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Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16

Published online by Cambridge University Press:  01 July 1998

J. A. CAVANAUGH ,
D. F. CALLEN ,
S. R. WILSON ,
P. M. STANFORD ,
M. E. SRAML ,
M. GORSKA ,
J. CRAWFORD ,
S. A. WHITMORE ,
C. SHLEGEL  and
S. FOOTE
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J. A. CAVANAUGH
Affiliation:
Gastroenterology Unit, The Canberra Hospital, Gilmore Crescent, Garran, ACT 2606, Australia
D. F. CALLEN
Affiliation:
Department of Cytogenetics and Molecular Genetics, Women's and Children's Hospital, North Adelaide SA 5006, Australia
S. R. WILSON
Affiliation:
Centre for Mathematics and its Applications, Australian National University, Canberra, ACT 0200, Australia
P. M. STANFORD
Affiliation:
Gastroenterology Unit, The Canberra Hospital, Gilmore Crescent, Garran, ACT 2606, Australia
M. E. SRAML
Affiliation:
Gastroenterology Unit, The Canberra Hospital, Gilmore Crescent, Garran, ACT 2606, Australia
M. GORSKA
Affiliation:
Gastroenterology Unit, The Canberra Hospital, Gilmore Crescent, Garran, ACT 2606, Australia
J. CRAWFORD
Affiliation:
Department of Cytogenetics and Molecular Genetics, Women's and Children's Hospital, North Adelaide SA 5006, Australia
S. A. WHITMORE
Affiliation:
Department of Cytogenetics and Molecular Genetics, Women's and Children's Hospital, North Adelaide SA 5006, Australia
C. SHLEGEL
Affiliation:
Gastroenterology Unit, The Canberra Hospital, Gilmore Crescent, Garran, ACT 2606, Australia
S. FOOTE
Affiliation:
Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3050, Australia
M. KOHONEN-CORISH
Affiliation:
Division of Molecular Medicine, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
P. PAVLI
Affiliation:
Gastroenterology Unit, The Canberra Hospital, Gilmore Crescent, Garran, ACT 2606, Australia
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Abstract

A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al. (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis (Ohmen et al. 1996; Parkes et al. 1996). We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.

Type
Research Article
Information
Annals of Human Genetics , Volume 62 , Issue 4 , July 1998 , pp. 291 - 298
Copyright
© University College London 1998

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