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Use of meloxicam, buprenorphine, and Maxilene® to assess a multimodal approach for piglet pain management, part 2: tail-docking

Published online by Cambridge University Press:  01 January 2023

AV Viscardi  and
PV Turner
AV Viscardi*
Affiliation:
Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada
PV Turner
Affiliation:
Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada Charles River Laboratories Inc, 251 Ballardvale St, Wilmington, MA 01887, USA
*
* Contact for correspondence: aviscardi@vet.k-state.edu
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Abstract

Piglets on commercial pig farms are often tail-docked to reduce the incidence of tail-biting. While this is a painful procedure, piglets are often not provided analgesia or anaesthesia for pain relief. The objectives of this study were to assess a multimodal approach to managing tail-docking pain in piglets, using 0.4 mg kg-1 meloxicam (MEL), 0.04 mg kg-1 buprenorphine (BUP), and Maxilene® (MAX), a topical anaesthetic. The effectiveness of each drug and drug combination was evaluated using behavioural indicators, vocalisation, and facial grimace analysis. This study also assessed whether male and female piglets responded differently to pain or pain treatments. Piglets were randomly assigned to one of six possible treatments: MEL, BUP, MEL + BUP, MEL + BUP + MAX, no treatment (tail-docked control), or sham (non-tail-docked control). Vocalisations were recorded at initial handling, injection, and tail-docking. Piglets administered MEL + BUP and BUP demonstrated significantly fewer pain behaviours than piglets in the MEL and no treatment group. MEL + BUP + MAX and BUP piglets displayed significantly lower facial grimace scores than piglets in the no treatment group. There were no significant differences in emitted vocalisations between the analgesia-treated piglets and the no treatment group and both injection and tail-docking elicited piglet vocalisations of similar frequency, power, and energy. There were no significant differences in behaviour, facial grimacing or emitted vocalisations between male and female piglets. All treatment groups with buprenorphine were able to alleviate tail-docking-associated pain, suggesting that opioid administration is highly effective for managing piglet pain.

Keywords

analgesiaanimal welfaremultimodalpain assessmentpiglettail-docking
Type
Articles
Information
Animal Welfare , Volume 28 , Issue 4 , November 2019 , pp. 499 - 510
Copyright
© 2019 Universities Federation for Animal Welfare

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References

Berger, N and Eeg, PH 2006 Veterinary Laser Surgery: A Practical Guide pp 101–108. Blackwell Publishing: Iowa, USA. https://doi.org/10.1002/9780470344491CrossRefGoogle Scholar
Costa, ED, Minero, M, Lebelt, D, Stucke, D, Canali, E and Leach, MC 2014 Development of the horse grimace scale (HGS) as a pain assessment tool in horses undergoing routine castration. PLoS One 9: e92281. https://doi.org/10.1371/journal.pone.0092281CrossRefGoogle Scholar
Craft, RM 2003 Sex differences in drug- and non-drug-induced analgesia. Life Sciences 72: 2675–2688. https://doi.org/10.1016/S0024-3205(03)00178-4CrossRefGoogle ScholarPubMed
Craft, RM, Mogil, JS and Aloisi, AM 2004 Sex differences in pain and analgesia: the role of gonadal hormones. European Journal of Pain 8: 397–411. https://doi.org/10.1016/j.ejpain.2004.01.003CrossRefGoogle ScholarPubMed
Di Giminiani, P, Edwards, SA, Malcolm, EM, Leach, MC, Herskin, MS and Sandercock, DA 2017 Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs. Scientific Reports 7: 4827. https://doi.org/10.1038/s41598-017-05404-yCrossRefGoogle Scholar
Eichenfield, LF, Funk, A, Fallon-Friedlander, S and Cunningham, BB 2002 A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children. Pediatrics 109: 1093–1099. https://doi.org/10.1542/peds.109.6.1093CrossRefGoogle ScholarPubMed
Fillingim, RB, King, CD, Ribeiro-Dasilva, MC, Rahim-Williams, B and Riley, JL 2009 Sex, gender, and pain: a review of recent clinical and experimental findings. The Journal of Pain 10:447–485. https://doi.org/10.1016/j.jpain.2008.12.001CrossRefGoogle Scholar
Flecknell, P 2015 Laboratory Animal Anaesthesia, 4th Edition pp 174. Elsevier: Amsterdam, The NetherlandsGoogle Scholar
Goffaux, P, Michaud, K, Gaudreau, J, Chalaye, P, Rainville, P and Marchand, S 2011 Sex differences in perceived pain are affected by an anxious brain. Pain 152: 2065–2073. https://doi.org/10.1016/j.pain.2011.05.002CrossRefGoogle ScholarPubMed
Greenspan, JD, Craft, RM, LeResche, L, Arendt-Nielsen, L, Berkley, KJ, Fillingim, RB, Gold, MS, Holdcroft, A, Lautenbacher, S, Mayer, EA, Mogil, JS, Murphy, AZ and Traub, RJ 2007 Studying sex and gender differences in pain and analgesia: a consensus report. Pain 132: S26–S45. https://doi.org/10.1016/j.pain.2007.10.014CrossRefGoogle ScholarPubMed
Hay, M, Vulin, A, Genin, S, Sales, P and Prunier, A 2003 Assessment of pain induced by castration in piglets: behaviour and physiological responses over the subsequent 5 days. Applied Animal Behaviour Science 82: 201–218. https://doi.org/10.1016/S0168-1591(03)00059-5CrossRefGoogle Scholar
Herskin, MS, Di Giminiani, P and Thodberg, K 2016 Effects of administration of a local anaesthetic and/or an NSAID and of docking length on the behaviour of piglets during 5h after tail docking. Research in Veterinary Science 108: 60–67. https://doi.org/10.1016/j.rvsc.2016.08.001CrossRefGoogle ScholarPubMed
Hewson, CJ, Dohoo, IR and Lemke, KA 2006 Perioperative use of analgesics in dogs and cats by Canadian veterinarians in 2001. The Canadian Veterinary Journal 47: 352–359Google ScholarPubMed
Hunter, EJ, Jones, TA, Guise, HJ, Penny, RHC and Hoste, S 2001 The relationship between tail biting in pigs, docking proce-dure and other management practices. The Veterinary Journal 161:72–79. https://doi.org/10.1053/tvjl.2000.0520CrossRefGoogle Scholar
Janczak, AM, Ranheim, B, Fosse, TK, Hild, S, Nordgreen, J, Moe, RO and Zanella, AJ 2012 Factors affecting mechanical (nociceptive) thresholds in piglets. Veterinary Anaesthesia and Analgesia 39: 628–635. https://doi.org/10.1111/j.1467-2995.2012.00737.xCrossRefGoogle ScholarPubMed
Langford, DJ, Bailey, AL, Chanda, ML, Clarke, SE, Drummond, TE, Echols, S, Glick, S, Ingrao, J, Klassen-Ross, T, LaCroix-Fralish, ML, Matsumiya, L, Sorge, RE, Sotocinal, SG, Tabaka, JM, Wong, D, van den Maagdenberg, AMJM, Ferrari, MD, Craig, KD and Mogil, JS 2010 Coding of facial expressions of pain in the laboratory mouse. Nature Methods 7:447–449. https://doi.org/10.1038/nmeth.1455CrossRefGoogle ScholarPubMed
Marchant-Forde, JN, Lay, DC Jr, McMunn, KA, Cheng, HW, Pajor, EA and Marchant-Forde, RM 2009 Postnatal piglet hus-bandry practices and well-being: the effects of alternative techniques delivered separately. Journal of Animal Science 87: 1479–1492. https://doi.org/10.2527/jas.2008-1080CrossRefGoogle Scholar
Marx, G, Horn, T, Thielebein, J, Knubel, B and von Borell, E 2003 Analysis of pain-related vocalizations in young pigs. Journal of Sound and Vibration 266: 687–698. https://doi.org/10.1016/S0022-460X(03)00594-7CrossRefGoogle Scholar
Meijer, E, van Nes, A, Back, W and van der Staay, FJ 2015 Clinical effects of buprenorphine on open field behaviour and gait symmetry in healthy and lame weaned piglets. The Veterinary Journal 206: 298–303. https://doi.org/10.1016/j.tvjl.2015.10.016CrossRefGoogle ScholarPubMed
Mogil, JS, Chesler, EJ, Wilson, SG, Juraska, JM and Sternberg, WF 2000 Sex differences in thermal nociception and morphine antinociception in rodents depend on genotype. Neuroscience & Biobehavioural Reviews 24: 375–389. https://doi.org/10.1016/S0149-7634(00)00015-4CrossRefGoogle ScholarPubMed
National Farm Animal Care Council 2014 Code of practice for the care and handling of pigs. http://www.nfacc.ca/pdfs/codes/pig_code_of_practice.pdfGoogle Scholar
Noonan, GJ, Rand, JS, Priest, J, Ainscow, J and Blackshaw, JK 1994 Behavioural observations of piglets undergoing tail docking, teeth clipping and ear notching. Applied Animal Behaviour Science 39: 203–213. https://doi.org/10.1016/0168-1591(94)90156-2CrossRefGoogle Scholar
Rodriguez, NA, Cooper, DM and Risdahl, JM 2001 Antinociceptive activity of and clinical experience with buprenor-phine in swine. Journal of the American Association for Laboratory Animal Science 40: 17–20Google Scholar
Rutherford, KMD, Robson, SK, Donald, RD, Jarvis, S, Sandercock, DA, Scott, EM, Nolan, AM and Lawrence, AB 2009 Pre-natal stress amplifies the immediate behavioural responses to acute pain in piglets. Biology Letters 5: 452–454. https://doi.org/10.1098/rsbl.2009.0175CrossRefGoogle ScholarPubMed
Sarajari, S and Oblinger, MM 2010 Estrogen effects on pain sensitivity and neuropeptide expression in rat sensory neurons. Experimental Neurology 224: 163–169. https://doi.org/10.1016/j.expneurol.2010.03.006CrossRefGoogle ScholarPubMed
Sorge, RE, Martin, LJ, Isbester, KA, Sotocinal, SG, Rosen, S, Tuttle, AH, Wieskopf, JS, Acland, EL, Dokova, A, Kadoura, B, Leger, P, Mapplebeck, JCS, McPhail, M, Delaney, A, Wigerblad, G, Schumann, AP, Quinn, T, Frasnelli, J, Svensson, CI, Sternberg, WF and Mogil, JS 2014 Olfactory exposure to males, including men, causes stress and related anal-gesia in rodents. Nature Methods 11: 629–632. https://doi.org/10.1038/nmeth.2935CrossRefGoogle Scholar
Suresh, KP and Chandrashekara, S 2012 Sample size estimation and power analysis for clinical research studies. Journal of Human Reproductive Sciences 5: 7–13. https://doi.org/10.4103/0974-1208.97779CrossRefGoogle ScholarPubMed
Sutherland, MA 2015 Welfare implications of invasive piglet husbandry procedures, methods of alleviation and alternatives: a review. The New Zealand Veterinary Journal 63: 52–57. https://doi.org/10.1080/00480169.2014.961990CrossRefGoogle ScholarPubMed
Sutherland, MA, Bryer, PJ, Krebs, N and McGlone, JJ 2008 Tail docking in pigs: acute physiological and behavioural respons-es. Animal 2: 292–297. https://doi.org/10.1017/S1751731107001450CrossRefGoogle Scholar
Sutherland, MA, Bryer, PJ, Krebs, N and McGlone, JJ 2009 The effect of method of tail docking on tail-biting behaviour and welfare of pigs. Animal Welfare 18: 561–570Google Scholar
Sutherland, MA, Davis, BL and McGlone, JJ 2011 The effect of local or general anesthesia on the physiology and behaviour of tail docked pigs. Animal 5: 1237–1246. https://doi.org/10.1017/S175173111100019XCrossRefGoogle ScholarPubMed
Telkänranta, H, Swan, K, Hirvonen, H and Valros, A 2014 Chewable materials before weaning reduce tail biting in growing pigs. Applied Animal Behaviour Science 157: 14–22. https://doi.org/10.1016/j.applanim.2014.01.004CrossRefGoogle Scholar
Torrey, S, Devillers, N, Lessard, M, Farmer, C and Widowski, T 2009 Effect of age on the behavioural and physiological respons-es of piglets to tail docking and ear notching. Journal of Animal Science 87: 1778–1786. https://doi.org/10.2527/jas.2008-1354CrossRefGoogle ScholarPubMed
Traub, RJ and Ji, Y 2013 Sex differences and hormonal modulation of deep tissue pain. Frontiers in Neuroendocrinology 34: 350–366. https://doi.org/10.1016/j.yfrne.2013.07.002CrossRefGoogle ScholarPubMed
US Department of Agriculture 2018 Opioid misuse in rural America. https://www.usda.gov/topics/opioidsGoogle Scholar
US Food & Drug Administration 2014 BupreLab- for the con-trol of post procedural pain in rats. https://www.fda.gov/down-loads/AnimalVeterinary/DevelopmentApprovalProcess/MinorUse MinorSpecies/UCM373292.pdfGoogle Scholar
Viscardi, AV, Hunniford, M, Lawlis, P, Leach, M and Turner, PV 2017 Development of a piglet grimace scale to evaluate piglet pain using facial expressions following castration and tail docking: a pilot study. Frontiers in Veterinary Science 4: 51. https://doi.org/10.3389/fvets.2017.00051CrossRefGoogle ScholarPubMed
Viscardi, AV and Turner, PV 2018a Efficacy of buprenor-phine for management of surgical castration pain in piglets. BMC Veterinary Research 14: 318. https://doi.org/10.1186/s12917-018-1643-5CrossRefGoogle Scholar
Viscardi, AV and Turner, PV 2018b Use of meloxicam or keto-profen for piglet pain control following surgical castration. Frontiers in Veterinary Science 5: 299. https://doi.org/10.3389/fvets.2018.00299CrossRefGoogle ScholarPubMed