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Update on bacterial pathogenesis in BRD

  • Anthony W. Confer (a1)


Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Mycoplasma bovis and Arcanobacterium pyogenes are all frequently implicated in bovine respiratory disease (BRD). M. haemolytica is considered the most important of the group. These bacteria are commensals in the nasopharynx and establish infection in the lungs of cattle that are subjected to a variety of stresses. Factors that permit adherence to and proliferation in the lungs and factors that cause tissue destruction and inflammation have been identified as having major roles in pathogenesis. These virulence factors include protein adhesins, capsular polysaccharide, outer membrane proteins, iron-binding proteins, lipopolysacharide or lipooligosaccharide, enzymes and toxins. These bacterial products function to evade the immune system, damage the immune system and induce a severe inflammatory response.


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Allen, JW, Viel, L, Bateman, KG, Nagy, E, Røsendal, S and Shewen, PE (1992). Serological titers to bovine herpesvirus 1, bovine viral diarrhea virus, parainfluenza 3 virus, bovine respiratory syncytial virus and Pasteurella haemolytica in feedlot calves with respiratory disease: associations with bacteriological and pulmonary cytological variables. Canadian Journal of Veterinary Research 156: 281288.
Blackall, PJ, Bojesen, AM, Christensen, H and Bisgaard, M (2007). Reclassification of [Pasteurella] trehalosi as Bibersteinia trehalosi gen. nov., comb. nov. International Journal of Systematic and Evolutionary Microbiology 57: 666674.
Booker, CW, Abutarbush, SM, Morley, PS, Jim, GK, Pittman, TJ, Schunicht, OC, Perrett, T, Wildman, BK, Fenton, RK, Guichon, PT and Janzen, ED (2008). Microbiological and histopathological findings in cases of fatal bovine respiratory disease of feedlot cattle in Western Canada. Canadian Veterinary Journal 49: 473481.
Caswell, JL and Archambault, M (2007). Mycoplasma bovis pneumonia in cattle. Animal Health Research Reviews 8: 161186.
Caswell, JL and Williams, KJ (2007). Respiratory system. In: Maxie, MG (ed) Jubb, Kennedy and Palmer's Pathology of Domestic Animals, Vol. 2. Edinburgh, UK: Elsevier Ltd, pp. 601615.
Catry, B, Croubels, S, Schwarz, S, Deprez, P, Cox, B, Kehrenberg, C, Opsomer, G, Decostere, A and Haesebrouck, F (2008). Influence of systemic fluoroquinolone administration on the presence of Pasteurella multocida in the upper respiratory tract of clinically healthy calves. Acta Veterinaria Scandinavica 50: 3639.
Confer, AW, Clinkenbeard, KD and Murphy, GL (1995). Pathogenesis and virulence of Pasteurella haemolytica in cattle: an analysis of current knowledge and future approaches. In: Donachie, W, Lainson, FA and Hodgson, JC (eds) Haemophilus, Actinobacillus and Pasteurella. London: Plenum, pp. 5162.
Corbeil, LB (2007). Histophilus somni host–parasite relationships. Animal Health Research Reviews 8: 151160.
Czuprynski, CJ and Welch, RA (1995). Biological effects of RTX toxins: the possible role of lipopolysaccharide. Trends in Microbiology 3: 480483.
Czuprynski, CJ, Leite, F, Sylte, M, Kuckleburg, C, Schultz, R, Inzana, T, Behling-Kelly, E and Corbeil, L (2004). Complexities of the pathogenesis of Mannheimia haemolytica and Haemophilus somnus infections: challenges and potential opportunities for prevention? Animal Health Research Reviews 5: 277282.
Dabo, SM, Taylor, JD and Confer, AW (2007). Pasteurella multocida and bovine respiratory disease. Animal Health Research Reviews 8: 129150.
Dungworth, DC (1985). The respiratory system. In: Jubb, KVF, Kennedy, PC and Palmer, N (eds) Pathology of Domestic Animals. Orlando, FL: Academic Press, pp. 448489.
Gagea, MI, Bateman, KG, Shanahan, RA, van Dreumel, T, McEwen, BJ, Carman, S, Archambault, M and Caswell, JL (2006a). Naturally occurring Mycoplasma bovis-associated pneumonia and polyarthritis in feedlot beef calves. Journal of Veterinary Diagnostic Investigation 18: 2940.
Gagea, MI, Bateman, KG, van Dreumel, T, McEwen, BJ, Carman, S, Archambault, M, Shanahan, RA and Caswell, JL (2006b). Diseases and pathogens associated with mortality in Ontario beef feedlots. Journal of Veterinary Diagnostic Investigation 18: 1828.
Goodwin-Ray, KA, Stevenson, MA and Heuer, C (2008). Effect of vaccinating lambs against pneumonic pasteurellosis under New Zealand field conditions on their weight gain and pneumonic lung lesions at slaughter. Veterinary Record 162: 911.
Harper, M, Boyce, JD and Adler, B (2006). Pasteurella multocida pathogenesis: 125 years after Pasteur. FEMS Microbiology Letters 265: 110.
Hoshinoo, K, Sasaki, K, Tanaka, A, Corbeil, LB and Tagawa, Y (2009). Virulence attributes of Histophilus somni with a deletion mutation in the ibpA gene. Microbial Pathogenesis 46: 273282.
Jost, BH and Billington, SJ (2005). Arcanobacterium pyogenes: molecular pathogenesis of an animal opportunist. Antonie Van Leeuwenhoek 88: 87102.
Khodakaram-Tafti, A and López, A (2004). Immunohistopathological findings in the lungs of calves naturally infected with Mycoplasma bovis. Journal of Veterinary Medicine A: Physiology, Pathology, and Clinical Medicine 51: 1014.
Lopez, A (2007). Respiratory system. In: McGavin, MD and Zachary, JF (eds) Pathologic Basis of Veterinary Disease, 4th edn.St. Louis, MO: Mosby, pp. 463558.
Pietrocola, G, Valtulina, V, Rindi, S, Jost, BH and Speziale, P (2007). Functional and structural properties of CbpA, a collagen-binding protein from Arcanobacterium pyogenes. Microbiology 153: 33803389.
Rice, JA, Carrasco-Medina, L, Hodgins, DC and Shewen, PE (2007). Mannheimia haemolytica and bovine respiratory disease. Animal Health Research Reviews 8: 117128.
Rudnick, ST, Jost, BH and Billington, SJ (2008). Transcriptional regulation of pyolysin production in the animal pathogen, Arcanobacterium pyogenes. Veterinary Microbiology 132: 96104.
Sandal, I, Shao, JQ, Annadata, S, Apicella, MA, Boye, M, Jensen, TK, Saunders, GK and Inzana, TJ (2009). Histophilus somni biofilm formation in cardiopulmonary tissue of the bovine host following respiratory challenge. Microbes and Infection 11: 254263.
Thomson, RG (1984). Pathogenesis of pneumonia in feedlot cattle. In: Loan, RW (ed.) Bovine Respiratory Disease: A Symposium. College Station, TX: Texas A&M University Press, pp. 326346.
Welsh, RD, Dye, LB, Payton, ME and Confer, AW (2004). Frequency of isolation and antimicrobial susceptibilities of bacterial pathogens from bovine pneumonia: 1994–2002. Journal of Veterinary Diagnostic Investigation 16: 426431.



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