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Vaccine development for protecting swine against influenza virus

  • Qi Chen (a1), Darin Madson (a2), Cathy L. Miller (a1) and D.L. Hank Harris (a2) (a3) (a4)
Abstract

Influenza virus infects a wide variety of species including humans, pigs, horses, sea mammals and birds. Weight loss caused by influenza infection and/or co-infection with other infectious agents results in significant financial loss in swine herds. The emergence of pandemic H1N1 (A/CA/04/2009/H1N1) and H3N2 variant (H3N2v) viruses, which cause disease in both humans and livestock constitutes a concerning public health threat. Influenza virus contains eight single-stranded, negative-sense RNA genome segments. This genetic structure allows the virus to evolve rapidly by antigenic drift and shift. Antigen-specific antibodies induced by current vaccines provide limited cross protection to heterologous challenge. In pigs, this presents a major obstacle for vaccine development. Different strategies are under development to produce vaccines that provide better cross-protection for swine. Moreover, overriding interfering maternal antibodies is another goal for influenza vaccines in order to permit effective immunization of piglets at an early age. Herein, we present a review of influenza virus infection in swine, including a discussion of current vaccine approaches and techniques used for novel vaccine development.

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*Corresponding author. E-mail: hharris@harrisvaccines.com
References
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Akarsu, H, Iwatsuki-Horimoto, K, Noda, T, Kawakami, E, Katsura, H, Baudin, F, Horimoto, T and Kawaoka, Y (2011). Structure-based design of NS2 mutants for attenuated influenza A virus vaccines. Virus Research 155: 240248.
Alexander, DJ and Brown, IH (2000). Recent zoonoses caused by influenza A viruses. Revue Scientifique et Technique 19: 197225.
Babiuk, S, Masic, A, Graham, J, Neufeld, J, van der Loop, M, Copps, J, Berhane, Y, Pasick, J, Potter, A, Babiuk, LA, Weingartl, H and Zhou, Y (2011). An elastase-dependent attenuated heterologous swine influenza virus protects against pandemic H1N1 2009 influenza challenge in swine. Vaccine 29: 31183123.
Bachrach, HL (1982). Recombinant DNA technology for the preparation of subunit vaccines. Journal of the American Veterinary Medical Association 181: 992999.
Backstrom, WE, Abdurahman, S, Tranell, A, Lindstrom, S, Tingsborg, S and Schwartz, S (2011). Inefficient splicing of segment 7 and 8 mRNAs is an inherent property of influenza virus A/Brevig Mission/1918/1 (H1N1) that causes elevated expression of NS1 protein. Virology 422: 4658.
Baltimore, D, Huang, AS and Stampfer, M (1970). Ribonucleic acid synthesis of vesicular stomatitis virus, II. An RNA polymerase in the virion. Proceedings of the National Academy of Sciences of the United States of America 66: 572576.
Belshe, RB (2004). Current status of live attenuated influenza virus vaccine in the US. Virus Research 103: 177185.
Bosworth, B, Erdman, MM, Stine, DL, Harris, I, Irwin, C, Jens, M, Loynachan, A, Kamrud, K and Harris, DL (2010). Replicon particle vaccine protects swine against influenza. Comparative Immunology, Microbiology and Infectious Diseases 33: e99e103.
Bouvier, NM and Palese, P (2008). The biology of influenza viruses. Vaccine 26 (Suppl 4): D4953.
Braucher, DR, Henningson, JN, Loving, CL, Vincent, AL, Kim, E, Steitz, J, Gambotto, AA and Kehrli, ME Jr, (2012). Intranasal vaccination with replication-defective adenovirus type 5 encoding influenza virus hemagglutinin elicits protective immunity to homologous challenge and partial protection to heterologous challenge in pigs. Clinical and Vaccine Immunology 19: 17221729.
Bright, RA, Carter, DM, Daniluk, S, Toapanta, FR, Ahmad, A, Gavrilov, V, Massare, M, Pushko, P, Mytle, N, Rowe, T, Smith, G and Ross, TM (2007). Influenza virus-like particles elicit broader immune responses than whole virion inactivated influenza virus or recombinant hemagglutinin. Vaccine 25: 38713878.
Brown, IH (2000). The epidemiology and evolution of influenza viruses in pigs. Veterinary Microbiology 74: 2946.
Brown, IH, Harris, PA, McCauley, JW and Alexander, DJ (1998). Multiple genetic reassortment of avian and human influenza A viruses in European pigs, resulting in the emergence of an H1N2 virus of novel genotype. Journal of General Virology 79: 29472955.
CDC (2012). Seasonal influenza (flu): H3N2v and you. Centers for Disease Control and Prevention, Atlanta, GA. Available from: http://www.cdc.gov/flu/swineflu/h3n2v-basics.html (Accessed 19 September 2012).
Chan, W, Zhou, H, Kemble, G and Jin, H (2008). The cold adapted and temperature sensitive influenza A/Ann Arbor/6/60 virus, the master donor virus for live attenuated influenza vaccines, has multiple defects in replication at the restrictive temperature. Virology 380: 304311.
Charley, B, Riffault, S and Van Reeth, K (2006). Porcine innate and adaptative immune responses to influenza and coronavirus infections. Impact of Emerging Zoonotic Diseases on Animal Health 1081: 130136.
Choi, YK, Goyal, SM, Farnham, MW and Joo, HS (2002). Phylogenetic analysis of H1N2 isolates of influenza A virus from pigs in the United States. Virus Research 87: 173179.
Conzelmann, KK (1998). Nonsegmented negative-strand RNA viruses: genetics and manipulation of viral genomes. Annual Review of Genetics 32: 123162.
Cox, MM and Hollister, JR (2009). FluBlok, a next generation influenza vaccine manufactured in insect cells. Biologicals: Journal of the International Association of Biological Standardization 37: 182189.
Cox, RJ, Brokstad, KA and Ogra, P (2004). Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines. Scandinavian Journal of Immunology 59: 115.
D'Aoust, MA, Lavoie, PO, Couture, MM, Trepanier, S, Guay, JM, Dargis, M, Mongrand, S, Landry, N, Ward, BJ and Vezina, LP (2008). Influenza virus-like particles produced by transient expression in Nicotiana benthamiana induce a protective immune response against a lethal viral challenge in mice. Plant Biotechnology Journal 6: 930940.
Dhama, K, Mahendran, M, Gupta, PK and Rai, A (2008). DNA vaccines and their applications in veterinary practice: current perspectives. Veterinary Research Communications 32: 341356.
Dickerma, RW, Baker, GJ, Ordonez, JV and Scherer, WF (1973). Venezuelan equine encephalomyelitis viremia and antibody-responses of pigs and cattle. American Journal of Veterinary Research 34: 357361.
Domingo, E, Baranowski, E, Ruiz-Jarabo, CM, Martin-Hernandez, AM, Saiz, JC and Escarmis, C (1998). Quasispecies structure and persistence of RNA viruses. Emerging Infectious Diseases 4: 521527.
Draayer, HA (2004). Autogenous vaccines: determining product need and antigen selection, production and testing considerations. Developments in Biologicals 117: 4347.
Easterday, BC and Van Reeth, K (1999). Swine influenza. In: Straw, BE, D'Allaire, S, Mengling, WL and Taylor, DJ (eds) Diseases of Swine, 8th edn. Ames, IA: ISU Press, pp. 277290.
Ellis, J, Clark, E, Haines, D, West, K, Krakowka, S, Kennedy, S and Allan, GM (2004). Porcine circovirus-2 and concurrent infections in the field. Veterinary Microbiology 98: 159163.
Erdman, MM, Kamrud, KI, Harris, DL and Smith, J (2010). Alphavirus replicon particle vaccines developed for use in humans induce high levels of antibodies to influenza virus hemagglutinin in swine: proof of concept. Vaccine 28: 594596.
Fablet, C, Marois-Crehan, C, Simon, G, Grasland, B, Jestin, A, Kobisch, M, Madec, F and Rose, N (2012). Infectious agents associated with respiratory diseases in 125 farrow-to-finish pig herds: a cross-sectional study. Veterinary Microbiology 157: 152163.
Foley, PL (2001). Vaccine against swine influenza virus. U.S. Patent No. 6287570. Huxley, IA.
Gabriel, G, Garn, H, Wegmann, M, Renz, H, Herwig, A, Klenk, HD and Stech, J (2008). The potential of a protease activation mutant of a highly pathogenic avian influenza virus for a pandemic live vaccine. Vaccine 26: 956965.
Garten, RJ, Davis, CT, Russell, CA, Shu, B, Lindstrom, S, Balish, A, Sessions, WM, Xu, X, Skepner, E, Deyde, V, Okomo-Adhiambo, M, Gubareva, L, Barnes, J, Smith, CB, Emery, SL, Hillman, MJ, Rivailler, P, Smagala, J, Graaf, MD, Burke, DF, Fouchier, RAM, Pappas, C, Alpuche-Aranda, CM, López-Gatell, H, Olivera, H, López, I, Myers, CA, Faix, D, Blair, PJ, Yu, C, Keene, KM, Dotson, PD Jr., Boxrud, D, Sambol, AR, Abid, SH, George, KS, Bannerman, T, Moore, AL, Stringer, DJ, Blevins, P, Demmler-Harrison, GJ, Ginsberg, M, Kriner, P, Waterman, S, Smole, S, Guevara, HF, Belongia, EA, Clark, PA, Beatrice, ST, Donis, R, Katz, J, Finelli, L, Bridges, CB, Shaw, M, Jernigan, DB, Uyeki, TM, Smith, DJ, Klimov, AI and Cox, NJ. (2009). Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science 325: 197201.
Gauger, PC and Vincent, AL (2012). Swine influenza virus: epidemiology and vaccine concerns. In: Proceedings of the 19th Annual Swine Disease Conference for Swine Practitioners, November 10–11, 2011, Ames, Iowa, pp. 1321.
Gauger, PC, Vincent, AL, Loving, CL, Lager, KM, Janke, BH, Kehrli, ME and Roth, JA (2011). Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus. Vaccine 29: 27122719.
Gorres, JP, Lager, KM, Kong, WP, Royals, M, Todd, JP, Vincent, AL, Wei, CJ, Loving, CL, Zanella, EL, Janke, B, Kehrli, ME, Nabel, GJ and Rao, SS (2011). DNA vaccination elicits protective immune responses against pandemic and classic swine influenza viruses in pigs. Clinical and Vaccine Immunology 18: 19871995.
Gramer, MR, Lee, JH, Choi, YK, Goyal, SM and Joo, HS (2007). Serologic and genetic characterization of North American H3N2 swine influenza A viruses. Canadian Journal of Veterinary Research (Revue Canadienne De Recherche Veterinaire) 71: 201206.
Grienke, U, Schmidtke, M, von Grafenstein, S, Kirchmair, J, Liedl, KR and Rollinger, JM (2012). Influenza neuraminidase: a druggable target for natural products. Natural Product Reports 29: 1136.
Hale, BG, Randall, RE, Ortin, J and Jackson, D (2008). The multifunctional NS1 protein of influenza A viruses. Journal of General Virology 89: 23592376.
Harkness, JW, Schild, GC, Lamont, PH and Brand, CM (1972). Studies on relationships between human and porcine influenza 0.1. Serological evidence of infection in swine in Great Britain with an influenza A virus antigenically like human Hong Kong/68 virus. Bulletin of the World Health Organization 46: 709719.
Hause, BM, Oleson, TA, Bey, RF, Stine, DL and Simonson, RR (2010). Antigenic categorization of contemporary H3N2 swine influenza virus isolates using a high-throughput serum neutralization assay. Journal of Veterinary Diagnostic Investigation 22: 352359.
Heinen, PP, Van Nieuwstadt, AP, de Boer-Luijtze, EA and Bianchi, ATJ (2001). Analysis of the quality of protection induced by a porcine influenza A vaccine to challenge with an H3N2 virus. Veterinary Immunology and Immunopathology 82: 3956.
Hjulsager, CK, Bragstad, K, Bøtner, A, Nielsen, EO, Vigre, H, Enøe, C and Larsen, LE (2006). New swine influenza A H1N2 reassortment found in Danish swine. In: Proceedings of the 19th IPVS Congress, July 16–19, 2006, Copenhagen, Denmark, Vol. 1, p. 265.
Karasin, AI, Brown, IH, Carman, S and Olsen, CW (2000). Isolation and characterization of H4N6 avian influenza viruses from pigs with pneumonia in Canada. Journal of Virology 74: 93229327.
Kida, H, Ito, T, Yasuda, J, Shimizu, Y, Itakura, C, Shortridge, KF, Kawaoka, Y and Webster, RG (1994). Potential for transmission of avian influenza-viruses to pigs. Journal of General Virology 75: 21832188.
Kitikoon, P, Nilubol, D, Erickson, BJ, Janke, BH, Hoover, TC, Sornsen, SA and Thacker, EL (2006). The immune response and maternal antibody interference to a heterologous H1N1 swine influenza virus infection following vaccination. Veterinary Immunology and Immunopathology 112: 117128.
Kitikoon, P, Vincent, AL, Gauger, PC, Schlink, SN, Bayles, DO, Gramer, MR, Darnell, D, Webby, RJ, Lager, KM, Swenson, SL and Klimov, A (2012). Pathogenicity and transmission in pigs of the novel A(H3N2)v influenza virus isolated from humans and characterization of swine H3N2 viruses isolated in 2010–2011. Journal of Virology 86: 68046814.
Klumpp, K, Ruigrok, RW and Baudin, F (1997). Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structure. EMBO Journal 16: 12481257.
Klupp, BG, Hengartner, CJ, Mettenleiter, TC and Enquist, LW (2004). Complete, annotated sequence of the pseudorabies virus genome. Journal of Virology 78: 424440.
Kumar, SR, Deflube, L, Biswas, M, Shobana, R and Elankumaran, S (2011). Genetic characterization of swine influenza viruses (H3N2) isolated from Minnesota in 2006–2007. Virus Genes 43: 161176.
Kyriakis, CS, De Vleeschauwer, A, Barbe, F, Bublot, M and Van Reeth, K (2009). Safety, immunogenicity and efficacy of poxvirus-based vector vaccines expressing the haemagglutinin gene of a highly pathogenic H5N1 avian influenza virus in pigs. Vaccine 27: 22582264.
Landry, N, Ward, BJ, Trepanier, S, Montomoli, E, Dargis, M, Lapini, G and Vezina, LP (2010). Preclinical and clinical development of plant-made virus-like particle vaccine against avian H5N1 influenza. Plos ONE 5: e15559.
Larsen, DL and Olsen, CW (2002). Effects of DNA dose, route of vaccination, and coadministration of porcine interleukin-6 DNA on results of DNA vaccination against influenza virus infection in pigs. American Journal of Veterinary Research 63: 653659.
Larsen, DL, Karasin, A, Zuckermann, F and Olsen, CW (2000). Systemic and mucosal immune responses to H1N1 influenza virus infection in pigs. Veterinary Microbiology 74: 117131.
Larsen, DL, Karasin, A and Olsen, CW (2001). Immunization of pigs against influenza virus infection by DNA vaccine priming followed by killed-virus vaccine boosting. Vaccine 19: 28422853.
Lee, JH, Gramer, MR and Joo, H (2007). Efficacy of swine influenza virus vacines against an H3N2 virus variant. Canadian Journal of Veterinary Research 71: 207212.
Li, GX, Zhou, YJ, Yu, H, Tian, ZJ, Yan, LP, Zhang, Q, Hu, SP and Tong, GZ (2010). Prime-boost immunization with HA/C3d DNA followed by a recombinant pseudorabies virus boost enhanced protective immunity against H3N2 swine influenza virus in mice. Research in Veterinary Science 88: 345351.
Lim, YK, Takada, A, Tanizaki, T, Ozaki, H, Okazaki, K and Kida, H (2001). Mucosal vaccination against influenza: protections of pigs immunized with inactivated virus and ether-split vaccine. Japanese Journal of Veterinary Research 48: 197203.
Liu, Q, Ma, J, Liu, H, Qi, W, Anderson, J, Henry, SC, Hesse, RA, Richt, JA and Ma, W (2012). Emergence of novel reassortant H3N2 swine influenza viruses with the 2009 pandemic H1N1 genes in the United States. Archives of Virology 157: 555562.
Lorusso, A, Vincent, AL, Harland, ML, Alt, D, Bayles, DO, Swenson, SL, Gramer, MR, Russell, CA, Smith, DJ, Lager, KM and Lewis, NS (2011). Genetic and antigenic characterization of H1 influenza viruses from United States swine from 2008. Journal of General Virology 92: 919930.
Ma, W and Richt, JA (2010). Swine influenza vaccines: current status and future perspectives. Animal Health Research Reviews/Conference of Research Workers in Animal Diseases 11: 8196.
Ma, W, Vincent, AL, Lager, KM, Janke, BH, Henry, SC, Rowland, RR, Hesse, RA and Richt, JA (2010). Identification and characterization of a highly virulent triple reassortant H1N1 swine influenza virus in the United States. Virus Genes 40: 2836.
Ma, W, Belisle, SE, Mosier, D, Li, X, Stigger-Rosser, E, Liu, Q, Qiao, C, Elder, J, Webby, R, Katze, MG and Richt, JA (2011). 2009 pandemic H1N1 influenza virus causes disease and upregulation of genes related to inflammatory and immune responses, cell death, and lipid metabolism in pigs. Journal of Virology 85: 1162611637.
Macklin, MD, McCabe, D, McGregor, MW, Neumann, V, Meyer, T, Callan, R, Hinshaw, VS and Swain, WF (1998). Immunization of pigs with a particle-mediated DNA vaccine to influenza A virus protects against challenge with homologous virus. Journal of Virology 72: 14911496.
Maclachlan, NJ and Dubovi, EJ (2011). Chapter 21: Orthomyxoviridae. In: Maclachlan, NJ and Dubovi, EJ (eds) Fenner's Veterinary Virology, 4th edn. Saint Louis, MO: Academic Press, pp. 360380.
Mahy, BWJ (1997). Influenza A virus (FLUA). In Mahy, BWJ (eds) A Dictionary of Virology, 2nd edn. San Diego, CA: Academic Press, pp. 170171.
Markowska-Daniel, I, Pomorska-Mol, M and Pejsak, Z (2011). The influence of age and maternal antibodies on the postvaccinal response against swine influenza viruses in pigs. Veterinary Immunology and Immunopathology 142: 8186.
Masic, A, Babiuk, LA and Zhou, Y (2009). Reverse genetics-generated elastase-dependent swine influenza viruses are attenuated in pigs. Journal of General Virology 90: 375385.
Masic, A, Lu, X, Li, J, Mutwiri, GK, Babiuk, LA, Brown, EG and Zhou, Y (2010). Immunogenicity and protective efficacy of an elastase-dependent live attenuated swine influenza virus vaccine administered intranasally in pigs. Vaccine 28: 70987108.
Matsuda, M, Suizu, F, Hirata, N, Miyazaki, T, Obuse, C and Noguchi, M (2010). Characterization of the interaction of influenza virus NS1 with Akt. Biochemical and Biophysical Research Communications 395: 312317.
Moreno, A, Di Trani, L, Alborali, L, Vaccari, G, Barbieri, I, Falcone, E, Sozzi, E, Puzelli, S, Ferri, G and Cordioli, P (2010). First pandemic H1N1 outbreak from a pig farm in Italy. Open Virology Journal 4: 5256.
Murphy, FA, Gibbs, EPJ, Horzinek, MC and Studdert, J (1999). Chapter 30: Orthomyxoviridae. In: Murphy, FA, Gibbs, EPJ, Horzinek, MC and Studdert, J (eds) Veterinary Virology, 3rd edn. San Diego, CA: Academic Press, pp. 459468.
Myers, T (2010). Subunit vaccine. In: Myers, T (eds) Mosby's Medical Dictionary. Saint Louis, MO: Academic Press, pp. 1778.
Neirynck, S, Deroo, T, Saelens, X, Vanlandschoot, P, Jou, WM and Fiers, W (1999). A universal influenza A vaccine based on the extracellular domain of the M2 protein. Nature Medicine 5: 11571163.
Nelson, MI, Vincent, AL, Kitikoon, P, Holmes, EC and Gramer, MR (2012). Evolution of novel reassortant A/H3N2 influenza viruses in North American swine and humans, 2009–2011. Journal of Virology 86: 88728878.
Nivitchanyong, T, Yongkiettrakul, S, Kramyu, J, Pannengpetch, S and Wanasen, N (2011). Enhanced expression of secretable influenza virus neuraminidase in suspension mammalian cells by influenza virus nonstructural protein 1. Journal of Virological Methods 178: 4451.
O'Neill, RE, Talon, J and Palese, P (1998). The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins. EMBO Journal 17: 288296.
Olsen, CW (2000). DNA vaccination against influenza viruses: a review with emphasis on equine and swine influenza. Veterinary Microbiology 74: 149164.
Olsen, CW, Karasin, AI, Carman, S, Li, Y, Bastien, N, Ojkic, D, Alves, D, Charbonneau, G, Henning, BM, Low, DE, Burton, L and Broukhanski, G (2006). Triple reassortant H3N2 influenza A viruses, Canada, 2005. Emerging Infectious Diseases 12: 11321135.
Opriessnig, T, Gimenez-Lirola, LG and Halbur, PG (2011). Polymicrobial respiratory disease in pigs. Animal Health Research Reviews/Conference of Research Workers in Animal Diseases 12: 133148.
Paillot, R, Hannant, D, Kydd, JH and Daly, JM (2006). Vaccination against equine influenza: quid novi? Vaccine 24: 40474061.
Pandey, A, Singh, N, Vemula, SV, Couetil, L, Katz, JM, Donis, R, Sambhara, S and Mittal, SK (2012). Impact of preexisting adenovirus vector immunity on immunogenicity and protection conferred with an adenovirus-based H5N1 influenza vaccine. Plos ONE 7: e33428.
Pensaert, M, Labarque, G, Favoreel, H and Nauwynck, H (2004). Aujeszky's disease vaccination and differentiation of vaccinated from infected pigs. Developments in Biologicals 119: 243254.
Pertmer, TM, Eisenbraun, MD, McCabe, D, Prayaga, SK, Fuller, DH and Haynes, JR (1995). Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA. Vaccine 13: 14271430.
Pfizer Inc. (2011). FluSure XP helping guard against current flu strains. Pfizer Inc. Available online at http://www.flusurexp.com/FluSureXP/FluSureXP.html (Accessed 29 June 2012).
Pfizer Inc. (2012). 2010 (January-November) UMVDL SIV Surveillance. Pfizer Inc. Available online at http://www.flusurexp.com/AboutSIV/SIV-diagnostic-trends.html (Accessed 19 January 2012).
Platt, R, Vincent, AL, Gauger, PC, Loving, CL, Zanella, EL, Lager, KM, Kehrli, ME Jr, Kimura, K and Roth, JA (2011). Comparison of humoral and cellular immune responses to inactivated swine influenza virus vaccine in weaned pigs. Veterinary Immunology and Immunopathology 142: 252257.
Pushko, P, Parker, M, Ludwig, GV, Davis, NL, Johnston, RE and Smith, JF (1997). Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo. Virology 239: 389401.
Rapp-Gabrielson, VJ, Sornsen, S, Nitzel, G, Wicklund, E, Wood, MD, Kuhn, M and Gramer, M (2008). Updating swine influenza vaccines. In: AASV 39th Annual Meeting Proceedings, March 8–11, 2008, San Diego, CA, pp. 261264.
Rayner, JO, Dryga, SA and Kamrud, KI (2002). Alphavirus vectors and vaccination. Reviews in Medical Virology 12: 279296.
Richt, JA, Lager, KM, Janke, BH, Woods, RD, Webster, RG and Webby, RJ (2003). Pathogenic and antigenic properties of phylogenetically distinct reassortant H3N2 swine influenza viruses cocirculating in the United States. Journal of Clinical Microbiology 41: 31983205.
Richt, JA, Lekcharoensuk, P, Lager, KM, Vincent, AL, Loiacono, CM, Janke, BH, Wu, WH, Yoon, KJ, Webby, RJ, Solorzano, A and Garcia-Sastre, A (2006). Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine. Journal of Virology 80: 1100911018.
Rimmelzwaan, GF and Sutter, G (2009). Candidate influenza vaccines based on recombinant modified vaccinia virus Ankara. Expert Review of Vaccines 8: 447454.
Romagosa, A, Allerson, M, Gramer, M, Joo, HS, Deen, J, Detmer, S and Torremorell, M (2011). Vaccination of influenza a virus decreases transmission rates in pigs. Veterinary Research 42: 120.
Sanofi Pasteur (2009). Sanofi Pasteur's bulk influenza vaccine manufacturing process. Sanifo-Aventis Group. Available online at http://www.vaccineplace.com/docs/bulkvaccinemanufacturing.pdf (Accessed 19 January 2012).
Shaw, ML, Stone, KL, Colangelo, CM, Gulcicek, EE and Palese, P (2008). Cellular proteins in influenza virus particles. PLoS Pathogens 4: e1000085.
Shoji, Y, Chichester, JA, Jones, M, Manceva, SD, Damon, E, Mett, V, Musiychuk, K, Bi, H, Farrance, C, Shamloul, M, Kushnir, N, Sharma, S and Yusibov, V (2011). Plant-based rapid production of recombinant subunit hemagglutinin vaccines targeting H1N1 and H5N1 influenza. Human Vaccines 7 (Suppl): 4150.
Shope, RE (1931). Swine influenza : III. Filtration experiments and etiology. Journal of Experimental Medicine 54: 373385.
Skehel, JJ and Wiley, DC (2000). Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annual Review of Biochemistry 69: 531569.
Smerdou, C and Liljestrom, P (1999). Two-helper RNA system for production of recombinant Semliki forest virus particles. Journal of Virology 73: 10921098.
Solorzano, A, Webby, RJ, Lager, KM, Janke, BH, Garcia-Sastre, A and Richt, JA (2005). Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. Journal of Virology 79: 75357543.
Stech, J, Garn, H, Wegmann, M, Wagner, R and Klenk, HD (2005). A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin. Nature Medicine 11: 683689.
Talon, J, Salvatore, M, O'Neill, RE, Nakaya, Y, Zheng, H, Muster, T, Garcia-Sastre, A and Palese, P (2000). Influenza A and B viruses expressing altered NS1 proteins: a vaccine approach. Proceedings of the National Academy of Sciences of the United States of America 97: 43094314.
Thacker, EL, Thacker, BJ and Janke, BH (2001). Interaction between Mycoplasma hyopneumoniae and swine influenza virus. Journal of Clinical Microbiology 39: 25252530.
Thompson, JM, Nicholson, MG, Whitmore, AC, Zamora, M, West, A, Iwasaki, A, Staats, HF and Johnston, RE (2008). Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node. Journal of Immunology 181: 574585.
Tian, ZJ, Zhou, GH, Zheng, BL, Qiu, HJ, Ni, JQ, Yang, HL, Yin, XN, Hu, SP and Tong, GZ (2006). A recombinant pseudorabies virus encoding the HA gene from H3N2 subtype swine influenza virus protects mice from virulent challenge. Veterinary Immunology and Immunopathology 111: 211218.
Tong, SX, Li, Y, Rivailler, P, Conrardy, C, Castillo, DAA, Chen, LM, Recuenco, S, Ellison, JA, Davis, CT, York, IA, Turmelle, AS, Moran, D, Rogers, S, Shi, M, Tao, Y, Weil, MR, Tang, K, Rowe, LA, Sammons, S, Xu, XY, Frace, M, Lindblade, KA, Cox, NJ, Anderson, LJ, Rupprecht, CE and Donis, RO (2012). A distinct lineage of influenza A virus from bats. Proceedings of the National Academy of Sciences of the United States of America 109: 42694274.
Tremblay, D, Allard, V, Doyon, JF, Bellehumeur, C, Spearman, JG, Harel, J and Gagnon, CA (2011). Emergence of a new swine H3N2 and pandemic (H1N1) 2009 influenza A virus reassortant in two Canadian animal populations, mink and swine. Journal of Clinical Microbiology 49: 43864390.
USDA (2007). Swine 2006 Part II: Reference of Swine Health and Health Management Practices in the United States, 2006. Fort Collins, CO:USDA:APHIS:VS. Available online at http://www.aphis.usda.gov/animal_health/nahms/swine/downloads/swine2006/Swine2006_dr_PartII.pdf (Accessed 29 June 2012).
USDA (2012a). Swine Influenza Vaccine, RNA. Ames, IA: USDA:CVB. Available online at http://www.aphis.usda.gov/animal_health/vet_biologics/publications/notice_12_20.pdf (Accessed 19 October 2012).
USDA (2012b). Acceptance of product license applications for autogenous nonviable recombinant and autogenous subunit vaccines directed against rotavirus group C. Ames, IA: USDA:CVB. Available online at http://www.aphis.usda.gov/animal_health/vet_biologics/publications/drafts_memos_notices.pdf (Accessed 29 June 2012).
Vander Veen, R, Kamrud, K, Mogler, M, Loynachan, AT, McVicker, J, Berglund, P, Owens, G, Timberlake, S, Lewis, W, Smith, J and Harris, DL (2009). Rapid development of an efficacious swine vaccine for novel H1N1. PLoS Currents 1: RRN1123.
Vander Veen, RL (2011). Development of efficacious replicon particle vaccines for swine influenza virus. Graduate Theses and Dissertations Paper 10373. Available online at http://lib.dr.iastate.edu/etd/10373 (Accessed 29 June 2012).
Vander Veen, RL, Harris, DL and Kamrud, KI (2012a). Alphavirus replicon vaccines. Animal Health Research Reviews 13: 19.
Vander Veen, RL, Loynachan, AT, Mogler, MA, Russell, BJ, Harris, DL and Kamrud, KI (2012b). Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine. Vaccine 30: 19441950.
Van Reeth, K (2000). Cytokines in the pathogenesis of influenza. Veterinary Microbiology 74: 109116.
Verheust, C, Goossens, M, Pauwels, K and Breyer, D (2012). Biosafety aspects of modified vaccinia virus Ankara (MVA)-based vectors used for gene therapy or vaccination. Vaccine 30: 26232632.
Vincent, AL, Lager, KM, Ma, W, Lekcharoensuk, P, Gramer, MR, Loiacono, C and Richt, JA (2006). Evaluation of hemagglutinin subtype 1 swine influenza viruses from the United States. Veterinary Microbiology 118: 212222.
Vincent, AL, Ma, W, Lager, KM, Janke, BH, Webby, RJ, Garcia-Sastre, A and Richt, EA (2007). Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine. Vaccine 25: 79998009.
Vincent, AL, Ma, W, Lager, KM, Janke, BH and Richt, JA (2008a). Swine influenza viruses: a North American perspective. Advances in Virus Research 72: 127154.
Vincent, AL, Lager, KM, Janke, BH, Gramer, MR and Richt, JA (2008b). Failure of protection and enhanced pneumonia with a US H1N2 swine influenza virus in pigs vaccinated with an inactivated classical swine H1N1 vaccine. Veterinary Microbiology 126: 310323.
Vincent, AL, Ma, W, Lager, KM, Gramer, MR, Richt, JA and Janke, BH (2009). Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States. Virus Genes 39: 176185.
Vincent, AL, Ciacci-Zanella, JR, Lorusso, A, Gauger, PC, Zanella, EL, Kehrli, ME Jr, Janke, BH and Lager, KM (2010a). Efficacy of inactivated swine influenza virus vaccines against the 2009 A/H1N1 influenza virus in pigs. Vaccine 28: 27822787.
Vincent, AL, Lager, KM, Faaberg, KS, Harland, M, Zanella, EL, Ciacci-Zanella, JR, Kehrli, ME Jr, Janke, BH and Klimov, A (2010b). Experimental inoculation of pigs with pandemic H1N1 2009 virus and HI cross-reactivity with contemporary swine influenza virus antisera. Influenza and Other Respiratory Viruses 4: 5360.
Wang, C, Takeuchi, K, Pinto, LH and Lamb, RA (1993). Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. Journal of Virology 67: 55855594.
Webby, RJ, Swenson, SL, Krauss, SL, Gerrish, PJ, Goyal, SM and Webster, RG (2000). Evolution of swine H3N2 influenza viruses in the United States. Journal of Virology 74: 82438251.
Webby, RJ, Rossow, K, Erickson, G, Sims, Y and Webster, R (2004). Multiple lineages of antigenically and genetically diverse influenza A virus co-circulate in the United States swine population. Virus Research 103: 6773.
Webster, RG (1999). 1918 Spanish influenza: the secrets remain elusive. Proceedings of the National Academy of Sciences of the United States of America 96: 11641166.
Wesley, RD and Lager, KM (2006). Overcoming maternal antibody interference by vaccination with human adenovirus 5 recombinant viruses expressing the hemagglutinin and the nucleoprotein of swine influenza virus. Veterinary Microbiology 118: 6775.
Wesley, RD, Tang, M and Lager, KM (2004). Protection of weaned pigs by vaccination with human adenovirus 5 recombinant viruses expressing the hemagglutinin and the nucleoprotein of H3N2 swine influenza virus. Vaccine 22: 34273434.
Wise, HM, Foeglein, A, Sun, JC, Dalton, RM, Patel, S, Howard, W, Anderson, EC, Barclay, WS and Digard, P (2009). A complicated message: identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA. Journal of Virology 83: 80218031.
Wolff, JA, Malone, RW, Williams, P, Chong, W, Acsadi, G, Jani, A and Felgner, PL (1990). Direct gene transfer into mouse muscle in vivo. Science 247: 14651468.
Yuan, Z, Zhang, S, Liu, Y, Zhang, F, Fooks, AR, Li, Q and Hu, R (2008). A recombinant pseudorabies virus expressing rabies virus glycoprotein: safety and immunogenicity in dogs. Vaccine 26: 13141321.
Zell, R, Scholtissek, C and Ludwig, S (2012). Genetics, evolution, and the zoonotic capacity of European swine influenza viruses. Current Topics in Microbiology and Immunology (advance access published Sep 26, 2012), doi:10.1007/82_2012_267.
Zhao, K, Shi, X, Zhao, Y, Wei, H, Sun, Q, Huang, T, Zhang, X and Wang, Y (2011). Preparation and immunological effectiveness of a swine influenza DNA vaccine encapsulated in chitosan nanoparticles. Vaccine 29: 85498556.
Zhou, NN, Senne, DA, Landgraf, JS, Swenson, SL, Erickson, G, Rossow, K, Liu, L, Yoon, KJ, Krauss, S and Webster, RG (1999). Genetic reassortment of avian, swine, and human influenza A viruses in American pigs. Journal of Virology 73: 88518856.
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Animal Health Research Reviews
  • ISSN: 1466-2523
  • EISSN: 1475-2654
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