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A systematic review and meta-analysis of the antibiotic treatment for infectious bovine keratoconjunctivitis: an update

  • J. N. Cullen (a1), C. Yuan (a2), S. Totton, R. Dzikamunhenga (a1), J. F. Coetzee (a1), N. da Silva (a2), C. Wang (a1) (a2) and A. M. O'Connor (a1)...
Abstract

Infectious bovine keratoconjunctivitis (IBK) is a common and important disease of calves. Without effective vaccines, antibiotic therapy is often implemented to minimize the impact of IBK. This review updates a previously published systematic review regarding comparative efficacy for antibiotic treatments of IBK. Available years of Centre for Biosciences and Agriculture International and MEDLINE databases were searched, including non-English results. Also searched were the American Association of Bovine Practitioners and World Buiatrics Congress conference proceedings from 1996 to 2016, reviews since 2013, reference lists from relevant trials, and U.S. Food and Drug Administration New Animal Drug Application summaries. Eligible studies assessed antibiotic treatment of naturally-occurring IBK in calves randomly allocated to group at the individual level. Outcomes of interest were clinical score, healing time, unhealed ulcer risk, and ulcer surface area. A mixed-effects model comparing active drug with placebo was employed for all outcomes. Heterogeneity was assessed visually and using Cochran's Q-test. Thirteen trials assessing nine treatments were included. Compared with placebo, most antibiotic treatments were effective. There was evidence that the treatment effect differed by day of outcome measurement. Visually, the largest differences were observed 7–14 days post-treatment. These results indicate improved IBK healing with many antibiotics and suggest the need for randomized trials comparing different antibiotic treatments.

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Corresponding author
*Corresponding author. E-mail: oconnor@iastate.edu
References
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Abdala, AA, Canavesio, VR, Zimmermann, G, Abramovich, G and Calvinho, LF (2002). Two treatments for bovine infections keratoconjunctivitis Evaluacion de dos regimenes de tratamiento antibiotico topico, para Queratoconjuntivitis Infecciosa Bovina. Revista de Medicina Veterinaria (Buenos Aires) 83: 100102.
Alexander, D (2010). Infectious bovine keratoconjunctivitis: a review of cases in clinical practice. Veterinary Clinics of North America: Food Animal Practice 26: 487503.
Allen, LJ, George, LW and Willits, NH (1995). Effect of penicillin or penicillin and dexamethasone in cattle with infectious bovine keratoconjunctivitis. Journal of the American Veterinary Medical Association 206: 12001203.
Angelos, JA, Dueger, EL, George, LW, Carrier, TK, Mihalyi, JE, Cosgrove, SB and Johnson, JC (2000). Efficacy of orfenicol for treatment of naturally occurring infectious bovine keratoconjunctivitis. Journal of the American Veterinary Medical Association 216: 6264.
Angelos, JA, Spinks, PQ, Ball, LM and George, LW (2007). Moraxella bovoculi sp. nov., isolated from calves with infectious bovine keratoconjunctivitis. International Journal of Systematic and Evolutionary Microbiology 57 (Pt 4): 789795.
Brown, MH, Brightman, AH, Fenwick, BW and Rider, MA (1998). Infectious bovine keratoconjunctivitis: a review. Journal of Veterinary Internal Medicine 12: 259266.
Chadli, M (1992). Clinical evaluation of infectious bovine keratoconjunctivitis after treatment with long acting oxytetracycline La keratoconjonctivite infectieuse bovine: evaluation clinique apres traitement a l'oxytetracycline longue action. Maghreb Veterinaire 7: 3436.
Cosgrove, SB, Simmons, RD, Johnson, JC and Varma, KJ (1998). In vivo and in vitro efficacy of Nuor (orfenicol) in the treatment of infectious bovine keratoconjunctivitis. Schering-plough Animal Health Nuor: new therapeutic applications. In: Proceedings of a Symposium Held in Conjunction with the XX World Buiatrics Congress, p. 514.
Cullen, JN, Engelken, TJ, Cooper, VS and OConnor, AM (in press). A randomized, controlled, blinded trial assessing the association between infectious bovine keratoconjunctivitis incidence and a commercial Moraxella bovis vaccine in beef calves. Journal of the American Veterinary Medical Association.
Dueger, EL, George, LW, Angelos, JA, Tankersley, NS, Luiz, KM, Meyer, JA, Portis, ES and Lucas, MJ (2004). Efficacy of a long-acting formulation of ceftiofur crystalline-free acid for the treatment of naturally occurring infectious bovine keratoconjunctivitis. American Journal of Veterinary Research 65: 11851188.
Eastman, TG, George, LW, Hird, DW and Thurmond, MC (1998). Combined parenteral and oral administration of oxytetracycline for control of infectious bovine keratoconjunctivitis. Journal of the American Veterinary Medical Association 212: 560563.
Edmondson, AJ, George, LW and Farver, TB (1989). Survival analysis for evaluation of corneal ulcer healing times in calves with naturally acquired infectious bovine keratoconjunctivitis. American Journal of Veterinary Research 50: 838844.
Emarcora, M, Morassi, R, Soriolo, A, Piva, R, Bregoli, M and Schiavon, E (2010). Efficacy of tulathromycin in a outbreak of infectious bovine keratoconjunctivitis. Large Animal Review 16: 163165.
Freedom of Information Summary (2007). NADA 141-244 – DRAXXIN Injectable Solution. [Available online at http://www.fda.gov/downloads/animalveterinary/products/approvedanimaldrugproducts/foiadrugsummaries/ucm051495.pdf].
Funk, L, O'Connor, AM, Maroney, M, Engelken, T, Cooper, VL, Kinyon, J and Plummer, P (2009). A randomized and blinded field trial to assess the efficacy of an autogenous vaccine to prevent naturally occurring infectious bovine keratoconjunctivis (IBK) in beef calves. Vaccine 27: 45854590.
Funk, LD, Reecy, JM, Wang, C, Tait, RG Jr., O'Connor, AM (2014). Associations between infectious bovine keratoconjunctivitis at weaning and ultrasongraphically measured body composition traits in yearling cattle. Journal of the American Veterinary Medical Association 244: 100106.
George, L, Mihalyi, J, Edmondson, A, Daigneault, J, Kagonyera, G, Willits, N and Lucas, M (1988). Topically applied furazolidone or parenterally administered oxytetracycline for the treatment of infectious bovine keratoconjunctivitis. Journal of the American Veterinary Medical Association 192: 14151422.
George, LW, Wilson, WD, Baggot, JD and Mihalyi, JE (1984). Antibiotic treatment of Moraxella bovis infection in cattle. Journal of the American Veterinary Medical Association 185: 12061209.
George, LW, Keefe, T and Daigneault, J (1989). Effectiveness of two benzathine cloxacillin formulations for treatment of naturally occuring infectious bovine keratoconjunctivitis. American Journal of Veterinary Research 50: 11701174.
Gokce, HI, Citil, M, Genc, O, Erdogan, HM, Gunes, V and Kankavi, O (2002). A comparison of the efficacy of orfenicol and oxytetracycline in the treatment of naturally occurring infectious bovine keratoconjunctivitis. Irish Veterinary Journal 55: 573576.
Gotelli, NJ, Hart, EM and Ellison, AM (2015). EcoSimR: Null model analysis for ecological data – version 0.1.0. [Available online at http://github.com/gotellilab/EcoSimR].
Gould, S, Dewell, R, Tofflemire, K, Whitley, RD, Millman, ST, Opriessnig, T, Rosenbusch, R, Trujillo, J and O'Connor, AM (2013). Randomized blinded challenge study to assess association between Moraxella bovoculi and Infectious Bovine Keratoconjunctivitis in dairy calves. Veterinary Microbiology 164: 108115.
Higgins, J, Green, S and Cochrane Collaboration (2008). Selecting studies and collecting data. In: Julian, PT and Green, S (eds) Cochrane Handbook for Systematic Reviews of Interventions. Vol. 5. Chichester, England; Hoboken, NJ: Wiley-Blackwell.
Higgins, JP and Whitehead, A (1996). Borrowing strength from external trials in a meta-analysis. Statistics in Medicine 15: 27332749.
Hoaglin, DC (2016). Misunderstandings about Q and ‘Cochran's Q test’ in meta analysis. Statistics in Medicine 35: 485–95.
Jansen, JP, Crawford, B, Bergman, G and Stam, W (2008). Bayesian meta-analysis of multiple treatment comparisons: an introduction to mixed treatment comparisons. Value Health 11: 956964.
Jørgensen, E and Pedersen, AR (1998). How to obtain those nasty standard errors from transformed data-and why they should not be used. [Available online at http://gbi.agrsci.dk/~ejo/publications/dinapig/intrep7.pdf].
Lane, VM, George, LW and Cleaver, DM (2006). Efficacy of tulathromycin for treatment of cattle with acute ocular Moraxella bovis infections. Journal of the American Veterinary Medical Association 229: 557561.
Lu, G and Ades, AE (2004). Combination of direct and indirect evidence in mixed treatment comparisons. Statistics in Medicine 23: 31053124.
Moher, D, Liberati, A, Tetzlaff, J, Altman, DG and Prisma Group (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine 6: 16.
O'Connor, AM, Wellman, NG, Evans, RB and Roth, DR (2006). A review of randomized clinical trials reporting antibiotic treatment of infectious bovine keratoconjunctivitis in cattle. Animal Health Research Reviews 7: 119127.
O'Connor, AM, Sargeant, JM, Gardner, IA, Dickson, JS, Torrence, ME, Dewey, CE, Dohoo, IR, Evans, RB, Gray, JT, Greiner, M, Keefe, G, Lefebvre, SL, Morley, PS, Ramirez, A, Sischo, W, Smith, DR, Snedeker, K, Sofos, J, Ward, MP and Wills, R (2010). The REFLECT statement: methods and processes of creating reporting guidelines for randomized controlled trials for livestock and food safety. Preventive Veterinary Medicine 93: 11–8.
O'Connor, AM, Brace, S, Gould, S, Dewell, R and Engelken, T (2011). A randomized clinical trial evaluating a farm-of-origin autogenous Moraxella bovis vaccine to control infectious bovine keratoconjunctivis (pinkeye) in beef cattle. Journal of Veterinary Internal Medicine 25: 14471453.
Pfizer Animal Health (2008). Efficacy of DRAXXIN (tulathromycin) Injectable solution for treatment of naturally occurring infectious bovine keratoconjunctivitis associated with Moraxella bovis in beef and airy calves. [Available online at https://www.zoetisus.com/\_locale-assets/myresources/drx08001-pinkeye-tb.pdf].
Quesada, MAZ, Jeny, Aguilar A and Lopez, HS (2010). Clinical efficacy of parenteral vs ophthalmic orfenicol for the treatment of infectious bovine keratoconjunctivitis. Veterinaria Mexico 41: 219225.
R Core Team (2015). R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing.
Roeder, BL, Skogerboe, TL, Clark, FD and Kelly, EJ (1995). Effect of early treatment with parenteral long-acting oxytetracycline on performance of beef calves with acute eye lesions. Agri-Practice 16: 611.
Salanti, G, Kavvoura, FK and Ioannidis, JP (2008). Exploring the geometry of treatment networks. Annals of Internal Medicine 148: 544553.
Senturk, S, Cetin, C, Temizel, M and Ozel, E (2007). Evaluation of the clinical efficacy of subconjunctival injection of clindamycin in the treatment of naturally occurring infectious bovine keratoconjunctivitis. Veterinary Ophthalmology 10: 186189.
Starke, A, Eule, C, Meyer, H, Im Winkel, C, Verspohl, J and Rehage, J (2007). Efficacy of intrapalpebral and intramuscular application of oxytetracycline in a natural outbreak of infectious bovine kertoconjunctivitis (IBK) in calves. DTW. Deutsche tierarztliche Wochenschrift 114: 219224.
Sterne, JAC, Sutton, AJ, Ioannidis, J, Terrin, N, Jones, DR, Lau, J, Carpenter, J, Rücker, G, Harbord, RM, Schmid, CH, Tetzlaff, J, Deeks, JJ, Peters, J, Macaskill, P, Schwarzer, G, Duval, S, Altman, DG, Moher, D and Higgins, JP (2011). Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 343: 18.
Tate, MW and Brown, SM (1970). Note on the Cochran Q test. Journal of the American Statistical Association 65: 155160.
Thrift, FA and Overfield, JR (1974). Impact of pinkeye (infectious bovine kerato conjunctivitis) on weaning and postweaning performance of Hereford calves. Journal of Animal Science 38: 11791184.
Viechtbauer, W (2010). Conducting meta-analyses in R with the metafor package. Journal of Statistical Software 36: 148.
Zielinski, GC, Piscitelli, HG, Perez-Monti, H, Stobbs, LA and Zimmermann, AG (2002). Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye). Veterinary Therapeutics 3: 196205.
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