (2002). Virus taxonomy—Houston 2002. Archives of Virology 147: 1071–1076.Google ScholarPubMed
McCullough, B, Krakowka, S and Koestner, A (1974). Experimental canine distemper virus-induced demyelination. Laboratory Investigation 31: 216–222.Google ScholarPubMed
Morell, V (1996). New virus variant killed Serengeti cats. Science 271: 596.CrossRefGoogle ScholarPubMed
Müller, C, Fatzer, R, Beck, K, Vandevelde, M and Zurbriggen, A (1995). Studies on canine distemper virus persistence in the nervous system. Acta Neuropathologica (Berlin) 89: 438–445.CrossRefGoogle Scholar
Murray, PK, Selleck, P, Hooper, P, Hyatt, A, Gould, A, Gleeson, L, Westbury, H, Hiley, L, Selvey, L, Rodwell, B and Ketterer, P (1995). A morbillivirus that caused fatal disease in horses and humans. Science 268: 94–97.CrossRefGoogle ScholarPubMed
Murray, PK, Eaton, B, Hooper, P, Wang, L, Williamson, M and Young, P (1998). Flying foxes, horses and humans: a zoonosis caused by a new member of the Paramyxoviridae. In: Scheld, WM, Armstrong, O and Hughes, JM (editors). Emerging Infections 1. Washington, DC: ASM Press, pp.43–58.Google Scholar
Mutinelli, F, Vandevelde, M, Griot, C and Richard, A (1989). Astrocytic infection in canine distemper virus-induced demyelination. Acta Neuropathologica (Berlin) 77: 333–335.CrossRefGoogle ScholarPubMed
Olson, JG, Rupprecht, C, Rollin, PE, An, US, Niezgoda, M, Clemins, T, Walston, J and Ksiazek, TG (2002). Antibodies to Nipah-like virus in bats (Pteropus lylei), Cambodia. Emerging Infectious Diseases 8: 987–988.CrossRefGoogle ScholarPubMed
Osterhaus, ADME (2001). Catastrophes after crossing species barriers. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 356: 791–793.CrossRefGoogle ScholarPubMed
Osterhaus, ADME and Vedder, EJ (1988). Identification of virus causing recent seal deaths. Nature 335: 20.CrossRefGoogle ScholarPubMed
Osterhaus, ADME, Groen, J, De Vries, P, Uytdehaag, FGCM, Klingeborn, B and Zarnke, R (1988). Canine distemper virus in seals [letter]. Nature 335: 403–404.CrossRefGoogle ScholarPubMed
Osterhaus, ADME, Groen, J, UytdeHaag, FGCM, Visser, IKG, van de Bildt, MWG, Bergman, A and Klingeborn, B (1989). Distemper virus in Baikal seals. Nature 338: 209–210.CrossRefGoogle Scholar
O'Sullivan, JD, Allworth, AM, Paterson, DL, Snow, TM, Boots, R, Gleeson, LJ, Gould, AR, Hyatt, AD and Bradfield, J (1997). Fatal encephalitis due to novel paramyxovirus transmitted from horses. Lancet 349: 93–95.CrossRefGoogle ScholarPubMed
Raine, CS (1976). On the development of CNS lesions in natural canine distemper encephalomyelitis. Journal of the Neurological Sciences 30: 13–28.CrossRefGoogle ScholarPubMed
Roelke-Parker, ME, Munson, L, Packer, C, Kock, R, Cleaveland, S, Carpenter, M, O'Brien, SJ, Pospischil, A, Hofmann-Lehmann, R, Lutz, H, Mwamengele, GLM, Mgasa, MN, Machange, GA, Summers, BA and Appel, MJG (1996). A canine distemper virus epidemic in Serengeti lions (Panthera leo). Nature 379: 441–445.CrossRefGoogle ScholarPubMed
Rogers, RJJ, Douglas, IC, Baldock, FC, Glanville, RJ, Seppanen, KT, Gleeson, LJ, Selleck, PN and Dunn, KJ (1996). Investigation of a second focus of equine morbillivirus infection in coastal Queensland. Australian Veterinary Journal 74: 243–244.CrossRefGoogle ScholarPubMed
Rohowsky-Kochan, C, Dowling, PC and Cook, SD (1995). Canine distemper virus-specific antibodies in multiple sclerosis. Neurology 45: 1554–1560.CrossRefGoogle ScholarPubMed
Schobesberger, M, Zurbriggen, A, Summerfield, A, Vandevelde, M and Griot, C (1999). Oligodendroglial degeneration in distemper: apoptosis or necrosis? Acta Neuropathologica (Berlin) 97: 179–187.CrossRefGoogle ScholarPubMed
Schobesberger, M, Zurbriggen, A, Doherr, MG, Weissenböck, H, Vandevelde, M, Lassmann, H and Griot, C (2002). Demyelination precedes oligodendrocyte loss in canine distemper virus-induced encephalitis. Acta Neuropathologica (Berlin) 103: 11–19.CrossRefGoogle ScholarPubMed
Stettler, M and Zurbriggen, A (1995). Nucleotide and deduced amino acid sequences of the nucleocapsid protein of the virulent A75/17-CDV strain of canine distemper virus. Veterinary Microbiology 44: 211–217.CrossRefGoogle ScholarPubMed
Stettler, M, Beck, K, Wagner, A, Vandevelde, M and Zurbriggen, A (1997). Determinants of persistence in canine distemper viruses. Veterinary Microbiology 57: 83–89.CrossRefGoogle ScholarPubMed
Summers, BA and Appel, MJ (1987). Demyelination in canine distemper encephalomyelitis: an ultrastructural analysis. Journal of Neurocytology 16: 871–881.CrossRefGoogle ScholarPubMed
Summers, BA, Greisen, HA and Appel, MJ (1979). Early events in canine distemper demyelinating encephalomyelitis. Acta Neuropathologica (Berlin) 46: 1–10.CrossRefGoogle ScholarPubMed
Summers, BA, Greisen, HA and Appel, MJ (1984 a). Canine distemper encephalomyelitis: variation with virus strain. Journal of Comparative Pathology 94: 65–75.CrossRefGoogle ScholarPubMed
Summers, BA, Greisen, HA and Appel, MJ (1984 b). Canine distemper and experimental allergic encephalomyelitis in the dog: comparative patterns of demyelination. Journal of Comparative Pathology 94: 575–589.CrossRefGoogle ScholarPubMed
Summers, BA, Cummings, JF and deLahunta, A (1995). Canine distemper. In:. In. Veterinary Neuropathology St Louis: Mosby, pp. 102–110.Google Scholar
Tipold, A, Jaggy, A, Zurbriggen, A and Vandevelde, M (1996). Neurological signs in canine distemper encephalomyelitis—a clinical study. European Journal of Companion Animal Practice 6: 33–38.Google Scholar
Tipold, A, Moore, P, Zurbriggen, A, Burgener, I, Barben, G and Vandevelde, M (1999). Early T-cell response in the central nervous system in canine distemper virus infection. Acta Neuropathologica (Berlin) 97: 45–56.CrossRefGoogle ScholarPubMed
Van de Bildt, MWG, Kuiken, T, Visee, AM, Lema, S, Fitzjohn, TR and Osterhaus, ADME (2002). Distemper outbreak and its effect on African wild dog conservation. Emerging Infectious Diseases 8: 211–213.CrossRefGoogle ScholarPubMed
Vandevelde, M and Zurbriggen, A (1995). The neurobiology of canine distemper virus infection. Veterinary Microbiology 44: 271–280.CrossRefGoogle ScholarPubMed
Vandevelde, M, Fankhauser, R, Kristensen, F and Kristensen, B (1981). Immunoglobulins in demyelinating lesions in canine distemper encephalitis. An immunohistological study. Acta Neuropathologica (Berlin) 54: 31–41.CrossRefGoogle ScholarPubMed
Vandevelde, M, Higgins, RJ, Kristensen, B, Kristensen, F, Steck, AJ and Kihm, U (1982). Demyelination in experimental canine distemper virus infection: immunological, pathologic, and immunohistological studies. Acta Neuropathologica (Berlin) 56: 285–293.CrossRefGoogle ScholarPubMed
Vandevelde, M, Kristensen, F, Kristensen, B, Steck, AJ and Kihm, U (1982). Immunological and pathological findings in demyelinating encephalitis associated with canine distemper virus infection. Acta Neuropathologica (Berlin) 56: 1–8.CrossRefGoogle ScholarPubMed
Vandevelde, M, Zurbriggen, A, Dumas, M and Palmer, D (1985). Canine distemper virus does not infect oligodendrocytes in vitro. Journal of the Neurological Sciences 69: 133–137.CrossRefGoogle Scholar
Vandevelde, M, Zurbriggen, A, Higgins, RJ and Palmer, D (1985). Spread and distribution of viral antigen in nervous canine distemper. Acta Neuropathologica (Berlin) 67: 211–218.CrossRefGoogle ScholarPubMed
Vandevelde, M, Zurbriggen, A, Steck, A and Bichsel, P (1986). Studies on the intrathecal humoral immune response in canine distemper encephalitis. Journal of Neuroimmunology 11: 41–51.CrossRefGoogle ScholarPubMed
Wang, LF and Eaton, BT (2001). Emerging paramyxoviruses. Infectious Disease Review 3: 52–69.Google Scholar
Wang, LF, Yu, M, Hansson, E, Pritchard, LI, Shiell, B, Michalski, WP and Eaton, BT (2000). The exceptionally large genome of Hendra virus: support for creation of a new genus within the family Paramyxoviridae. Journal of Virology 4: 9972–9979.CrossRefGoogle Scholar
Wisniewski, H, Raine, CS and Kay, WJ (1972). Observations on viral demyelinating encephalomyelitis. Canine distemper. Laboratory Investigation 26: 589–599.Google ScholarPubMed
Wunschmann, A, Alldinger, S, Kremmer, E and Baumgärtner, W (1999). Identification of CD4+ and CD8+ T cell subsets and B cells in the brain of dogs with spontaneous acute, subacute-, and chronic-demyelinating distemper encephalitis. Veterinary Immunology and Immunopathology 67: 101–116.CrossRefGoogle Scholar
Zurbriggen, A, Vandevelde, M and Dumas, M (1986). Secondary degeneration of oligodendrocytes in canine distemper virus infection in vitro. Laboratory Investigation 54: 424–431.Google ScholarPubMed
Zurbriggen, A, Vandevelde, M, Dumas, M, Griot, C and Bollo, E (1987). Oligodendroglial pathology in canine distemper virus infection in vitro. Acta Neuropathologica (Berlin) 74: 366–373.CrossRefGoogle ScholarPubMed
Zurbriggen, A, Yamawaki, M and Vandevelde, M (1993). Restricted canine distemper virus infection of oligodendrocytes. Laboratory Investigation 68: 277–284.Google ScholarPubMed
Zurbriggen, A, Graber, H, Wagner, A and Vandevelde, M (1995). Canine distemper persistence in the nervous system is associated with non-cytolytic virus spread. Journal of Virology 69: 1678–1686.CrossRefGoogle Scholar
Zurbriggen, A, Schmid, I, Graber, HU and Vandevelde, M (1998). Oligodendroglial pathology in canine distemper. Acta Neuropathologica (Berlin) 95: 71–77.CrossRefGoogle ScholarPubMed