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Growth promotion by oral administration of enkephalinase inhibitors (thiorphan and acetorphan) in rats and mice

Published online by Cambridge University Press:  02 September 2010

P. J. M. Rivière  and
L. Buéno
P. J. M. Rivière
Affiliation:
Department of Pharmacology, Institut National Recherche Agronomique, 180 chemin de Tournefeuille, 31300 Toulouse, France
L. Buéno
Affiliation:
Department of Pharmacology, Institut National Recherche Agronomique, 180 chemin de Tournefeuille, 31300 Toulouse, France
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Abstract

The effects of long-term oral administration of enkephalinase inhibitors (acetorphan and thiorphan) on food and water intake, live-weight gain and food conversion efficiency were investigated in growing rats and mice. In rats, daily drenching with acetorphan (an absorbable prodrug of thiorphan) at 1 mg/kg per day for 8 days did not alter food and water consumption but significantly increased live-weight gain (32·0 (s.d. 5·1) g for control rats v. 40·7 (s.d. 9·1) g for treated rats (P ≤ 0·05 U test) and improved food conversion efficiency (4·37 (s.d. 0·49) g food per g gain for control rats v. 3·70 (s.d. 0·67) g food per g gain for treated rats). In mice, lower doses (0·2 mg/kg per day) of thiorphan and acetorphan given in the drinking water similarly affected live-weight gain (7·7 (s.d. 0·9) g v. 6·0 (s.d. 1·6) g in 3-week-old mice receiving thiorphan and 2·6 (s.d. 0·4) g in 5-week-old mice receiving acetorphan) with a likely improvement in food conversion efficiency. These results suggest that oral administration of enkephalinase inhibitors may alter growth in rodents, probably by affecting the digestive process.

Type
Research Article
Information
Animal Production , Volume 46 , Issue 2 , April 1988 , pp. 291 - 295
Copyright
Copyright © British Society of Animal Science 1988

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