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Porcine circovirus diseases

  • Joaquim Segalés (a1), Gordon M. Allan (a2) and Mariano Domingo (a1)
  • DOI: http://dx.doi.org/10.1079/AHR2005106
  • Published online: 01 March 2007
Abstract
Abstract

Porcine circovirus type 2 (PCV2) is a member of the family Circoviridae, a recently established virus family composed of small, non-enveloped viruses, with a circular, single-stranded DNA genome. PCV2, which is found all over the world in the domestic pig and probably the wild boar, has been recently associated with a number of disease syndromes, which have been collectively named porcine circovirus diseases (PCVD). Postweaning multisystemic wasting syndrome (PMWS), porcine dermatitis and nephropathy syndrome (PDNS) and reproductive disorders are the most relevant ones. Among them, only PMWS is considered to have a severe impact on domestic swine production. PMWS mainly affects nursery and/or fattening pigs; wasting is considered the most representative clinical sign in this disease. Diagnosis of this disease is confirmed by histopathological examination of lymphoid tissues and detection of a moderate to high amount of PCV2 in damaged tissues. Since PMWS is considered a multifactorial disease in which other factors in addition to PCV2 are needed in most cases to trigger the clinical disease, effective control measures have focused on the understanding of the co-factors involved in individual farms and the control or elimination of these triggers. PDNS, an immuno-complex disease characterized by fibrino-necrotizing glomerulonephritis and systemic necrotizing vasculitis, has been linked to PCV2, but a definitive proof of this association is still lacking. PCV2-associated reproductive disease seems to occur very sporadically under field conditions, but it has been characterized by late-term abortions and stillbirths, extensive fibrosing and/or necrotizing myocarditis in fetuses and the presence of moderate to high amounts of PCV2 in these lesions. Taking into account that scientific information on PCV2 and its associated diseases has been markedly expanded in the last 8 years, the objective of this review is to summarize the current state of knowledge of the most relevant aspects of PCV2 biology and PCVD.

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*Corresponding author: Email: joaquim.segales@uab.es
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E Albina , C Truong , E Hutet , P Blanchard , R Cariolet , R L'Hospitalier , D Mahe , C Allee , H Morvan , N Amenna , M Le Dimna , F Madec and A Jestin (2001). An experimental model for post-weaning multisystemic wasting syndrome (PMWS) in growing piglets. Journal of Comparative Pathology 125: 292303.

GM Allan and JA Ellis (2000). Porcine circoviruses: a review. Journal of Veterinary Diagnostic Investigation 12: 314.

GM Allan , K Phenix , D Todd and M McNulty (1994). Some biological and physico-chemical properties or porcine circovirus. Journal of Veterinary Medicine B 41: 1726.

GM Allan , F McNeilly , JP Cassidy , GAC Reilly , BM Adair , WA Ellis and MS McNulty (1995). Pathogenesis of porcine circovirus: experimental infections of colostrum deprived piglets and examination of pig foetal material. Veterinary Microbiology 44: 4964.

GM Allan , F McNeilly , S Kennedy , B Daft , EG Clarke , JA Ellis , DM Haines , BM Meehan and BM Adair (1998). Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe. Journal of Veterinary Diagnostic Investigation 10: 310.

GM Allan , S Kennedy , F McNeilly , JC Foster , JA Ellis , SJ Krakowka , BM Meehan and BM Adair (1999a). Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus. Journal of Comparative Pathology 121: 111.

GM Allan , F McNeilly , BM Meehan , S Kennedy , DP Mackie , JA Ellis , EG Clark , E Espuña , N Saubi , P Riera , A Botner and CE Charreyre (1999b). Isolation and characterisation of circoviruses from pigs with wasting syndromes in Spain, Denmark and Northern Ireland. Veterinary Microbiology 66: 115123.

GM Allan , F McNeilly , I McNair , MD Curran , I Walker , J Ellis , C Konoby , S Kennedy and B Meehan (2000b). Absence of evidence for porcine circovirus type 2 in cattle and humans, and lack of seroconversion or lesions in experimentally infected sheep. Archives of Virology 145: 853857.

G Allan , F McNeilly , B Meehan , I McNair , J Ellis , S Krakowka , C Fossum , E Wattrang , P Wallgren and B Adair (2003). Reproduction of postweaning multisystemic wasting syndrome in pigs experimentally inoculated with a Swedish porcine circovirus 2 isolate. Journal of Veterinary Diagnostic Investigation 15: 553560.

M Balasch , J Segalés , C Rosell , M Domingo , A Mankertz , A Urniza and J Plana-Durán (1999). Experimental inoculation of conventional pigs with tissue homogenates from pigs with post-weaning multisystemic wasting syndrome. Journal of Comparative Pathology 121: 139148.

P Blanchard , D Mahe , R Cariolet , A Keranflec'h , MA Baudouard , P Cordioli , E Albina and A Jestin (2003a). Protection of swine against post-weaning multisystemic wasting syndrome (PMWS) by porcine circovirus type 2 (PCV2) proteins. Vaccine 21: 45654575.

P Blanchard , D Mahe , R Cariolet , C Truong , M Le Dimna , C Arnauld , N Rose , E Eveno , E Albina , F Madec and A Jestin (2003b). An ORF2 protein-based ELISA for porcine circovirus type 2 antibodies in post-weaning multisystemic wasting syndrome. Veterinary Microbiology 94: 183194.

SR Bolin , WC Stoffregen , GP Nayar and AL Hamel (2001). Postweaning multisystemic wasting syndrome induced after experimental inoculation of cesarean-derived, colostrum-deprived piglets with type 2 porcine circovirus. Journal of Veterinary Diagnostic Investigation 13: 185194.

M Calsamiglia , J Segalés , J Quintana , C Rosell and M Domingo (2002). Detection of porcine circovirus types 1 and 2 in serum and tissue samples of pigs with and without postweaning multisystemic wasting syndrome. Journal of Clinical Microbiology 40: 18481850.

L Carrasco , J Segalés , MJ Bautista , JC Gómez-Villamandos , C Rosell , E Ruiz-Villamor and MA Sierra (2000). Intestinal chlamydial infection concurrent with postweaning multisystemic wasting syndrome in pigs. Veterinary Record 146: 2123.

AK Cheung (2003). The essential and nonessential transcription units for viral protein synthesis and DNA replication of porcine circovirus type 2. Virology 313: 452459.

AK Cheung and SR Bolin (2002). Kinetics of porcine circovirus type 2 replication. Archives of Virology 147: 4358.

F Chianini , N Majó , J Segalés , J Domínguez and M Domingo (2003). Immunohistochemical characterisation of PCV2 associate lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS) Veterinary Immunology and Immunopathology 94: 6375.

C Choi and C Chae (2002). Colocalization of porcine reproductive and respiratory syndrome virus and porcine circovirus 2 in porcine dermatitis and nephrology syndrome by double-labeling technique. Veterinary Pathology 38: 436441.

L Darwich , J Segalés , M Domingo and E Mateu (2002). Changes in CD4(+), CD8(+), CD4(+) CD8(+), and immunoglobulin M-positive peripheral blood mononuclear cells of postweaning multisystemic wasting syndrome-affected pigs and age-matched uninfected wasted and healthy pigs correlate with lesions and porcine circovirus type 2 load in lymphoid tissues. Clinical and Diagnostic Laboratorial Immunology 9: 236242.

L Darwich , M Balasch , J Plana-Duran , J Segalés , M Domingo and E Mateu (2003a). Cytokine profiles of peripheral blood mononuclear cells from pigs with postweaning multisystemic wasting syndrome in response to mitogen, superantigen or recall viral antigens. Journal of General Virology 84: 34533457.

L Darwich , S Pie , A Rovira , J Segalés , M Domingo , IP Oswald and E Mateu (2003b). Cytokine mRNA expression profiles in lymphoid tissues of pigs naturally affected by postweaning multisystemic wasting syndrome. Journal of General Virology 84: 21172125.

L Darwich , J Segalés and E Mateu (2004). Pathogenesis of postweaning multisystemic wasting syndrome caused by porcine circovirus 2: an immune riddle. Archives of Virology 149: 857874.

C De Boisseson , V Beven , L Bigarre , R Thiery , N Rose , E Eveno , F Madec and A Jestin (2004). Molecular characterization of porcine circovirus type 2 isolates from post-weaning multisystemic wasting syndrome-affected and non-affected pigs. Journal of General Virology 85: 293304.

R Drolet , R Larochelle , M Morin , B Delisle and R Magar (2003). Detection rates of porcine reproductive and respiratory syndrome virus, porcine circovirus type 2, and swine influenza virus in porcine proliferative and necrotizing pneumonia. Veterinary Pathology 40: 143148.

S Edwards and J Sands (1994). Evidence of porcine circovirus infection in British pigs. Veterinary Record 134: 680681.

J Ellis , S Krakowka , M Lairmore , D Haines , A Bratanich , E Clark , G Allan , C Konoby , L Hassard , B Meehan , K Martin , J Harding , S Kennedy and F McNeilly (1999). Reproduction of lesions of postweaning multisystemic wasting syndrome in gnotobiotic piglets. Journal of Veterinary Diagnostic Investigation 11: 314.

JA Ellis , BM Wiseman , G Allan , C Konoby , S Krakowka , BM Meehan and F McNeilly (2000). Analysis of seroconversion to porcine circovirus 2 among veterinarians from the United States and Canada. Journal of the American Veterinary Medical Association 217: 16451646.

J Ellis , M Spinato , C Yong , K West , F McNeilly , B Meehan , S Kennedy , E Clark , S Krakowka and G Allan (2003). Porcine circovirus 2-associated disease in Eurasian wild boar. Journal of Veterinary Diagnostic Investigation 15: 364368.

J Ellis , E Clark , D Haines , K West , S Krakowka , S Kennedy and GM Allan (2004). Porcine circovirus-2 and concurrent infections in the field. Veterinary Microbiology 98: 159163.

M Fenaux , PG Halbur , G Haqshenas , R Royer , P Thomas , P Nawagitgul , M Gill , TE Toth and XJ Meng (2002). Cloned genomic DNA of type 2 porcine circovirus is infectious when injected directly into the liver and lymph nodes of pigs: characterization of clinical disease, virus distribution, and pathologic lesions. Journal of Virology 76: 541551.

M Fenaux , T Opriessnig , PG Halbur and XJ Meng (2003). Immunogenicity and pathogenicity of chimeric infectious DNA clones of pathogenic porcine circovirus type 2 (PCV2) and nonpathogenic PCV1 in weaning pigs. Journal of Virology 77: 1123211243.

M Fenaux , T Opriessnig , PG Halbur , F Elvinger and XJ Meng (2004a). A chimeric porcine circovirus (PCV) with the immunogenic capsid gene of the pathogenic PCV type 2 (PCV2) cloned into the genomic backbone of the nonpathogenic PCV1 induces protective immunity against PCV2 infection in pigs. Journal of Virology 78: 62976303.

M Fenaux , T Opriessnig , PG Halbur , F Elvinger and XJ Meng (2004b). Two amino acid mutations in the capsid protein of type 2 porcine circovirus (PCV2) enhanced PCV2 replication in vitro and attenuated the virus in vivo. Journal of Virology 78: 1344013446.

DF Gilpin , K McCullough , BM Meehan , F McNeilly , I McNair , LS Stevenson , JC Foster , JA Ellis , S Krakowka , BM Adair and GM Allan (2003). In vitro studies on the infection and replication of porcine circovirus type 2 in cells of the porcine immune system. Veterinary Immunology and Immunopathology 94: 149161.

SS Grierson , DP King , T Sandvik , D Hicks , Y Spencer , TW Drew and M Banks (2004). Detection and genetic typing of type 2 porcine circoviruses in archived pig tissues from the UK. Archives of Virology 149: 11711183.

Y Ha and C Chae (2005). Lack of evidence of porcine circovirus type 1 and type 2 infection in piglets with congenital tremors in Korea. Veterinary Record 156: 383384.

PA Harms , SD Sorden , PG Halbur , S Bolin , K Lager , I Morozov and PS Paul (2001). Experimental reproduction of severe disease in CD/CD pigs concurrently infected with type 2 porcine circovirus and PRRSV. Veterinary Pathology 38: 528539.

FC Hasslung , M Berg , GM Allan , BM Meehan , F McNeilly and C Fossum (2003). Identification of a sequence from the genome of porcine circovirus type 2 with an inhibitory effect on IFN-alpha production by porcine PBMCs. Journal of General Virology 84: 29372945.

F Hasslung , P Wallgren , AS Ladekjaer-Mikkelsen , A Botner , J Nielsen , E Wattrang , GM Allan , F McNeilly , J Ellis , S Timmusk , K Belak , T Segall , L Meilin , M Berg and C Fossum (2005). Experimental reproduction of postweaning multisystemic wasting syndrome (PMWS) in pigs in Sweden and Denmark with a Swedish isolate of porcine circovirus type 2. Veterinary Microbiology 106: 4960.

T Hirai , T Nunoya , T Ihara , K Kusanagi and K Shibuya (2001). Dual infection with PCV-2 and porcine epidemic diarrhoea virus in neonatal piglets. Veterinary Record 148: 482484.

CS Johnson , HS Joo , K Direksin , KJ Yoon and YK Choi (2002). Experimental in utero inoculation of late-term swine fetuses with porcine circovirus type 2. Journal of Veterinary Diagnostic Investigation 14: 507512.

S Kennedy , D Moffett , F McNeilly , B Meehan , J Ellis , S Krakowka and GM Allan (2000). Reproduction of lesions of postweaning multisystemic wasting syndrome by infection of conventional pigs with porcine circovirus type 2 alone or in combination with porcine parvovirus. Journal of Comparative Pathology 122: 924.

S Kennedy , J Segalés , A Rovira , S Scholes , M Domingo , D Moffett , B Meehan , R O'Neill , F McNeilly and G Allan (2003). Absence of evidence of porcine circovirus infection in piglets with congenital tremors. Journal of Veterinary Diagnostic Investigation 15: 151156.

J Kim and C Chae (2001). Optimized protocols for the detection of porcine circovirus 2 DNA from formalin-fixed paraffin-embedded tissues using nested polymerase chain reaction and comparison of nested PCR with in situ hybridization. Journal of Virological Methods 92: 105111.

J Kim , K Jung and C Chae (2004). Prevalence of porcine circovirus type 2 in aborted fetuses and stillborn piglets. Veterinary Record 155: 489492.

M Kiupel , GW Stevenson , J Choi , KS Latimer , CL Kanitz and SK Mittal (2001). Viral replication and lesions in BALB/c mice experimentally inoculated with porcine circovirus isolated from a pig with postweaning multisystemic wasting disease. Veterinary Pathology 38: 7482.

S Krakowka , JA Ellis , B Meehan , S Kennedy , F McNeilly and G Allan (2000). Viral wasting syndrome of swine: experimental reproduction of postweaning multisystemic wasting syndrome in gnotobiotic swine by coinfection with porcine circovirus 2 and porcine parvovirus. Veterinary Pathology 37: 254263.

S Krakowka , JA Ellis , F McNeilly , S Ringler , DM Rings and G Allan (2001). Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2). Veterinary Pathology 38: 3142.

SC Kyriakis , K Saoulidis , S Lekkas , CC Miliotis , PA Papoutsis and S Kennedy (2002). The effects of immuno-modulation on the clinical and pathological expression of postweaning multisystemic wasting syndrome. Journal of Comparative Pathology 126: 3846.

AS Ladekjaer-Mikkelsen , J Nielsen , T Stadejek , T Storgaard , S Krakowka , J Ellis , F McNeilly , G Allan and A Botner (2002). Reproduction of postweaning multisystemic wasting syndrome (PMWS) in immunostimulated and non-immunostimulated 3-week-old piglets experimentally infected with porcine circovirus type 2 (PCV2). Veterinary Microbiology 89: 97114.

FA Lainson , KD Aitchison , W Donachie and JR Thomson (2002). Typing of Pasteurella multocida isolated from pigs with and without porcine dermatitis and nephropathy syndrome. Journal of Clinical Microbiology 40: 588593.

R Larochelle , M Morin , M Antaya and R Magar (1999). Identification and incidence of porcine circovirus in routine field cases in Quebec as determined by PCR. Veterinary Record 145: 140142.

R Larochelle , R Magar and S D'Allaire (2002). Genetic characterization and phylogenetic analysis of porcine circovirus type 2 (PCV2) strains from cases presenting various clinical conditions. Virus Research 90: 101112.

P Lekcharoensuk , I Morozov , PS Paul , N Thangthumniyom , W Wajjawalku and XJ Meng (2004). Epitope mapping of the major capsid protein of type 2 porcine circovirus (PCV2) by using chimeric PCV1 and PCV2. Journal of Virology 78: 81358145.

J Liu , I Chen and J Kwang (2005). Characterization of a previously unidentified viral protein in porcine circovirus type 2 infected cells and its role in virus induced apoptosis. Journal of Virology 79: 82628274.

F Madec , E Eveno , P Morvan , L Hamon , P Blanchard , R Cariolet , N Amenna , H Morvan , C Truong , D Mahé , E Albina and A Jestin (2000). Post-weaning multisystemic wasting syndrome (PMWS) in pigs in France: clinical observations from follow-up studies on affected farms. Livestock Production Science 63: 223233.

R Magar , R Larochelle , S Thibault and L Lamontagne (2000). Experimental transmission of porcine circovirus type 2 (PCV2) in weaned pigs: a sequential study. Journal of Comparative Pathology 123: 258269.

J Maldonado , J Segalés , D Martinez-Puig , M Calsamiglia , P Riera , M Domingo and C Artigas (2005). Identification of viral pathogens in aborted fetuses and stillborn piglets from cases of swine reproductive failure in Spain. Veterinary Journal 169: 454456.

L Mandrioli , G Sarli , S Panarese , S Baldoni and PS Marcato (2004). Apoptosis and proliferative activity in lymph node reaction in postweaning multisystemic wasting syndrome (PMWS) Veterinary Immunology and Immunopathology 97: 2537.

A Mankertz , M Domingo , JM Folch , P LeCann , A Jestin , J Segalés , B Chmielewicz , J Plana-Duran and D Soike (2000). Characterisation of PCV-2 isolates from Spain, Germany and France. Virus Research 66: 6577.

A Mankertz , R Caliskan , K Hattermann , B Hillenbrand , P Kurzendoerfer , B Mueller , C Schmitt , T Steinfeldt and T Finsterbusch (2004). Molecular biology of porcine circovirus: analyses of gene expression and viral replication. Veterinary Microbiology 98: 8188.

B Mateusen , RE Sanchez , A Van Soom , P Meerts , DG Maes and HJ Nauwynck (2004). Susceptibility of pig embryos to porcine circovirus type 2 infection. Theriogenology 61: 91101.

F McNeilly , S Kennedy , D Moffett , BM Meehan , JC Foster , EG Clarke , JA Ellis , DM Haines , BM Adair and GM Allan (1999). A comparison of in situ hybridization and immunohistochemistry for the detection of a new porcine circovirus in formalin-fixed tissues from pigs with post-weaning multisystemic wasting syndrome (PMWS) Journal of Virological Methods 80: 123128.

F McNeilly , I McNair , DP Mackie , BM Meehan , S Kennedy , D Moffett , J Ellis , S Krakowka and GM Allan (2001). Production, characterisation and applications of monoclonal antibodies to porcine circovirus 2. Archives of Virology 146: 909922.

F McNeilly , I McNair , M O'Connor , S Brockbank , D Gilpin , C Lasagna , G Boriosi , B Meehan , J Ellis , S Krakowka and GM Allan (2002). Evaluation of a porcine circovirus type 2-specific antigen-capture enzyme-linked immunosorbent assay for the diagnosis of postweaning multisystemic wasting syndrome in pigs: comparison with virus isolation, immunohistochemistry, and the polymerase chain reaction. Journal of Veterinary Diagnostic Investigation 14: 106112.

I McNair , M Marshall , F McNeilly , A Botner , AS Ladekjaer-Mikkelsen , I Vincent , B Herrmann , R Sanchez and C Rhodes (2004). Interlaboratory testing of porcine sera for antibodies to porcine circovirus type 2. Journal of Veterinary Diagnostic Investigation 16: 164166.

BM Meehan , F McNeilly , D Todd , S Kennedy , VA Jewhurst , JA Ellis , LE Hassard , EG Clark , DM Haines and GM Allan (1998). Characterization of novel circovirus DNAs associated with wasting syndromes in pigs. Journal of General Virology 79: 21712179.

G Misinzo , P Meerts , M Bublot , J Mast , HM Weingartl and HJ Nauwynck (2005). Binding and entry characteristics of porcine circovirus 2 in cells of the porcine monocytic line 3D4/31. Journal of General Virology 86: 20572068.

M Mori , K Sato , S Akachi , S Asahi , S Taniguchi and M Narita (2000). Retrospective study of porcine circovirus 2 infection in Japan: seven cases in 1989. Veterinary Pathology 37: 667669.

J Nielsen , IE Vincent , A Botner , AS Ladekaer-Mikkelsen , G Allan , A Summerfield and KC McCullough (2003). Association of lymphopenia with porcine circovirus type 2 induced postweaning multisystemic wasting syndrome (PMWS) Veterinary Immunology and Immunopathology 92: 97111.

A Nunez , F McNeilly , A Perea , PJ Sanchez-Cordon , B Huerta , G Allan and L Carrasco (2003). Coinfection by Cryptosporidium parvum and porcine circovirus type 2 in weaned pigs. Journal of Veterinary Medicine B 50: 255258.

Y Okuda , M Ono , S Yazawa and I Shibata (2003). Experimental reproduction of postweaning multisystemic wasting syndrome in cesarean-derived, colostrum-deprived piglets inoculated with porcine circovirus type 2 (PCV2): investigation of quantitative PCV2 distribution and antibody responses. Journal of Veterinary Diagnostic Investigation 15: 107114.

A Olvera , M Sibila , M Calsamiglia , J Segalés and M Domingo (2004). Comparison of porcine circovirus type 2 load in serum quantified by a real time PCR in postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome naturally affected pigs. Journal of Virological Methods 117: 7580.

T Opriessnig , S Yu , JM Gallup , RB Evans , M Fenaux , F Pallares , EL Thacker , CW Brockus , MR Ackermann , P Thomas , XJ Meng and PG Halbur (2003). Effect of vaccination with selective bacterins on conventional pigs infected with type 2 porcine circovirus. Veterinary Pathology 40: 521529.

T Opriessnig , M Fenaux , S Yu , RB Evans , D Cavanaugh , JM Gallup , FJ Pallares , EL Thacker , KM Lager , XJ Meng and PG Halbur (2004b). Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus. Veterinary Microbiology 98: 209220.

F Ostanello , A Caprioli , A Di Francesco , M Battilani , G Sala , G Sarli , L Mandrioli , F McNeilly , GM Allan and S Prosperi (2005). Experimental infection of 3-week-old conventional colostrums-fed pigs with porcine circovirus type 2 and porcine parvovirus. Veterinary Microbiology 108: 179186.

FJ Pallares , PG Halbur , T Opriessnig , SD Sorden , D Villar , BH Janke , MJ Yaeger , DJ Larson , KJ Schwartz , KJ Yoon and LJ Hoffman (2002). Porcine circovirus type 2 (PCV-2) coinfections in US field cases of postweaning multisystemic wasting syndrome (PMWS) Journal of Veterinary Diagnostic Investigation 14: 515519.

JS Park , J Kim , Y Ha , K Jung , C Choi , JK Lim , SH Kim and C Chae (2005). Birth abnormalities in pregnant sows infected intranasally with porcine circovirus 2. Journal of Comparative Pathology 132: 139144.

MB Pensaert , RE Sanchez , AS Ladekjaer-Mikkelsen Jr, GM Allan and HJ Nauwynck (2004). Viremia and effect of fetal infection with porcine viruses with special reference to porcine circovirus 2 infection. Veterinary Microbiology 98: 175183.

RM Pogranichniy , KJ Yoon , PA Harms , SL Swenson , JJ Zimmerman and SD Sorden (2000). Characterization of immune response of young pigs to porcine circovirus type 2 infection. Viral Immunology 13: 143153.

RM Pogranichniy , KJ Yoon , PA Harms , SD Sorden and M Daniels (2002). Case-control study on the association of porcine circovirus type 2 and other swine viral pathogens with postweaning multisystemic wasting syndrome. Journal of Veterinary Diagnostic Investigation 14: 449456.

J Quintana , J Segalés , C Rosell , M Calsamiglia , GM Rodríguez-Arrioja , F Chianini , JM Folch , J Maldonado , M Canal , J Plana-Durán and M Domingo (2001). Clinical and pathological observations of pigs with postweaning multisystemic wasting syndrome. Veterinary Record 149: 357361.

J Quintana , M Balasch , J Segalés , M Calsamiglia , GM Rodriguez-Arrioja , J Plana-Duran and M Domingo (2002). Experimental inoculation of porcine circoviruses type 1 (PCV1) and type 2 (PCV2) in rabbits and mice. Veterinary Research 33: 229237.

AR Resendes , N Majo , J Segalés , E Mateu , M Calsamiglia and M Domingo (2004a). Apoptosis in lymphoid organs of pigs naturally infected by porcine circovirus type 2. Journal of General Virology 85: 28372844.

A Resendes , J Segalés , M Balasch , M Calsamiglia , M Sibila , H Ellerbrok , E Mateu , J Plana-Duran , A Mankertz and M Domingo (2004b). Lack of an effect of a commercial vaccine adjuvant on the development of postweaning multisystemic wasting syndrome (PMWS) in porcine circovirus type 2 (PCV2) experimentally infected conventional pigs. Veterinary Research 35: 8390.

M Roca , M Balasch , J Segalés , M Calsamiglia , E Viaplana , A Urniza , K Hattermann , A Mankertz , J Plana-Duran and M Domingo (2004). In vitro and in vivo characterization of an infectious clone of a European strain of porcine circovirus type 2. Journal of General Virology 85: 12591266.

GM Rodríguez-Arrioja , J Segalés , C Rosell , J Quintana , S Ayllón , A Camprodón and M Domingo (1999). Aujeszky's disease virus infection concurrent with postweaning multisystemic wasting syndrome in pigs. Veterinary Record 144: 152153.

GM Rodríguez-Arrioja , J Segalés , M Balasch , C Rosell , J Quintana , JM Folch , J Plana-Durán , A Mankertz and M Domingo (2000). Serum antibodies to porcine circovirus type 1 (PCV-1) and type 2 (PCV-2) in pigs with and without postweaning multisystemic wasting syndrome (PMWS) Veterinary Record 146: 762764.

GM Rodriguez-Arrioja , J Segalés , M Calsamiglia , AR Resendes , M Balasch , J Plana-Duran , J Casal and M Domingo (2002). Dynamics of porcine circovirus type 2 infection in a herd of pigs with postweaning multisystemic wasting syndrome. American Journal of Veterinary Research 63: 354357.

GM Rodriguez-Arrioja , J Segalés , C Rosell , A Rovira , J Pujols , J Plana-Duran and M Domingo (2003b). Retrospective study on porcine circovirus type 2 infection in pigs from 1985 to 1997 in Spain. Journal of Veterinary Medicine B 50: 99101.

N Rose , G Larour , G Le Diguerher , E Eveno , JP Jolly , P Blanchard , A Oger , M Le Dimna , A Jestin and F Madec (2003b). Risk factors for porcine post-weaning multisystemic wasting syndrome (PMWS) in 149 French farrow-to-finish herds. Preventive Veterinary Medicine 61: 209225.

C Rosell , J Segalés , J Plana-Durán , M Balasch , GM Rodríguez-Arrioja , S Kennedy , GM Allan , F McNeilly , KS Latimer and M Domingo (1999). Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. Journal of Comparative Pathology 120: 5978.

C Rosell , J Segalés and M Domingo (2000a). Hepatitis and staging of hepatic damage in pigs naturally infected with porcine circovirus type 2. Veterinary Pathology 37: 687692.

C Rosell , J Segalés , JA Ramos-Vara , JM Folch , GM Rodríguez-Arrioja , CO Duran , M Balasch , J Plana-Durán and M Domingo (2000b). Identification of porcine circovirus in tissues of pigs with porcine dermatitis and nephropathy syndrome. Veterinary Record 146: 4043.

A Rovira , M Balasch , J Segalés , L Garcia , J Plana-Duran , C Rosell , H Ellerbrock , A Mankertz and M Domingo (2002). Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome virus and porcine circovirus 2. Journal of Virology 76: 32323239.

RE Sánchez , HJ Nauwynck Jr, F McNeilly , GM Allan and MB Pensaert (2001a). Porcine circovirus 2 infection in swine foetuses inoculated at different stages of gestation. Veterinary Microbiology 83: 169176.

RE Sanchez , P Meerts Jr, HJ Nauwynck and MB Pensaert (2003). Change of porcine circovirus 2 target cells in pigs during development from fetal to early postnatal life. Veterinary Microbiology 95: 1525.

RE Sanchez , P Meerts Jr, HJ Nauwynck , JA Ellis and MB Pensaert (2004). Characteristics of porcine circovirus-2 replication in lymphoid organs of pigs inoculated in late gestation or postnatally and possible relation to clinical and pathological outcome of infection. Journal of Veterinary Diagnostic Investigation 16: 175185.

C Schulze , J Segalés , G Neumann , A Hlinak , M Calsamiglia and M Domingo (2004). Identification of postweaning multisystemic wasting syndrome in European wild boar (Sus scrofa). Veterinary Record 154: 694696.

J Segalés and M Domingo (2002). Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review. Veterinary Quarterly 24: 109124.

J Segalés , J Piella , E Marco , EM Mateu-de-Antonio , E Espuna and M Domingo (1998). Porcine dermatitis and nephropathy syndrome in Spain. Veterinary Record 142: 483486.

J Segalés , F Alonso , C Rosell , J Pastor , F Chianini , E Campos , L López-Fuertes , J Quintana , G Rodríguez-Arrioja , M Calsamiglia , J Pujols , J Domínguez and M Domingo (2001). Changes in peripheral blood leukocyte populations in pigs with natural postweaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology 81: 3744.

J Segalés , M Calsamiglia , C Rosell , M Soler , J Maldonado , M Martín and M Domingo (2002). Porcine reproductive and respiratory syndrome virus (PRRSV) infection status in pigs naturally affected with post-weaning multisystemic wasting syndrome (PMWS) in Spain. Veterinary Microbiology 85: 2330.

J Segalés , M Domingo , F Chianini , N Majo , J Dominguez , L Darwich and E Mateu (2004a). Immunosuppression in postweaning multisystemic wasting syndrome affected pigs. Veterinary Microbiology 98: 151158.

J Segalés , C Rosell and M Domingo (2004b). Pathological findings associated with naturally acquired porcine circovirus type 2 associated disease. Veterinary Microbiology 98: 137149.

T Shibahara , K Sato , Y Ishikawa and K Kadota (2000). Porcine circovirus induces B lymphocyte depletion in pigs with wasting disease syndrome. Journal of Veterinary Medical Science 62: 11251131.

I Shibata , Y Okuda , S Yazawa , M Ono , T Sasaki , M Itagaki , N Nakajima , Y Okabe and I Hidejima (2003). PCR detection of porcine circovirus type 2 DNA in whole blood, serum, oropharyngeal swab, nasal swab, and feces from experimentally infected pigs and field cases. Journal of Veterinary Medical Science 65: 405408.

M Sibila , M Calsamiglia , J Segalés , P Blanchard , L Badiella , M Le Dimna , A Jestin and M Domingo (2004). Use of a polymerase chain reaction assay and an ELISA to monitor porcine circovirus type 2 infection in pigs from farms with and without postweaning multisystemic wasting syndrome. American Journal of Veterinary Research 65: 8892.

W Sipos , JC Duvigneau , M Willheim , F Schilcher , RT Hartl , G Hofbauer , B Exel , P Pietschmann and F Schmoll (2004). Systemic cytokine profile in feeder pigs suffering from natural postweaning multisystemic wasting syndrome (PMWS) as determined by semiquantitative RT-PCR and flow cytometric intracellular cytokine detection. Veterinary Immunology and Immunopathology 99: 6371.

W Sipos , JC Duvigneau , P Pietschmann , F Schilcher , G Hofbauer , RT Hartl and F Schmoll (2005). Porcine dermatitis and nephropathy syndrome (PDNS) is associated with a systemic cytokine expression profile indicative of proinflammation and a Th1 bias. Veterinary Immunology and Immunopathology 107: 303313.

T Sirinarumitr , I Morozov , P Nawagitgul , SD Sorden , PA Harms and PS Paul (2000). Utilization of a rate enhancement hybridization buffer system for rapid in situ hybridization for the detection of porcine circovirus in cell culture and in tissues of pigs with postweaning multisystemic wasting syndrome. Journal of Veterinary Diagnostic Investigation 12: 562565.

WJ Smith , JR Thomson and S Done (1993). Dermatitis/nephropathy syndrome of pigs. Veterinary Record 132: 47.

GW Stevenson , M Kiupel , SK Mittal , J Choi , KS Latimer and L Kanitz (2001). Tissue distribution and genetic typing of porcine circoviruses in pigs with naturally occurring congenital tremors. Journal of Veterinary Diagnostic Investigation 13: 5762.

S Thibault , R Drolet , MC Germain , S D'Allaire , R Larochelle and R Magar (1998). Cutaneous and systemic necrotizing vasculitis in swine. Veterinary Pathology 35: 108116.

I Tischer , H Gelderblom , W Vettermann and MA Koch (1982). A very small porcine virus with circular single-stranded DNA. Nature 295: 6466.

I Tischer , W Mields , D Wolff , M Vagt and W Griem (1986). Studies on epidemiology and pathogenicity of porcine circovirus. Archives of Virology 91: 271276.

I Tischer , D Peters , R Rasch and S Pociuli (1987). Replication of porcine circovirus: induction by glucosamine and cell cycle dependence. Archives of Virology 96: 3957.

I Tischer , L Bode , J Apodaca , H Timm , D Peters , R Rasch , S Pociuli and E Gerike (1995). Presence of antibodies reacting with porcine circovirus in sera of humans, mice, and cattle. Archives of Virology 140: 14271439.

J Vicente , J Segalés , U Hofle , M Balasch , J Plana-Duran , M Domingo and C Gortazar (2004). Epidemiological study on porcine circovirus type 2 (PCV2) infection in the European wild boar (Sus scrofa). Veterinary Research 35: 243253.

H Vigre , P Boebko , SE Jorsal , V Bille-Hansen , AG Hassing , C Enoe and A Botner (2005). Spatial and temporal patterns of pig herds diagnosed with postweaning multisystemic wasting syndrome (PMWS) in the first two years of its occurrence in Denmark. Veterinary Microbiology 110: 1726.

IE Vincent , CP Carrasco , B Herrmann , BM Meehan , GM Allan , A Summerfield and KC McCullough (2003). Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus. Journal of Virology 77: 1328813300.

IE Vincent , CP Carrasco , L Guzylack-Piriou , B Herrmann , F McNeilly , GM Allan , A Summerfield and KC McCullough (2005). Subset-dependent modulation of dendritic cell activity by circovirus type 2. Immunology 115: 388398.

IW Walker , CA Konoby , VA Jewhurst , I McNair , F McNeilly , BM Meehan , TS Cottrell , JA Ellis and GM Allan (2000). Development and application of a competitive enzyme-linked immunorbent assay for the detection of serum antibodies to porcine circovirus. Journal of Veterinary Diagnostic Investigation 12: 400405.

P Wallgren , F Hasslung , G Bergstrom , A Linder , K Belak , C Hard af Segerstad , M Stampe , B Molander , T Bjornberg Kallay , E Norregard , CJ Ehlorsson , M Tornquist , C Fossum , GM Allan and JA Robertsson (2004). Postweaning multisystemic wasting syndrome (PMWS). The first year with the disease in Sweden. Veterinary Quarterly 26: 170187.

GJ Wellenberg , N Stockhofe-Zurwieden , MF de Jong , WJ Boersma and AR Elbers (2004). Excessive porcine circovirus type 2 antibody titers may trigger the development of porcine dermatitis and nephropathy syndrome: a case-control study. Veterinary Microbiology 99: 203214.

KH West , JM Bystrom , C Wojnarowicz , N Shantz , M Jacobson , GM Allan , DM Haines , EG Clark , S Krakowka , F McNeilly , C Konoby , K Martin and JA Ellis (1999). Myocarditis and abortion associated with intrauterine infection of sows with porcine circovirus 2. Journal of Veterinary Diagnostic Investigation 11: 530532.

KJ Yoon , RJ Jepsen , RM Pogranichniy , S Sorden , R Stammer and LE Evans (2004). A novel approach to intrauterine viral inoculation of swine using PCV type 2 as a model. Theriogenology 61: 10251037.

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Animal Health Research Reviews
  • ISSN: 1466-2523
  • EISSN: 1475-2654
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